How do I know if my antidepressant works? When you start taking an antidepressant, you should begin to function better in your daily life before you start feeling better, says Dr. Michael McGee. In other words, you should begin sleeping better, eating better, and having more energy.
If your depression symptoms get worse as soon as you start taking an antidepressant, or they get better and then very suddenly get worse, it's a sign that the depression medication isn't working properly, and you should see your health care professional right away.
When first starting antidepressants, some people have mild stomach upset, headache or fatigue, but these side effects often diminish in the first few weeks as the body adjusts. Some people gain weight, though many stay “weight neutral,” and some even lose weight, Dr. Cox says.
You may feel some depression symptoms improve within the first couple weeks, but it can often take 4 to 8 weeks to feel the full effects of your medication. If you've taken your antidepressant for at least 4 weeks with no improvement, let your healthcare provider know.
Fact: When taken correctly, antidepressants will not change your personality. They will help you feel like yourself again and return to your previous level of functioning.
Taking antidepressants may help to lift your mood. This can help you feel more able to do things that don't feel possible while you're depressed. This may include using other types of support for your mental health.
When first starting antidepressants, you may suddenly find that you don't feel like yourself anymore. Though your depression symptoms may have improved, the overwhelming waves of gloom can sometimes be replaced by an emotional inertness in which are neither able to cry nor share a real belly laugh.
What are the most common antidepressants? Sertraline hydrochloride, used for multiple mental health and mood disorders, is the most prescribed antidepressant on the list with more than 18 million prescriptions in 2021.
Depression relapses can happen at any time, even if you're already receiving treatment or are on medication for depression. It's like any other condition — if you have it once, you may be predisposed to it and are more likely to experience it again.
Antidepressants can cause unpleasant side effects. Signs and symptoms such as nausea, weight gain or sleep problems can be common initially. For many people, these improve within weeks of starting an antidepressant. In some cases, however, antidepressants cause side effects that don't go away.
Common side effects of selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs) can include: feeling agitated, shaky or anxious. feeling and being sick.
Take your time.
You may be tempted to stop taking antidepressants as soon as your symptoms ease, but depression can return if you quit too soon. Clinicians generally recommend staying on the medication for six to nine months before considering going off it.
New stressors. A new stressful situation at home or work can result in a mood response for which the antidepressant can't compensate. Other medications. Interactions between antidepressants and medications for other health conditions can affect how well an antidepressant works.
It's usually recommended that a course of antidepressants continues for at least 6 months after you feel better, to prevent your condition recurring when you stop. Some people with recurrent illness are advised to carry on taking medicine indefinitely.
However, in some people, a particular antidepressant may simply stop working over time. Doctors don't fully understand what causes the so-called "poop-out" effect or antidepressant tolerance — known as tachyphylaxis — or why it occurs in some people and not in others.
During these episodes, symptoms occur most of the day, nearly every day and may include: Feelings of sadness, tearfulness, emptiness or hopelessness. Angry outbursts, irritability or frustration, even over small matters. Loss of interest or pleasure in most or all normal activities, such as sex, hobbies or sports.
Depression episodes can be triggered by factors such as stressful events, loss, illness, lifestyle habits, and substance use.
Antidepressants are usually taken daily. The goal in the first few weeks and months is to relieve the symptoms and, where possible, make the depression go away. Once that has been achieved, the treatment is continued for at least four to nine months.
Exercise. Research suggests that regular exercise may be a more effective treatment for mild depression than antidepressants. Exercise helps boost levels of chemicals called serotonin and dopamine in the brain, which can lift your mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They can ease symptoms of moderate to severe depression, are relatively safe and typically cause fewer side effects than other types of antidepressants do.
On antidepressant medication, it is possible that you might experience a sense of feeling numb and less like yourself. Though the symptoms of depression have decreased, there may be a sense that other emotional responses – laughing or crying, for example – are more difficult to experience.
People experiencing this side effect often describe themselves as feeling “flat” or “detached,” or having “dull” emotions. Other terms for emotional blunting include emotional indifference, diminished emotional responsiveness, and reduced emotional sensitivity.
Nearly half of patients on all types of monoaminergic antidepressants report emotional blunting,6 and it is associated with serotonin reuptake inhibitor (SSRI) therapy as follows: among 161 patients, 46% reported a narrowed range of affect, 21% reported an inability to cry, and 19% reported apathy.
Although this is beneficial for someone who's depressed, for someone who does not have depression, taking antidepressant medication can cause serotonin to build up in the body, resulting in serotonin syndrome. When serotonin levels are too high, the person may experience symptoms like: Agitation or restlessness.