Long-acting benzodiazepines include diazepam (with the fastest onset of action), clorazepate (also fast onset), chlordiazepoxide (intermediate onset), f1urazepam (slow onset), and prazepam (slowest onset).
Midazolam is one of the most lipophilic benzodiazepines, due to which there is a quick crossing of the blood-brain barrier and rapid onset of clinical effects.
Shorter-acting benzodiazepines used to manage insomnia include estazolam (ProSom®), flurazepam (Dalmane®), temazepam (Restoril®), and triazolam (Halcion®). Midazolam (Versed®), a short-acting benzodiazepine, is utilized for sedation, anxiety, and amnesia in critical care settings and prior to anesthesia.
Diazepam and midazolam are the most lipophilic, and have the fastest onset of action.
Temazepam. Temazepam 10mg is approximately equivalent to diazepam 5mg. Temazepam is used short-term for the treatment of insomnia, and as pre-medication before minor surgical and investigative procedures. The dose is taken at bedtime (for insomnia), or half to one hour before the procedure (as pre-medication).
What Is the Strongest Benzodiazepine for Sleep? Nitrazepam, loprazolam, and lormetazepam are the strongest and more effective benzos that can work as sleeping pills to treat insomnia. Some drugs prescribed for anxiety can help patients sleep better if they are mandated to take them at night.
Temazepam. Temazepam 10mg is approximately equivalent to diazepam 5mg. Temazepam is used short-term for the treatment of insomnia, and as pre-medication before minor surgical and investigative procedures.
Short-acting (eg, triazolam) and intermediate-acting (eg, estazolam, temazepam) benzodiazepine receptor agonists are useful for sleep-onset insomnia. These agents have been the hypnotics of choice for many years because of their relative safety compared with the barbiturates, as well as their low cost.
Diazepam is better absorbed after oral than after i.m. administrations but this does not apply to lorazepam. The clinical effect and amnesia begin more rapidly with diazepam, but last longer following lorazepam. Lorazepam is more effective than diazepam in blocking the emergence sequelae from ketamine.
Midazolam is the fastest acting of its class because of its lipophilic abilities, and it is superior to lorazepam and diazepam in its amnestic effects, making it the ideal benzodiazepine for use in short ED procedures.
These drugs are less likely to keep working if you take them continuously for more than a few weeks. This is because your brain can get used to their effects. It can also mean that when you stop taking the drugs, your brain becomes very sensitive to natural brain chemicals.
The sedative effect of clonazepam on Müller's labyrinth is more potent compared to diazepam. Unlike diazepam metabolites, that show high activity in experiments, the products of clonazepam biotransformation are less potent.
Pyrazolam was reported to be the most anxiolytic DBZD, flubromazolam the most hypnotic, etizolam the most euphoric and flubromazolam and clonazolam as the most amnesic DBZDs.
How long does diazepam take to start working? Diazepam starts to work very quickly in your body, and you should get calming effects within two hours of taking it.
Suvorexant is the first orexin receptor antagonist to be marketed in Australia. The drug is taken within 30 minutes of bedtime. This should be at least seven hours before the patient plans to get up again. The maximum drug concentration is reached in two hours.
Zolpidem 10 mg provided greater subjective hypnotic efficacy than temazepam 15 mg in this model of transient insomnia, with reduced polysomnographic awakenings and WASO.
Benzodiazepines most commonly used to treat anxiety disorders are clonazepam (Rivotril)*, alprazolam (Xanax) and lorazepam (Ativan). Also used are bromazepam (Lectopam), oxazepam (Serax), chlordiazepoxide (once marketed as Librium), clorazepate (Tranxene) and diazepam (Valium).
For example, if you have general anxiety, a long-lasting benzo, like diazepam or clonazepam, might be the best first choice.
Benzodiazepines: Doctors prescribe benzodiazepines to treat insomnia or anxiety that is disabling, severe, and causing extreme distress. Diazepam (Valium), alprazolam (Xanax), and triazolam (Halcion) are examples of benzodiazepines.
Taking more than your prescribed dose of temazepam can be dangerous. It can make you very sleepy, and affect your balance and speech. You could have difficulty breathing, especially if you have taken other medicines or alcohol at the same time.
Temazepam is used to treat insomnia (trouble with sleeping). This medicine is for short-term (usually 7 to 10 days) use only. Temazepam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.
sleep problems (related to anxiety) – 5mg to 15mg, taken once a day at bedtime. muscle spasms in adults – 2mg to 15 mg a day. This can be taken as 1mg twice a day and can go up to 5mg taken 3 times a day.