Fluid retention is one of prednisone's most famous side effects. “'Moon face' is common, which is swelling in the face that can occur after you've been on steroids for a long time,” Dr. Ford notes. “You can also get swelling in the legs and midsection.”
Corticosteroids — like prednisone — can have serious long-term side effects. This is especially true when someone takes them for a long time or at a higher dose. Examples of corticosteroids side effects include weight gain, osteoporosis, eye problems, and increased infection risk.
Prednisone has a tendency to raise the level of glucose, or sugar, in the blood, which can cause increased body fat or diabetes in some people. It is important to avoid "simple" carbohydrates and concentrated sweets, such as cakes, pies, cookies, jams, honey, chips, breads, candy and other highly processed foods.
The primary adverse effects of prednisone include hyperglycemia, insomnia, increased appetite, hypertension, osteoporosis, edema, adrenal suppression, cataracts, and delayed wound healing.
This depends on your health problem or condition. You may only need a short course of prednisolone for up to 1 week. You may need to take it for longer, even for many years or the rest of your life.
A gradual reduction in prednisone dosage gives your adrenal glands time to resume their usual function. The amount of time it takes to taper off prednisone depends on the disease being treated, the dose and duration of use, and other medical considerations. A full recovery can take a week to several months.
Caffeine: Caffeine can add to the unwanted stimulant effects of prednisone. Combining caffeine with steroids can keep you awake at night or make you feel jittery and anxious.
Risks of Prednisone
More serious side effects, such as an increased risk of infections, psychological effects, weakening of bones, and bone fractures are associated with longer-term use.
Fluid retention can cause weight gain but as steroids are reduced, fluids will usually reduce as well, along with some of the weight gain. Drinking plenty of water and exercising can help with fluid retention.
Specific medications in this group include (in no particular order) Flovent, Pulmicort, QVAR, Asmanex, and many others, both brand-name and generic. These are medicines that are similar to prednisone, but the dose is much lower than prednisone taken by mouth, and the side effects are dramatically reduced.
If symptoms such as abdominal pain, fever or unusual digestive problems (diarrhea, constipation) occur during corticosteroid therapy, notify your physician.
Long-term use of prednisone may lead to bone loss and osteoporosis. It can cause changes in the distribution of body fat which together with fluid retention and weight gain may give your face a moon-like appearance. Stretch marks, skin thinning, and excessive facial hair growth are also not uncommon.
A 5-day course of prednisone can cause short-term side effects, including changes in mood, appetite, sleep, and energy. The severity of the side effects depends on the dose of prednisone. Low doses are less likely to cause adverse effects than high doses of prednisone.
Still, dexamethasone is more potent (stronger) than prednisone. If you're in a situation where you need a more potent steroid, dexamethasone will likely be the preferred option between the two. It also works longer in your body than prednisone does.
Acute prednisone side effects
These can occur within days to weeks of starting the medication and may be cause for adjusting or even stopping the medication (with guidance from your doctor, of course).
It's best to avoid drinking alcohol while taking prednisone or other corticosteroids (“steroids”). Alcohol can make some steroid side effects worse. It can also sometimes worsen the underlying condition being treated. On their own, steroids, like prednisone, and alcohol can suppress your immune system.
Also, increase your intake of low-fat foods that have high calcium levels. Some of these include corn, sardines, almonds, broccoli, milk, yogurt, cheese, tofu, cooked soybeans, boiled white beans, and salmon.
A person taking prednisone may want to avoid alcohol until they finish the treatment. Alcohol can worsen some side effects of prednisone, such as immune system suppression, bone weakening, and weight gain. It is best to speak with a doctor to avoid serious complications.
Steroids won't cure your condition, but they're very good at reducing inflammation and will ease symptoms such as swelling, pain and stiffness. Usually inflammation is the body's natural reaction to infection or bacteria.
Official answer
It takes approximately 16.5 to 22 hours for Prednisone to be out of your system. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half.
Official answer. Prednisone usually works very quickly, within a few hours to days of taking the first dose depending on the condition you are treating. If the prescribed dose of prednisone is effective at reducing your inflammation, then you may notice an effect within hours.