Blood-thinning medications: There have been reports that CoQ10 may make medications such as warfarin (Coumadin) or clopidigrel (Plavix) less effective at thinning the blood. If you take blood thinners, ask your provider before taking CoQ10.
No serious side effects of CoQ10 have been reported. Mild side effects such as insomnia or digestive upsets may occur. CoQ10 may interact with the anticoagulant (blood thinner) warfarin and the diabetes drug insulin, and it may not be compatible with some types of cancer treatment.
While it's generally considered to be safe for healthy adults, CoQ10 can be potentially harmful to people with certain conditions or those taking certain medications. The typical dose ranges from 100 mg of CoQ10 or 25 mg of ubiquinol daily for generally healthy people not taking any medications.
Answer: Yes. Although CoQ10 is generally well-tolerated, it can cause gastrointestinal symptoms such as nausea and diarrhea in a small percentage of people.
Many cardiologists place their patients on CoQ10 to help cardiac function as well as to reduce the bad side effects of statin cholesterol drugs. The supplement also may help decrease the pain of rheumatoid arthritis by decreasing the bad inflammatory chemicals that lead to cartilage breakdown.
Generally safe. CoQ10 supplements might be beneficial for treating conditions such as congestive heart failure and preventing migraines. CoQ10 is considered safe, with few side effects. However, be sure to take this supplement under your doctor's supervision.
Once you start taking CoQ10, you'll want to keep taking it until you become pregnant, at which time you may reduce the dosage or discontinue use.
Researchers report that CoQ10 may have significant benefits for people with cardiovascular disease (CVD), from reducing risk for repeat heart attacks and improving outcomes in patients with heart failure to lowering blood pressure and helping combat side effects of cholesterol-lowering statins.
While most people tolerate coenzyme Q10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure.
There are many potential benefits to CoQ10 supplementation, including male fertility, female fertility, cardiovascular health, and some anti-aging benefits. CoQ10 is fat-soluble and should be taken with a meal. This can be taken in the morning or at night, as long as it's accompanied by fats or oils.
CoQ10 supplements can be taken without a duration limit. Clinical studies of high doses have lasted several years without issue. At the very least, you should take CoQ10 for a few weeks. It's not an acute kind of supplement that you take on an as-needed basis.
Scientists have found that CoQ10 supplements are potentially beneficial to people living with heart disease. In a long-term study, people living with moderate to severe heart failure who took daily CoQ10 supplements had a reduced risk — specifically 42% — of having their first major adverse cardiovascular event (MACE).
CoQ10 is a potent antioxidant and free-radical scavenger, with mounting evidence demonstrating that it could protect the kidney from ischemia–reperfusion (I/R) injury.
Preclinical and clinical studies have shown that CoQ10 has anti-inflammatory and antioxidant effects, and effects on mitochondrial dysfunction, which have been linked to the inflammatory response.
Furthermore, CoQ10 supplementation confers health benefits in elderly people by preventing chronic oxidative stress associated with cardiovascular and neurodegenerative diseases (Gonzalez-Guardia et al., 2015).
The data on CoQ10 and blood pressure is mixed, and most data suggests CoQ10 does not have an impact on heart rate [1,15]. Fish oil, however, has shown promising results in many research studies for lowering blood pressure and was shown to decrease heart rate in a few trials [10,16].
CoQ10 has been shown to help decrease blood pressure, help with migraine relief, lower blood sugar, improve Parkinson's disease, memory, and help reduce fatigue in fibromyalgia. Those are just a few of the non cardiac benefits of this substance.
What are the symptoms of CoQ10 deficiency? Whilst everyone is different, people who have a deficiency in CoQ10 levels often experience physical fatigue and muscle weakness, even while undertaking relatively non-strenuous physical activities such as walking.
Interactions between your drugs
No interactions were found between CoQ10 and magnesium oxide.
Glucosamine and chondroitin are two of the most commonly used supplements for arthritis. They're components of cartilage—the substance that cushions the joints. Research on these supplements has been mixed, in part because studies have used varying designs and supplement types.
Based on the results of this meta-analysis, we conclude that CoQ10 is an effective and safe supplement for reducing fatigue symptoms.