People with vitamin B12 deficiency can have neurological symptoms and/or damage without anemia (lack of red blood cells). General physical symptoms of vitamin B12 deficiency can include: Feeling very tired or weak. Experiencing nausea, vomiting or diarrhea.
Untreated, vitamin B-12 deficiency can lead to neurological problems, such as persistent tingling in the hands and feet or problems with balance. It can lead to mental confusion and forgetfulness because vitamin B-12 is necessary for healthy brain function.
Diet. Some people can develop a vitamin B12 deficiency as a result of not getting enough vitamin B12 from their diet. A diet that includes meat, fish and dairy products usually provides enough vitamin B12, but people who do not regularly eat these foods can become deficient.
Once you begin treating your vitamin B12 deficiency, it can take up to six to 12 months to fully recover. It is also common to not experience any improvement during the first few months of treatment. If you can, it's a good idea to address what's causing the deficiency.
Vitamin B12 deficiency is common, but extremely low levels can be dangerous and cause symptoms that interfere with your life. When untreated over time, the physical and psychological symptoms of this deficiency may be debilitating and make you feel like you're dying.
The psychiatric manifestations include cognitive changes (like memory decline), depression, delusions, hallucinations, and dementia (Engelborghs et al., 2004). The mechanisms behind are instable production of neurotransmitters and elevated homocysteine and methylmalonic acid (MMA) level in B12 deficient people.
Since B12 shots are injected intramuscularly bypassing the digestive process, they start to work immediately. Typically, our patients experience positive effects between 24-72 hours after the treatment.
Bananas also contain fibre and potassium. It helps manage blood pressure, reduce stress, and relieve constipation and ulcer problems. The fruit also helps regulate body temperature. Another fruit that is rich in vitamin B12 is blueberries.
[1] People who regularly take medications that suppress stomach acid for conditions like gastroesophageal reflux disease (GERD) or peptic ulcer disease—such as proton-pump inhibitors, H2 blockers, or other antacids—may have difficulty absorbing vitamin B12 from food.
Vegans who consume no animal products and vegetarians who consume some animal products (e.g., dairy products, eggs, or both) but not meat have a higher risk of developing vitamin B12 deficiency because natural food sources of vitamin B12 are limited to animal foods [3,55].
Most healthy people who have a well-balanced diet do not need to worry much about vitamin B12 deficiency. However, for those at risk (such as those with celiac disease), measures of blood vitamin B12 levels and, in some cases, preventive therapy with vitamin B12 may be recommended.
In addition, vitamin B12 is involved in the synthesis of important messenger substances such as neurotransmitters and hormones that control our brain function, thus our perception, mood and state of mind.
These neurologic symptoms are due to myelin degeneration and loss of nerve fibers in the dorsal and lateral columns of the spinal cord and cerebral cortex (subacute combined degeneration). Neurologic symptoms and findings may be present in the absence of anemia.
Vitamin B12 deficiency is linked to impaired cognition and memory along with a sensation of tingling and numbness, an outcome of poor myelination. Elevated methylmalonic acid and serum homocysteine levels are markers of Vitamin B12 deficiency.
A deficiency of vitamin B12 disrupts this reaction, which leads to reduced formation of S- adenosyl methionine. This impairs methylation of myelin basic protein and lipids and leads to damage to the myelin sheath.