Sjogren's syndrome is an autoimmune disease that can mimic some of the symptoms of MS such as fatigue and joint pain.
These include fibromyalgia and vitamin B12 deficiency, muscular dystrophy (MD), amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), migraine, hypo-thyroidism, hypertension, Beçhets, Arnold-Chiari deformity, and mitochondrial disorders, although your neurologist can usually rule them out quite easily.
Some of the most common mimics include migraine and chronic cerebrovascular disease, according to Dr Schiess. Vasculitic autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's syndrome can also result in white matter abnormalities on MRI.
Misdiagnosing MS can have harmful effects. A person may be started on an unnecessary treatment course with possibly detrimental side effects. That's why it's so important to work with your healthcare team to accurately diagnose MS and rule out every other possible reason for your symptoms.
False Results
MRI leads to false negatives—i.e., results that say MS is not present when it really is—in about 5% of MS cases. Other times, age-related damage or other conditions (migraine, brain trauma) look like MS lesions. This produces false positives, or results that indicate MS when it's not there.
Misinterpretation of abnormal MRI findings is a frequent contributor to misdiagnosis of MS. One study found that only 11% of patients who were referred to a MS subspecialty center based primarily on an abnormal MRI were subsequently diagnosed with MS.
The diagnosis of MS cannot be made solely on the basis of MRI because there are other diseases that cause lesions in the CNS that look like those caused by MS. And even people without any disease — particularly the elderly — can have spots on the brain that are similar to those seen in MS.
Answer & Explanation. The statement that is NOT true about multiple sclerosis (MS) is: b. MS results in destruction of the myelin sheaths of axons primarily in the peripheral nervous system.
Study of multiple sclerosis patients shows 18 percent misdiagnosed [Press Release].
The danger of misdiagnosis
MRI is used to look for the presence of lesions in particular compartments of the brain and spinal cord. Even with all these diagnostic criteria, many neurological conditions can masquerade as MS, and vice versa.
MRI is considered the best test to help diagnose MS. However, 5% of people with MS do not have abnormalities detected on MRI; thus, a "negative" scan does not completely rule out MS. In addition, some common changes of aging may look like MS on a MRI.
An MRI scanner uses a strong magnetic field to create a detailed image of inside your brain and spinal cord. It's very accurate and can pinpoint the exact location and size of any inflammation, damage or scarring (lesions). MRI scans confirm a diagnosis in over 90 per cent of people with MS.
There is a new blood test that may monitor multiple sclerosis disease activity better in clinically stable patients. The test is called sNfL (serum neurofilament). It measures the breakdown of a certain part of neurons, which occurs when multiple sclerosis is attacking the nervous system.
But despite some similarities, “for the most part, there is no mistaking symptoms of MS with fibromyalgia,” says Philip Cohen, MD, a rheumatologist, professor of medicine and professor of microbiology and immunology at the Lewis Katz School of Medicine at Temple University in Philadelphia.
Other causes
Other types of demyelinating disease and their causes include: Optic neuritis — inflammation of the optic nerve in one or both eyes. Neuromyelitis optica spectrum disorder (NMOSD) — inflammation and demyelination of the central nervous system, especially of the optic nerve and spinal cord.
Can thyroid issues mimic MS? Hyperthyroidism and hypothyroidism both share symptoms with MS, such as fatigue and muscle pains. However, doctors can distinguish the conditions with diagnostic tests.
Brain MRI is often used to help diagnose multiple sclerosis.
Your doctor will refer you to a neurologist. They will examine you to check how different parts of your nervous system are working. A combination of tests is used to diagnose MS. The best test is an MRI of your brain and spinal cord to detect areas of damage.
Those symptoms include loss of vision in an eye, loss of power in an arm or leg or a rising sense of numbness in the legs. Other common symptoms associated with MS include spasms, fatigue, depression, incontinence issues, sexual dysfunction, and walking difficulties.
Because sensory symptoms may occur in the absence of clinical signs the neurological examination may be normal or near normal even when seen during relapse.
MRI plays a vital role in how we diagnose and monitor MS. In fact, over 90% of people have their MS diagnosis confirmed by MRI.
The 'MS hug' is an MS symptom where you feel pain or tightness around the chest or stomach area. It's not dangerous, but it can be frightening, especially if you haven't come across it before.
Neurological examination
Your neurologist will look for abnormalities, changes or weakness in your vision, eye movements, hand or leg strength, balance and co-ordination, speech and reflexes. These may show whether your nerves are damaged in a way that might suggest MS.
Nail problems are common, and they are not usually serious. If a person has multiple sclerosis (MS), nail problems can cause pain or discomfort. While nail issues are not directly related to the disease, determining the cause may help prevent a person with MS from experiencing further discomfort.