The only thing capable of destroying him in the end was his own clone.
Comic Noir is actually revealed to be a Homelander clone, created by Vought as a backup plan in case their star supe were to go rogue. The silent killer eventually murders Homelander, and he is able to do so because he possesses the same lethal abilities as him.
Homelander's Real Weakness Is That He Craves Love & Adoration. Homelander is a vile and twisted character who comes alive in the public eye. Deep down, he's a true villain, but, whenever cameras are filming and people are watching, he does his best impression of a bright and hopeful hero.
The grand finale of The Boys comic book series confirms that there is only one hero who is actually stronger than Homelander, and that's his (even more) evil clone, Black Noir. Created to be an upgraded version of Homelander, Black Noir proves his superiority in the final battle between these two deranged powerhouses.
Homelander is seldom interested in the feelings of others, and this pattern is consistent with people who have NPD. It isn't that he doesn't detect hurt feelings, he simply does not see the value of attending to others unless it benefits him or his agenda.
In theory, Soldier Boy should be able to kill Homelander, assuming his power affects Homelander the same way it affected Kimiko. But there's no guarantee; Homelander could get wind of the attempt and kill everybody before they try something.
Vacuum Adaptation: Homelander told Stan Edgar the view of New York City is better from space, which implies that Homelander has flown far beyond the Earth's atmosphere without any need for oxygen to survive. This feat also confirms that he can likely survive the freezing cold of space and cosmic radiation.
Homelander's Stan Edgar Fear Nearly Cost Him the Soldier Boy Fight. This blatant rejection from his father figure also made the leader of The Seven much weaker when he faced off against Butcher and Soldier Boy – Homelander's real father. Homelander did a great job of hiding his feelings from Stan Edgar.
In the comics, Homelander doesn't really have any weaknesses either. This allows him to get away with terrorizing people and rampant murder. That said, Homelander does end up dying in the comics, though it isn't Billy Butcher or the other Boys who kill him. It's actually Black Noir who kills Homelander.
Spider-Man could just do what he did against Firelord, and just keep hitting him and retreating until Homelander is a dead man… And if he can get the opportunity, he could also shoot webs down his throat. No way to stop that. And given Spidey's speed, he could easily pull this off.
His martial arts and katana will be useless against Homelander, who has invulnerability. While Deadpool's skills may not do much, at least he can get a few laughs and poke fun of Homelander and his growing anger.
Given his physiology as an Eternal, Thanos, even without the Infinity Stones, could outmatch Homelander, as he's stronger and can take way more damage as he's practically invulnerable. Unlike Superman, Homelander isn't nearly as indestructible as he likely could be killed.
Homelander is similarly powerful, but doesn't have a corresponding weakness. In fact, apart from being unable to see through zinc with his X-Ray vision, The Boys has yet to reveal Homelander having any known limits to his powers.
Starr explained that the reason why he believes Homelander is the weakest character, despite physically being the strongest, is because of his desire to be loved. Being loved unconditionally loved was something Homelander never had growing up, which is why he craves it from the public.
Homelander was never going to give up easy, but Omni-Man's skill, power, and Viltrumite heritage earned him the win. Boomstick: When it comes to Superman knockoffs, Homelander had to eat his heart out. Wiz: The winner is Omni-Man.
Though Captain America is one of the most beloved Marvel superheroes, his skills and abilities may not be enough to overtake the powerful Homelander. Though his vibranium shield may be able to hold off Homelander's heat vision, Homelander's other powers may give him the edge to easily overpower Cap. ...
Kimiko also forms tight friendships with Hughie and Starlight. Though she isn't always a fan of her powers, she never hesitates to use them to protect the people she cares for. Kimiko is the strongest hero of The Boys, with heightened levels of superhuman strength, durability, speed, and reflexes.
In the comic series, Noir is revealed to be a clone of the Homelander and enhanced with Stormfront's DNA, created to replace him if he ever went rogue. Driven insane by a lack of purpose, Noir resolved to frame the Homelander for various atrocities as part of a plan to gradually drive him insane and replace him.
He has a very complicated and tense relationship with Homelander, he is one of the few people who is not afraid of him, and he even mocks him by calling him "man-child" but even with that he considers Homelander his friend.
His addiction to breast milk is a symptom of growing up in the Vought lab where he never had access to motherly affection and the opportunity to form a loving bond at a young age. Homelander's trauma manifested in his kink for breast milk and need for a dominant mother figure.
He knew that the odds of Soldier Boy surviving whatever was to come would be high, and that his chance of return would be inevitable. Knowing this, it would make sense for Noir to align himself with someone of great strength. His alliance with Homelander is likely deliberate and motivated by survival.