According to an fMRI study, decreased brain activity in the hippocampus was reported82 in depressive patients. Reduced gray matter volume and reduced functional activity in the hippocampus would lead to negative emotion and the inability of cognitive processing in depressive patients.
Depression may cause the release of glucocorticoid in the brain, a type of steroid that can damage the hippocampus and other areas of the central nervous system. When this occurs, you may experience symptoms associated with neurocognitive disorder (dementia), such as memory loss.
Dendrites are cellular extensions found in the neurons, or nerve cells. This suggests that depression is not an irreversible neurodegenerative disorder. Instead, its impact on the brain may be reversible, and the brain can heal.
It can impair your attention and memory, as well as your information processing and decision-making skills. It can also lower your cognitive flexibility (the ability to adapt your goals and strategies to changing situations) and executive functioning (the ability to take all the steps to get something done).
The main subcortical limbic brain regions implicated in depression are the amygdala, hippocampus, and the dorsomedial thalamus. Both structural and functional abnormalities in these areas have been found in depression. Decreased hippocampal volumes (10, 25) have been noted in subjects with depression.
If the symptoms develop later or gradually, they may constitute a relapse of the depression. Ultimately, these withdrawal symptoms will improve with time, but they can be unpleasant for days and possibly even weeks. In time, the brain readjusts and people should experience a return to their normal state.
Research suggests that depression doesn't spring from simply having too much or too little of certain brain chemicals. Rather, there are many possible causes of depression, including faulty mood regulation by the brain, genetic vulnerability, and stressful life events.
However, there is also a lot of research that shows that depression actively leads to a detrimental development of the frontal lobe, ultimately affecting your intelligence and lowering your IQ because you're simply too depressed to think straight, or can't complete certain cognitive tasks anymore.
People with clinical depression often have increased levels of monoamine oxidase A (MAO-A), an enzyme that breaks down key neurotransmitters, resulting in very low levels of serotonin, dopamine and norepinephrine.
Plus, whether you're fixating on the past or catastrophizing about the future, thought patterns that are more destructive than constructive can take a toll on both your mental health and physical health. "Studies show that ruminating on stressful events can, over time, lead to anxiety and depression," warns Dr. Fowler.
Depression and mood disorders are characterized by structural as well as neurochemical alterations in the brain. However, these changes are not permanent, and can be blocked or reversed with behavioral and pharmacological treatments.
However, taken together, the results of studies carried out in the general population and in patients with AMI strongly suggest that depression is a significant risk factor for sudden death.
If you keep taking your medicine, there is a good chance that you will start to feel less depressed and that the side effects will decrease. Most people feel that the benefits of antidepressants are well worth the price of living with some side effects.
There's no single cause of depression. It can occur for a variety of reasons and it has many different triggers. For some people, an upsetting or stressful life event, such as bereavement, divorce, illness, redundancy and job or money worries, can be the cause. Different causes can often combine to trigger depression.
The simple answer: Yes. In fact, trouble making decisions is one of the most common psychological symptoms of depression. Other depression symptoms — such as difficulty concentrating and lack of motivation — can make decision making even harder.
Our results indicate that depressive symptoms are associated with (1) spending less time in social interaction, (2) spending time with similarly depressed others, (3) spending time in pair-wise interactions rather than group interactions but not with (4) spending relatively less time with friends.
Depression has been linked to memory problems, such as forgetfulness or confusion. It can also make it difficult to focus on work or other tasks, make decisions, or think clearly. Stress and anxiety can also lead to poor memory. Depression is associated with short-term memory loss.
A dopamine imbalance can cause depression symptoms, such as apathy and feelings of hopelessness, while a serotonin imbalance can affect the processing of emotions.
And in 2011, the Black Dog Campaign began in the United Kingdom to raise awareness and resources for those living with depression. The symbolism is that of a sullen dog that a person is struggling to get off their backs. It links back to the idea of dogs guarding the afterlife and an absence of color and light.
Studies have shown that as many as 85% to 90% of the public believes that depression is caused by low serotonin levels or a chemical imbalance. Researchers have found no clear evidence that serotonin levels or activity cause depression, according to a review of prior research published in Molecular Psychiatry.
For people with chronic or severe depression, medication may be needed on a long-term basis. In these cases, antidepressants are often taken indefinitely. That is, in part, because depression is not an illness that can be cured.