These include fibromyalgia and vitamin B12 deficiency, muscular dystrophy (MD), amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), migraine, hypo-thyroidism, hypertension, Beçhets, Arnold-Chiari deformity, and mitochondrial disorders, although your neurologist can usually rule them out quite easily.
Misinterpretation of abnormal MRI findings is a frequent contributor to misdiagnosis of MS. One study found that only 11% of patients who were referred to a MS subspecialty center based primarily on an abnormal MRI were subsequently diagnosed with MS.
Some of the most common mimics include migraine and chronic cerebrovascular disease, according to Dr Schiess. Vasculitic autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's syndrome can also result in white matter abnormalities on MRI.
Although MRI is a very useful diagnostic tool, a normal MRI of the brain does not rule out the possibility of MS. About 5 percent of people who are confirmed to have MS do not initially have brain lesions evidenced by MRI.
False Results
MRI leads to false negatives—i.e., results that say MS is not present when it really is—in about 5% of MS cases. Other times, age-related damage or other conditions (migraine, brain trauma) look like MS lesions. This produces false positives, or results that indicate MS when it's not there.
But despite some similarities, “for the most part, there is no mistaking symptoms of MS with fibromyalgia,” says Philip Cohen, MD, a rheumatologist, professor of medicine and professor of microbiology and immunology at the Lewis Katz School of Medicine at Temple University in Philadelphia.
a full neurological examination. MRI scans of the brain, spine or both to look for MS plaques. a spinal tap to look for signs of inflammation and certain immune proteins that are often present in people with MS. blood tests to rule out other disorders.
Those symptoms include loss of vision in an eye, loss of power in an arm or leg or a rising sense of numbness in the legs. Other common symptoms associated with MS include spasms, fatigue, depression, incontinence issues, sexual dysfunction, and walking difficulties.
Answer & Explanation. The statement that is NOT true about multiple sclerosis (MS) is: b. MS results in destruction of the myelin sheaths of axons primarily in the peripheral nervous system.
Blood Tests: Currently, there are no definitive blood tests for diagnosing MS, but they can be used to rule out other conditions that may mimic MS symptoms, including Lyme disease, collagen-vascular diseases, rare hereditary disorders and acquired immune deficiency syndrome (AIDS).
Abnormal sensations can be a common initial symptom of MS. This often takes the form of numbness or tingling in different parts of your body, such as the arms, legs or trunk, which typically spreads out over a few days.
Sjogren's syndrome is an autoimmune disease that can mimic some of the symptoms of MS such as fatigue and joint pain.
Neurological examination
Your neurologist will look for abnormalities, changes or weakness in your vision, eye movements, hand or leg strength, balance and co-ordination, speech and reflexes. These may show whether your nerves are damaged in a way that might suggest MS.
Here's where MS (typically) starts
Although a number of MS symptoms can appear early on, two stand out as occurring more often than others: Optic neuritis, or inflammation of the optic nerve, is usually the most common, Shoemaker says. You may experience eye pain, blurred vision and headache.
What Does MS Feels Like? A lack of feeling or a pins-and-needles sensation can be the first sign of nerve damage from MS. It usually happens in your face, arms, or legs, and on one side of your body. It tends to go away on its own.
MRI plays a vital role in how we diagnose and monitor MS. In fact, over 90% of people have their MS diagnosis confirmed by MRI.
The symptoms can be similar, but people with fibromyalgia are more likely to experience depression, irritable bowel syndrome, and widespread, persistent pain. Symptoms more common with MS include weakness, vision problems, muscle spasms, and bowel or bladder issues.
Neuropathic pain happens from “short circuiting” of the nerves that carry signals from the brain to the body because of damage from MS. These pain sensations feel like burning, stabbing, sharp and squeezing sensations.
An MS hug usually lasts for a few seconds or minutes, but it can last for hours or even longer. MS hugs can be unpredictable, tiring and stressful.
Dawson's finger is a type of brain lesion common to people who have MS. These lesions develop on the ventricles, or fluid-filled spaces in the brain. Dawson's finger lesions can help a doctor diagnose multiple sclerosis (MS) when other symptoms, such as difficulties with movement or thought processes, accompany them.
Sometimes an MRI reviewed by a radiologist can provide enough evidence to make a diagnosis. But in the case of MS, it takes a combination of the MRI with the patient's clinical symptoms, history, and neurological examination to make the diagnosis.
Other causes
Other types of demyelinating disease and their causes include: Optic neuritis — inflammation of the optic nerve in one or both eyes. Neuromyelitis optica spectrum disorder (NMOSD) — inflammation and demyelination of the central nervous system, especially of the optic nerve and spinal cord.