"Loneliness can change the neurochemistry of the brain, turning off the dopamine neurons, which trigger the reward response, and causing some degeneration in the brain when the reward response is not activated," says Katherine Peters, MD, PhD, FAAN, associate professor of neurology and neurosurgery at Duke University.
"Lacking encouragement from family or friends, those who are lonely may slide into unhealthy habits," Valtorta says. "In addition, loneliness has been found to raise levels of stress, impede sleep and, in turn, harm the body. Loneliness can also augment depression or anxiety."
The brains of lonely people tend to show different patterns of activation when they think about themselves and others (even people close to them), and lower levels of activity in the medial prefrontal cortex compared to non-lonely people, a 2019 study found.
Significant loneliness by age interactions were found for dlPFC, amygdala, hippocampus, and anterior cingulate cortex. Loneliness by depression interaction were revealed in dlPFC and insula.
A report from the National Academies of Sciences, Engineering, and Medicine (NASEM) points out that more than one-third of adults aged 45 and older feel lonely, and nearly one-fourth of adults aged 65 and older are considered to be socially isolated.
Research has linked social isolation and loneliness to higher risks for a variety of physical and mental conditions: high blood pressure, heart disease, obesity, a weakened immune system, anxiety, depression, cognitive decline, Alzheimer's disease, and even death.
Feeling lonely can also have a negative impact on your mental health, especially if these feelings have lasted a long time. Some research suggests that loneliness is associated with an increased risk of certain mental health problems, including depression, anxiety, low self-esteem, sleep problems and increased stress.
These feelings of loneliness may ultimately lead to posttraumatic stress symptoms via a number of pathways. For example, loneliness may lead to the development of negative cognitions (Cacioppo and Hawkley, 2009), which can predict future PTSD symptoms and impact PTSD treatment (Brown et al., 2019).
If you're lonely, you may feel sad, empty, or as if you're lacking something important when you spend time by yourself. Chronic loneliness can also involve the following symptoms: decreased energy. feeling foggy or unable to focus.
A cure for loneliness may be closer than you think as Cacioppo found that pregnenolone (a steroid naturally made in the body) can help combat the anxiety that comes with feelings of loneliness.
It is not surprising that loneliness hurts. A brain imaging study showed that feeling ostracized actually activates our neural pain matrix. In fact, several studies show that ostracizing others hurts us as much as being ostracized ourselves.
At the moment, unlike depression and anxiety, loneliness has no recognized clinical form. Respectively, there is no available diagnosis or treatment for feeling chronically isolated.
Loneliness is toxic
Loneliness has clear consequences for mental health, aggravating anxiety, depression, and stress-related symptoms. Additionally, it sabotages our physical health. According to two leading researchers, loneliness triggers an inflammatory response and threatens our immune system.
Borderline personality disorder is characterized by loneliness, social isolation, a fear of abandonment, poor social and communication skills, and unstable, difficult interpersonal relationships. The loneliness of living with this condition can be extremely painful, but treatments can be effective.
Loneliness is associated with higher blood pressure and heart disease — it literally breaks our hearts. A 2015 meta-review of 70 studies showed that loneliness increases the risk of your chance of dying by 26 percent.
If you have schizoid personality disorder, you may be seen as a loner or dismissive of others, and you may lack the desire or skill to form close personal relationships. Because you don't tend to show emotion, you may appear as though you don't care about others or what's going on around you.
Biologists have shown that feelings of loneliness trigger the release of stress hormones that in turn are associated with higher blood pressure, decreased resistance to infection and increased risk of cardiovascular disease and cancer.
Some of the most common causes of loneliness include: Social Anxiety, Isolation, Difficulty with Assertiveness, and Poor Self-awareness. Common types or forms of loneliness include: Lack of Physical Connection, Lack of Common Interests, Lack of Shared Values, Lack of Emotional Intimacy, and Lack of Self-Intimacy.
Loneliness hurts on so many levels and increases a person's risk of developing mental health conditions such as depression or anxiety. It may also lead to heart disease, heart attacks, or stroke, which makes dealing with loneliness essential to our long-term health.
A lot of mental illnesses like bipolar, anxiety and depression can all make people feel very lonely. Mental illness can make you anxious about seeing others, so you might spend more time indoors. Or it can lead to insomnia, which in turn can make you tired, irritable and lonely.
Most notably, researchers found that loneliness rates peak among people in their 20s, and reach their lowest point among those in their 60s. Many people also experience a spike in lonely feelings around their mid-40s. These findings are as confounding as they are surprising, at least initially.
Loneliness causes people to feel empty, alone, and unwanted. People who are lonely often crave human contact, but their state of mind makes it more difficult to form connections with other people. Loneliness, according to many experts, is not necessarily about being alone.
It may take some time, but it's very possible to build new relationships or deepen existing connections in your life. If you aren't sure what you can do to feel less lonely, consider reaching out to a therapist who can offer help and support.