The remaining 50% of the dietary xylitol thus enters the colon where it can serve as an energy and carbon source for the intestinal microbiota and leads to the formation of short-chain fatty acids which provide energy to the host and support immune system homeostasis [24].
Based on the cross-feeding and competition among those bacteria, xylitol can dynamically balance proportions of the gut microbiome to promote enzymes related to xylitol metabolism and SCFAs.
Xylitol targets s. mutans (streptococcus mutans). This strain takes xylitol into the cell to be metabolized into a phosphate, becoming toxic to bacteria. Amazingly, the positive bacteria we want to keep in our guts seemed to be relatively unaffected, according to studies done using xylitol and sorbitol chewing gum.
Xylitol helps in glycemic and obesity control; reduces ear and respiratory infections. Xylitol treats diseases that cannot be cured through antibiotics or by surgery.
It is possibly safe when used in chewing gums, candies, lozenges, toothpastes, and mouth rinses in amounts up to about 50 grams daily. It might cause diarrhea and gas in some people. Taking high doses of xylitol is possibly unsafe. Using very high doses long-term might cause tumors.
Due to differing amounts of xylitol present in various products, the amount of a product that is needed to be ingested before toxicity is expected varies. In general, lower doses of xylitol cause hypoglycemia, while higher doses cause liver failure.
In addition, xylitol has anti-inflammatory effects by inhibiting the production of cytokines induced by P. gingivalis LPS in Raw 264.7 cells.
Xylitol also has a low GI, which makes it an attractive alternative to sugar for people wishing to lose weight and those with diabetes. Some research also suggests that xylitol has antibacterial properties that can help prevent tooth decay, gum disease, and ear infections.
Plasma CCK: Xylitol leads to a dose-dependent increase in plasma CCK concentrations compared to placebo.
High doses of xylitol ingested by humans can cause gastrointestinal discomfort, irritable bowel syndrome, and diarrhea. Xylitol can also cause an increase in the level of phosphate, oxalate, and calcium excretion in urine which may increase the risk of kidney stones.
However, what makes xylitol so great is that while the bacteria will still eat it, it doesn't fuel them. Instead, xylitol actually starves the bacteria. In fact, xylitol can effectively lower bacteria levels, sometimes up to 75%.
In addition, since this natural sugar slows destruction caused by bacteria, it not only prevents new cavities from forming but can also work towards rebuilding enamel and reversing the tooth decay that has already occurred.
Chewing gum comparisons showed that 100-percent xylitol-sweetened chewing gum reduced plaque accumulation significantly better than 100-percent sorbitol-sweetened gum and better than a gum sweetened with both xylitol and sorbitol.
Xylitol is a high FODMAP sugar alcohol (polyol), that can wreak havoc on our digestive systems and trigger IBS symptoms.
It is often used by diabetics to help maintain stable blood sugar levels. As part of your Candida diet, it will restrict the amount of sugar that the Candida cells in your gut require to grow. Together with probiotics and antifungals, Xylitol can be a useful addition to your Candida diet.
Xylitol is considered a sugar substitute, but far from being an appetite suppressant, it may cause you to eat more. Eating regular sugar, and the consequent spike in blood sugar that follows, are part of your body's natural mechanism of satiety, or the feeling of fullness that tells you when to stop eating.
Clinical signs of toxicity manifest as serotonin‐like syndrome, and include neurologic signs such as seizures, depression, tremors, hyperesthesia, ataxia, paresis, disorientation, mydriasis, and coma; and gastrointestinal signs such as vomiting, diarrhea, abdominal pain, hypersalivation, flatulence, and bloat.
BAKING SODA AND/ OR XYLITOL RINSES
Baking soda is great for raising our ph. Our ph is most acidic at 2 am (because of our physiological cycle), so raising your ph before bed is important for good oral hygiene. Xylitol also raises the ph in our mouth and makes the bacteria to starve.
Xylitol helps repair tooth enamel?? It's true. In a 2-year study among children in Montreal, the kids who used xylitol chewing gum were found to have a significantly higher number of reversals of cavities than the kids who did not use it.
Caused by poor oral hygiene and accumulation of plaque, gingivitis may lead to receding gum lines, swollen gums, and periodontitis (severe gum disease) if left untreated. Research into the ability of xylitol to reverse gum disease indicates that it may help reduce mild or early-stage gingivitis.
Xylitol side effects also include constipation, gas, bloating, diarrhea, nausea, borborygmi, colic, increased bowel movements and weight gain. Potential xylitol benefits including aiding in oral health, since some research shows it does have the ability to prevent cavities.
Xylitol has been shown to display virucidal effects against SARS-CoV-2 and with the addition of hypertonic saline and hyaluronate may shorten the viral shedding duration in asymptomatic COVID-19 positive subjects [16, 17].
Xylitol also modulates the immune system, which, together with its antimicrobial activity contribute to a reduced respiratory tract infection, sinusitis, and otitis media risk. As a low caloric sweetener, xylitol may contribute to weight management.
Overall, both xylitol and L-pyroglutamic acid increased by high humidity could aggravate arthritis, but these effects depended on the administration time and dose of them.