Diazepam is better absorbed after oral than after i.m. administrations but this does not apply to lorazepam. The clinical effect and amnesia begin more rapidly with diazepam, but last longer following lorazepam. Lorazepam is more effective than diazepam in blocking the emergence sequelae from ketamine.
As a sedative, in single doses, midazolam is considered to be three times more potent than diazepam. With multiple doses midazolam gains in potency because of a prolonged plasma half-life.
The central difference between lorazepam and diazepam is lorazepam leaves a person's system more quickly, reducing the chance of toxicity or side effects.
Temazepam 10mg is approximately equivalent to diazepam 5mg. Temazepam is used short-term for the treatment of insomnia, and as pre-medication before minor surgical and investigative procedures. The dose is taken at bedtime (for insomnia), or half to one hour before the procedure (as pre-medication).
For its high-potency and long-lasting effects, the most potent benzodiazepine is Clonazepam, also known as Klonopin. Other high-potency but short-acting benzos are alprazolam (Xanax), lorazepam (Ativan), and triazolam (Halcion).
Diazepam tablets are available in three strengths: 2 mg, 5 mg, and 10 mg.
The most prominent of anti-anxiety drugs for the purpose of immediate relief are those known as benzodiazepines; among them are alprazolam (Xanax), clonazepam (Klonopin), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan).
SSRIs and SNRIs are often the first-line treatment for anxiety. Common SSRI brands are Celexa, Lexapro, Luvox, Paxil, and Zoloft. Common SNRI brands are Pristiq, Cymbalta, and Effexor XR. Pros: They are effective for a lot of people and they have a solid safety profile.
Whilst most people find benzodiazepines like diazepam sedating, a small number have paradoxical agitation and in aggression. They can also cause disinhibition and lead you to behave in a way that you would not normally.
Vistaril® (Hydroxyzine)
Hydroxyzine is a fast-acting drug that is very effective in treating anxiety temporarily. It sometimes has the side effect of sedation, but this wears off the longer you take it. Hydroxyzine works by blocking the histamine receptor.
The usual dose is: anxiety – 2mg, taken 3 times a day, this can be increased to 5mg to 10mg, taken 3 times a day. sleep problems (related to anxiety) – 5mg to 15mg, taken once a day at bedtime. muscle spasms in adults – 2mg to 15 mg a day.
With sustained levels of anxiety, long-acting benzodiazepines such as diazepam and clorazepate are usually preferred, while episodic anxiety normally responds best to shorter-acting drugs such as oxazepam or lorazepam.
Antipsychotics are commonly prescribed to help with symptoms such as hallucinations, delusions, or racing thoughts, but can also be prescribed for individuals without those symptoms. Some antipsychotics are considered mood stabilizers because they, too, even out the highs and lows.
Stimulants. Improve fatigue and concentration. These drugs include methylphenidate (Ritalin, Concerta).
There may be several reasons why an anxiety medication is not working. A patient may have co-morbid conditions or they may not be taking the medication as prescribed. Or, anxiety symptoms may be due to an underlying and untreated biological cause, such as a bacterial or viral infection.
Panic disorder involves repeated episodes of sudden feelings of intense anxiety and fear or terror that reach a peak within minutes (panic attacks). You may have feelings of impending doom, shortness of breath, chest pain, or a rapid, fluttering or pounding heart (heart palpitations).
Doctors generally recommend the drug should be used at dosages of 2-10 mg. This amount can be taken up to four times in a 24-hour time frame. The maximum daily total use in milligrams should not exceed 40 mg.
You should not normally be prescribed diazepam for more than four weeks. If you are taking diazepam to help you sleep, you should take it just before bedtime. Diazepam can be taken before or after food. Swallow tablets whole with a drink of water – if chewed, they taste bitter.
Adults: Usual dose: 2 mg three times daily. Maximum dose: Up to 30 mg daily in divided doses. Adjusted on an individual basis. Insomnia associated with anxiety: 5 to 15 mg before retiring.
Zolpidem 10 mg provided greater subjective hypnotic efficacy than temazepam 15 mg in this model of transient insomnia, with reduced polysomnographic awakenings and WASO. Impairment of DSST was seen with zolpidem but not temazepam.
Z-drugs and benzodiazepines
Z-drugs like zolpidem (Ambien) and zaleplon (Sonata) are commonly prescribed to help you fall asleep, especially if you don't have chronic insomnia. They can be taken as needed and usually work within an hour. Benzodiazepines are another option.