Ivermectin and other related drugs (milbemycin, selamectin) are commonly used in the prevention and treatment of parasites. They are common components of most canine heartworm preventives. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation.
These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. However, not all ML's are created equal, and some are safer than others.
In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose.
The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. Dogs with the MDR1 mutation are not at increased risk for adverse effects.
Multidrug-resistant mutation (MDR1) is a genetic mutation that makes dogs sensitive to the negative effects of some medications. Common medications like Ivermectin, Loperamide, and several sedatives can have stronger effects in dogs with MDR1. Bravecto is safe for MDR1 dogs and studies did not show any adverse effects.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
Drugs such as ivermectin, selamectin, milbemycin, and moxidectin, are commonly used to treat and prevent parasites like heartworms. At low doses, such as those used in heartworm prevention, these drugs have been shown to be safe even for dogs with the MDR1 mutation.
Frontline Plus is the best flea and tick treatment for the outdoor-loving Border Collie. Featuring the combined abilities of Fipronil and S-Methoprene, it aims to eliminate a flea and tick infestation once and for all. Fipronil is a fast-acting insecticide that disrupts the nerve receptors of adult fleas and ticks.
Ivermectin and other related drugs (milbemycin, selamectin) are commonly used in the prevention and treatment of parasites. They are common components of most canine heartworm preventives. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation.
Cedar oil is a good replacement for flea medications for dogs like Bravecto Chews for Dogs, Frontline Plus for Dogs, Revolution for Dogs, Simparica for Dogs, Advantage Multi for Dogs, and more.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio. But while Simparica is usually safe flea and tick treatment for dogs, it shouldn't be prescribed to dogs with a history of seizures.
If chemical products are necessary for additional flea or tick control, NRDC recommends s-methoprene or pyriproxyfen, which are less toxic ingredients—but read the labels carefully because some products use them with other, more harmful pesticides.
Are NexGard and NexGard SPECTRA safe to use for any breed of dog? NexGard and NexGard SPECTRA have been shown to be safe and effective in various breeds of dogs (including Collie breeds) when used as directed and, can be given to puppies from 8 weeks of age, providing they weigh at least 2 kg.
The MDR1 mutation has also been found in Shetland sheepdogs (Shelties), Australian shepherds, old English sheepdogs, English shepherds, German shepherds, long-haired whippets, silken windhounds, and a variety of mixed-breed dogs.
MDR1 is an autosomal dominant genetic disorder, which means that only one copy of the gene is necessary for the dog to be affected. There is therefore no such thing as an MDR1 carrier.
The main differences between the two are the strength and speed at which the products work, with Simparica killing fleas in little as 3 hours and ticks within 8. Nexgard offers a 4 hour time frame for killing fleas while killing ticks in 24 hours.
An oral fast-acting tablet that contains Nitenpyram is the safest way to kill fleas on dogs instantly. You can also bathe your dog in hot soapy water with Dawn to kill adult fleas, but this is not a good long-term solution.
Afoxolaner (the generic name for the brand name Nexgard) is the active ingredient in Nexgard Chewables. The monthly medication helps effectively control and prevent adult flea infections before they start laying eggs.
The only downside to NexGard is that the parasites have to bite the dog to be affected by the medication, which can sometimes take several hours to take place. We'll contact your Vet to verify.
If your dog isn't protected, a single bite from a tiny tick can make them very sick. A dose of NexGard kills ticks fast, all month long, and it's FDA-approved to prevent the infections that cause Lyme disease by killing blacked-legged ticks. NexGard chews are #1 vet-recommended for a reason.
As with any oral medication, vomiting, diarrhea, allergic or neurological reactions can occur. While we take all adverse reactions very seriously, our doctors have actually seen less reactions with oral Nexgard than with other topical flea and tick prevention options.