Sepsis is the body's extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Infections that lead to sepsis most often start in the lung, urinary tract, skin, or gastrointestinal tract.
The following are signs you have a serious infection: Severe headache. Constant vomiting. Bloodstained vomit, stool, or urine.
Sepsis can be divided into three stages: sepsis, severe sepsis and septic shock.
When treatment or medical intervention is missing, sepsis is a leading cause of death, more significant than breast cancer, lung cancer, or heart attack. Research shows that the condition can kill an affected person in as little as 12 hours.
Sepsis is well known to cause a high patient death rate (up to 50%) during the intensive care unit (ICU) stay.
The first signs may include rapid breathing and confusion. Other common symptoms include: Fever and chills. Very low body temperature.
Staphylococcus aureus (MRSA)
Probably the most famous hospital-acquired infection or 'superbug', MRSA is so-called because of its resistance to the antibiotic methicillin (hence Methicillin Resistant Staphylococcus Aureas).
As severe sepsis usually involves infection of the bloodstream, the heart is one of the first affected organs.
Early symptoms include fever and feeling unwell, faint, weak, or confused. You may notice your heart rate and breathing are faster than usual. If it's not treated, sepsis can harm your organs, make it hard to breathe, and mess up your thinking.
High heart rate or weak pulse. Fever, shivering, or feeling very cold. Confusion or disorientation. Shortness of breath.
Resistance to even one antibiotic can mean serious problems. For example: Antimicrobial-resistant infections that require the use of second- and third-line treatments can harm patients by causing serious side effects, such as organ failure, and prolong care and recovery, sometimes for months.
“If there is fever, rapidly spreading redness, rapid heart rate, or extraordinary pain that is disproportionate to the wound or injury, that is when you tell the patient to visit the hospital,” he said.
The final stage of infection is known as convalescence. During this stage, symptoms resolve, and a person can return to their normal functions. Depending on the severity of the infection, some people may have permanent damage even after the infection resolves.
If the infection has spread or you have a generalized infection, you may develop other signs and symptoms, such as fever, fatigue, pain, etc. Sometimes however, you may have an infection and not know it, and not have any symptoms.
You may need to stay in hospital for several weeks.
Blood tests may reveal the following signs suggestive of sepsis: Elevated or low white blood cells – Higher than usual levels of leukocytes, known as white blood cells (WBCs), are a sign of a current infection, while too few WBCs indicate that a person is at higher risk of developing one.
As sepsis worsens or septic shock develops, an early sign, particularly in older people or the very young, may be confusion or decreased alertness. Blood pressure decreases, yet the skin is paradoxically warm. Later, extremities become cool and pale, with peripheral cyanosis and mottling.
Signs of sepsis are: • Pale, blotchy or blue skin, lips or tongue. Blotchy skin is when parts of your skin are a different colour than normal. Sometimes it is hard to know if you or somebody you look after has sepsis, or if it is something else, like flu or a chest infection.
Sepsis was once commonly known as “blood poisoning.” It was almost always deadly. Today, even with early treatment, sepsis kills about 1 in 5 affected people. It causes symptoms such as fever, chills, rapid breathing, and confusion.
Bacterial infections cause most cases of sepsis. Sepsis can also be a result of other infections, including viral infections, such as COVID-19 or influenza, or fungal infections.