If left untreated, the disease will lead to death. If you decline life-saving treatment, you can choose to get support from palliative care (a medical team that manages your symptoms and pain).
"Some patients can be in watch-and-wait mode for 10 years or more." It's possible you'll never need treatment. There's no way to know for sure if you'll eventually need treatment. You may need it if your: Symptoms start up and cause problems.
Sometimes, people with follicular lymphoma have no symptoms for many years and do not need treatment. Some may never need treatment. In other people, treatment may be required for symptoms.
If you have symptoms of lymphoma or signs of infection, please contact your GP surgery or your clinical team. It is important that you don't ignore symptoms that could be serious.
Common symptoms of having lymphoma include swelling of lymph nodes in your neck, in your armpits or your groin. This is often but not always painless and often could be associated with fevers, or unexplained weight loss, or drenching night sweats, sometimes chills, persistent fatigue.
Blood Tests
A low level of red blood cells, white blood cells or platelets may indicate that the lymphoma is present in the bone marrow and/or blood.
The best way to find lymphoma early is to pay attention to possible signs and symptoms. One of the most common symptoms is enlargement of one or more lymph nodes, causing a lump or bump under the skin which is usually not painful. This is most often on the side of the neck, in the armpit, or in the groin.
Lymphoma most often spreads to the liver, bone marrow, or lungs. Stage III-IV lymphomas are common, still very treatable, and often curable, depending on the NHL subtype. Stage III and stage IV are now considered a single category because they have the same treatment and prognosis.
Unlike most cancers, rates of Hodgkin lymphoma are highest among teens and young adults (ages 15 to 39 years) and again among older adults (ages 75 years or older). White people are more likely than Black people to develop non-Hodgkin lymphoma, and men are more likely than women to develop lymphoma.
If left untreated, the disease will lead to death. If you decline life-saving treatment, you can choose to get support from palliative care (a medical team that manages your symptoms and pain). Later, hospice can support you in the final 6 months to help you manage your quality of life.
Lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia.
This is a rare, slow-growing type of lymphoma. It's found mainly in the bone marrow, lymph nodes, and spleen. This type of lymphoma can't be cured. But people can live with it for many years.
Stage 4. Stage 4 is the most advanced stage of lymphoma. Lymphoma that has started in the lymph nodes and spread to at least one body organ outside the lymphatic system (for example, the lungs, liver, bone marrow or solid bones) is advanced lymphoma.
Non-Hodgkin lymphoma is usually treated with chemotherapy or radiotherapy, although some people may not need treatment straight away. In a few cases, if the initial cancer is very small and can be removed during a biopsy, no further treatment may be needed.
The changes can be gradual, but crises can develop. People with NHL most often die from infections, bleeding or organ failure resulting from metastases. A serious infection or sudden bleeding can quickly lead to death, even if someone doesn't appear very ill.
After five to 10 years, low-grade disorders begin to progress rapidly to become aggressive or high-grade and produce more severe symptoms. This type progresses fairly rapidly without treatment.
Age: Most cases occur in people older than 60. Exposure to certain chemicals, such as benzene, herbicides and pesticides, including exposure to Agent Orange or other herbicides during military service in the Vietnam War. Previous chemotherapy or radiation therapy. Radiation exposure.
The lumps may be confined to one area of the body, such as the neck, or develop in multiple areas, such as the neck, armpits and groin. Lymphoma lumps have a rubbery feel and are usually painless. While some lymphoma lumps develop within a matter of days, others can take months or even years to become noticeable.
Swollen lymph nodes, fever, and night sweats are common symptoms of lymphoma. Symptoms of lymphoma often depend on the type you have, what organs are involved, and how advanced your disease is. Some people with lymphoma will experience obvious signs of the disease, while others won't notice any changes.
Cytokines can irritate nerve endings in the skin, which can in turn cause persistent itching. Many individuals experience this itchiness in their hands, lower legs or feet, while others feel it throughout their entire body. Patients often report that the itching tends to worsen while they are lying in bed at night.
Physical exam. Your doctor checks for swollen lymph nodes, including in your neck, underarm and groin, as well as a swollen spleen or liver. Removing a lymph node for testing. Your doctor may recommend a lymph node biopsy procedure to remove all or part of a lymph node for laboratory testing.
Computed tomography (CT) scan
This scan can help tell if any lymph nodes or organs in your body are enlarged. CT scans are useful for looking for lymphoma in the abdomen, pelvis, chest, head, and neck. CT-guided needle biopsy: A CT can also be used to guide a biopsy needle into a suspicious area.
You might have an ultrasound scan to help diagnose non-Hodgkin lymphoma. Ultrasound scans are useful for looking at individual organs such as the liver and kidneys and showing any changes.
MRI: An MRI scan is helpful in detecting lymphoma that has spread to the spinal cord or brain. It can be helpful in other areas of the body as well, such as the head and neck area. Abdominal ultrasound: Abdominal ultrasound may be used to examine enlarged lymph nodes, especially in the abdomen.