Otsutsuki clan
The Otsutsuki is the most powerful clan in "Naruto," and it's really not even close. This clan literally invented shinobi, and the most prominent clans are their direct descendants. Their power is legendary, and few other than Madara even knew about them for most of "Naruto" and "Naruto: Shippuden."
Apart from the infamous Uchiha clan, the Uzumaki Clan is one of the most powerful clans in the world of Naruto. However, looking back at the anime, Naruto's Uzumaki clan is underrated even though it produced some of the most talented and formidable shinobi in the series.
canonically the senju is the strongest clan overall, sure Naruto and Sasuke as they are now are arguably stronger than any member of the senju, but overall, taking all members of the Uzumaki except Naruto and Nagato into account Uzumaki is at best on par with hyuga and far beneath Uchiha and Senju.
Obito Uchiha was one of the strongest Uchiha to ever exist. He awakened his Mangekyō Sharingan during the Third Great Ninja War after witnessing Rin die. Obito's eye weilded the Kamui, a powerful space-time ninjutsu.
2 Boruto Uzumaki
At the same time, he is the vessel of Momoshiki, and has become a complete Otsutsuki at this point in time. As such, he is extremely powerful right now and easily the second-strongest Uzumaki of all time.
Madara was great during his youth, able to keep up with Hashirama Senju (The First Hokage) and do major damage with his Susanoo. At the height of his power, he was able to slaughter entire groups of ninja, take on the Kage, and slice the tops of mountains off! Alone, Boruto wouldn't stand much of a chance.
He is dubbed by most to be the strongest shinobi in history. Sasuke himself admitted this fact. In the end, while Sasuke may not be able to beat Naruto, even with his perceived weakened state in Boruto, the two did become friends again. A combination of powers that are said to be able to destroy the entire world.
With Naruto Uzumaki, the Seventh Hokage, being considered the strongest of all time, it is quite clear that the weakest of all Hokage is one of Kakashi Hatake and Tsunade Senju.
Hashirama Senju
He was the only one capable of defeating Madara Uchiha during the latter's early life. After his death and resurrection, Madara gained access to powers he could never gain in life. However, the First Hokage did famously beat and seemingly kill Madara in a duel at the Final Valley.
Madara Uchiha is a legendary ninja with immense skill and chakra, and during the 4th Great Ninja War, he proved to be stronger than Sasuke. He possesses far more battle experience, and his Fire-Style ninjutsu was powerful enough to bathe an entire battlefield in fire.
Sasuke is yet another strong character in the Naruto series who eventually surpassed Kakashi. Sasuke was so strong that he was able to perform jutsus like Indra's Arrow which has similar, if not the same destructive capabilities compared to Naruto's Six Paths: Ultra Big Ball Rasenshuriken.
Jiraiya. Jiraiya was an exceptionally competent shinobi, and he was the only member of the Legendary Sannin who could actually beat Itachi. He was trained by the Third Hokage, and learned how to use Sage Mode while training with the toads of Mount Myoboku.
Naruto and Sasuke are arguably the most powerful characters by the end of the Naruto Shippuden anime, so it goes without saying that Might Guy would stand no chance against Naruto in his Sage of Six Paths mode, or against Sasuke using his Rinnegan.
Even though Boruto's body isn't fully Otsutsukified, Momoshiki Otsutsuki remains far stronger than Naruto without the aid of Kurama.
Who is the god of Uchiha? Indra Otsutsuki is revealed to be the creator/ founder of the renowned Uchiha Clan in Naruto. He was the eldest son of Hagoromo Otsutsuki (The Sage of Six Paths) and the elder brother of Ashura Otsutsuki.
Obito Uchiha is one of the main antagonists of the Naruto franchise. He is a member of Konohagakure's Uchiha clan who was believed to have died during the Third Shinobi World War, his only surviving legacy being the Sharingan he entrusted to his teammate, Kakashi Hatake.
8 Obito Uchiha, The Second Ten-Tails Jinchuriki
The First Hokage, Hashirama Senju, openly admitted to being inferior to him. Given that the Five Kage are weaker than both Hashirama and Madara, they would certainly not have stood any chance against Obito either.
Obito becomes the Ten-Tails host but is defeated by Naruto and Sasuke with the support of the Allied Shinobi Forces. A guilt-ridden Obito tries to revive everyone who died in the war, like Nagato before him, only to be possessed by Black Zetsu and forced to resurrect Madara.