In the most severe forms of SLE, the kidney and the central nervous systems are affected (23). The patients with renal lupus will present with abnormalities in the urine (blood and/or protein in the urine) and oftentimes edema.
SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels.
Lupus is an autoimmune disease link—a disorder in which the body's immune system attacks the body's own cells and organs. Kidney disease caused by lupus may get worse over time and lead to kidney failure. If your kidneys fail, you will need dialysis or a kidney transplant to maintain your health.
SLE is a multisystem disease with several phenotypes. Clinical features may vary from a very mild disease with only mucocutaneous involvement to severe life-threatening disease with multiorgan involvement. All organ systems can be involved in SLE.
Kidneys About one half of people with lupus experience kidney involvement, and the kidney has become the most extensively studied organ affected by lupus.
Liver involvement in systemic lupus erythematosus (SLE) often manifests as abnormal liver enzymes [1,2]. The causes of liver function abnormalities in lupus are often secondary to drug toxicity, comorbidities like fatty liver, as well as chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections [3-5].
The kidney is the most commonly involved visceral organ in SLE. Although only approximately 50% of patients with SLE develop clinically evident renal disease, biopsy studies demonstrate some degree of renal involvement in almost all patients.
Lupus is a disease that occurs when your body's immune system attacks your own tissues and organs (autoimmune disease). Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs.
CVD as the underlying cause of death was 3.63 times higher among SLE cases than in the general population. CVD deaths for those with SLE were nearly 4 and 6 times higher for Asian and Hispanic individuals with SLE, respectively, compared to the general population.
According to the Lupus Research Alliance, about half of all people with lupus experience cognitive difficulties with thought processes. Around 1 in 5 people experience headaches, memory loss, mood swings, and stroke. Blood clots might also develop. These might also lead to dangerous complications, such as stroke.
With close follow-up and treatment, 80-90% of people with lupus can expect to live a normal life span. It is true that medical science has not yet developed a method for curing lupus, and some people do die from the disease. However, for the majority of people living with the disease today, it will not be fatal.
As many as half of adults with systemic lupus develop lupus nephritis. Systemic lupus causes immune system proteins to damage the kidneys, harming their ability to filter out waste.
Lupus can also cause hepatic vasculitis, or inflammation of the blood vessels that carry blood to the liver. This can cause blood clots and other problems.
An enlarged spleen (splenomegaly) is a common symptom of lupus, occurring in 10 percent to 46 percent of those with active disease. It is generally caused by blood abnormalities caused by the inflammation of lupus.
Lupus can slow the digestive process, and this can cause a wide variety of GI issues. Digestive problems may be the direct result of an attack by the immune system or from medications to treat lupus. These digestive difficulties include nausea, vomiting, diarrhea, or constipation.
Many people with lupus sometimes have confusion, memory loss, and trouble expressing thoughts. The medical term is cognitive dysfunction. These symptoms can come and go. Lupus brain fog can be frustrating, but you can learn to live with your symptoms and improve your quality of life.
Lupus is a chronic inflammatory autoimmune disease with a wide range of clinical presentations resulting from its effect on multiple organ systems. There are four main types of lupus: neonatal, discoid, drug-induced, and systemic lupus erythematosus (SLE), the type that affects the majority of patients.
As a rare complication of SLE, acute pancreatitis presents as generalized flare-ups in most cases of patients previously diagnosed with SLE.
Virtually every system and organ can be affected by SLE. Gastrointestinal symptoms are common in SLE patients, and more than half of them are caused by adverse reactions to medications and viral or bacterial infections.
Clinical manifestations of SLE IPO include abdominal pain and distension, nausea, vomiting, constipation, and/or diarrhea. On plain abdominal radiographs, there are multiple air-fluid levels, dilated bowel loops (often of the small bowel), and possibly thickened bowel walls.
Systemic lupus erythematosus (SLE) is the most common and most serious type of lupus. SLE affects all parts of the body.
With age, symptom activity with lupus often declines, but symptoms you already have may grow more severe. The accumulation of damage over years may result in the need for joint replacements or other treatments.
The vast majority of people diagnosed with the condition will have a normal or near-normal life expectancy. However, some people with SLE are still at risk of life-threatening complications as a result of damage to internal organs and tissues, such as heart attack or stroke.