Most people develop symptoms of ankylosing spondylitis before age 45. However, some people develop the disease when they are children or teens. Other conditions.
Early symptoms of ankylosing spondylitis might include back pain and stiffness in the lower back and hips, especially in the morning and after periods of inactivity. Neck pain and fatigue also are common. Over time, symptoms might worsen, improve or stop at irregular intervals.
Whether it's through physical therapy or on your own, dedicating time to stretching is key. “We recommend making sure that you maintain your flexibility,” says Dr. Elghawy. “And so doing with physical therapy or flexibility exercises on your own for your low back can provide a lot of relief.”
Ankylosing spondylitis is more common in men. The disease can occur at any age; however, onset generally occurs in late adolescence or early adulthood, between the ages of about 20 and 40.
If you have ankylosing spondylitis, you may have pain and stiffness at night, in the morning, or when you're not active. The pain may begin in the joints between your pelvis and spine and then move along your spine. Your pain may get better with movement or exercise.
Over time this can damage the spine and lead to the growth of new bone. In some cases this can cause parts of the spine to join up (fuse) and lose flexibility (ankylosis). It's not known exactly what causes AS, but in many cases there seems to be a link with a particular gene variant known as HLA-B27.
Ankylosing spondylitis is a chronic, inflammatory disorder and a rare form of arthritis. Triggers for ankylosing spondylitis include infections (gastrointestinal infections, urinary tract infections [UTIs], and respiratory infections), heavy physical activity, work stress, emotional stress, and pregnancy.
Ankylosing spondylitis may affect more than the spine. The disease may inflame joints in the pelvis, shoulders, hips and knees, and between the spine and ribs.
Some people with AS are able to remain fully independent or minimally disabled in the long term. However, some people eventually become severely disabled as a result of the bones in their spine fusing in a fixed position and damage to other joints, such as the hips or knees.
HLA-B27 and Ankylosing Spondylitis
One gene, HLA-B27, is strongly associated with a big family of rheumatic diseases called spondyloarthropathies. It includes: Axial spondyloarthritis.
Don't do movements that cause pain
Carefully consider high-impact exercises, such as running, or jarring and twisting sports, such as tennis, squash, and racquetball. These could increase pain in the spine, hips, and knees.
Sleep on your back to ease ankylosing spondylitis symptoms
Many people find relief from their ankylosing spondylitis symptoms by sleeping on their back. I tell my patients that the key to sleeping in this position is to maintain the natural curvature of their spine.
Nonsteroidal anti-inflammatory drugs (NSAIDs) — such as naproxen sodium (Aleve) and ibuprofen (Advil, Motrin IB, others) — are the medicines health care providers most commonly use to treat axial spondyloarthritis and nonradiographic axial spondyloarthritis.
"Fatigue from inflammation in ankylosing spondylitis can feel like you have the flu. You can ache all over," says Rochelle Rosian, MD, the director of regional rheumatology at the Cleveland Clinic in Ohio. “That's because inflammation affects your whole body, not just your joints.”
X-rays and MRIs are the two most common imaging tests used to help diagnose ankylosing spondylitis, but they each have their limitations and challenges. European medical guidelines call for conventional X-rays of the sacroiliac joints as the first imaging method to help diagnose AS.
It is a rare disease, there is no cure, and you will end up in a wheelchair.
At this time, no single test diagnoses ankylosing spondylitis. Your doctor may order a blood test to check for the HLA-B27 gene, which is present in most people with the disease. You may have the HLA-B27 gene and never develop ankylosing spondylitis, but it can give doctors more information when making a diagnosis.
This progression can take 10 years or more to happen. And not everyone with nr-axSpA will progress to AS. Another method of measuring progression is looking at inflammatory blood markers. Many people with active inflammatory axSpA have more signs of inflammation in their blood.
More than 90% of people with ankylosing spondylitis have a particular genetic marker called HLA-B27, which can be found on their white blood cells. This marker does not appear to be the only cause, however, as 80% of people with this genetic marker never develop an inflammatory disease.
The hallmark feature of ankylosing spondylitis is the involvement of the sacroiliac (SI) joints during the progression of the disease. The SI joints are located at the base of the spine, where the spine joins the pelvis. More information on ankylosis and iritis can be found in the Complications section.
Ankylosing spondylitis is caused by Klebsiella.
Is multiple sclerosis related to ankylosing spondylitis? No. Multiple sclerosis and ankylosing spondylitis are not related. The only common ground they share is that both are autoimmune diseases.
"B27 disease" is a new autoimmune disease that afflicts millions of people throughout the world. "B27 disease" occurs in individuals who have ankylosing spondylitis (AS) or preankylosing spondylitis and/or uveitis and are also positive for HLA-B27.
Some foods can trigger ankylosing spondylitis, so it's important to avoid certain foods to prevent inflammation. These include foods that are high in fat, salt, and sugar; processed foods, dairy products, alcohol, caffeine, artificial sweeteners, and others.