“The best time to take a multivitamin is with food so any fat can help with absorption. You can also drink a water-based beverage to wash it all down,” notes Dr. Perez-Gallardo. “But the drawback is that your body won't absorb the water-soluble vitamins as well as fat-soluble ones.”
Take your multivitamin with food.
Because certain vitamins are helpful only when taken with food, it's best to take your multivitamin with a meal or snack. Vitamins A, D, E and K are fat-soluble, meaning your body can absorb them only when they're digested with fat.
Your body absorbs some of its vitamins better with food, so you may want to take it with a meal or a snack. You'll also avoid the upset stomach that you can get when you take it on an empty stomach. Not a breakfast person? Have it with lunch or even dinner.
Combining multiple supplements or taking higher-than-recommended doses can increase the risk that they can cause harm, said Kitchin. "You really can't get toxic doses of nutrients through food, but you can absolutely get toxic doses through supplements," Kitchin said.
The short and simple answer is: Yes! Vitamins C and D are commonly found together in multivitamins. They have complementary effects, which means that taking them together can better support your health. They're particularly beneficial to the immune system.
Combining supplements will not normally interfere with the way they work and in some cases may be beneficial, for example vitamin C helps iron absorption. However, certain supplements may interact with each other.
Therefore, conditions that affect the gut and digestion, like celiac disease, chronic pancreatitis, Crohn's disease, and cystic fibrosis, can reduce vitamin D absorption.
Interactions between your drugs. No interactions were found between Vitamin B12 and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
“Digestion slows down during sleep, so taking your nutrient supplement late at night would not be associated with an efficient absorption.” Neil Levin, a clinical nutritionist at NOW Foods, agrees that morning is best for multivitamins and any B vitamins.
Supplementing vitamin B6 may improve sleep quality and duration. A 2019 study also found that taking a supplement of magnesium, melatonin, and vitamin B complex for 3 months improved sleep and helped treat insomnia.
Try to avoid taking your vitamins with coffee or tea
So, wait an hour after your morning brew to take supplements. Caffeine-free herbal tea, on the other hand, contains fewer tannins than regular tea. This beverage may actually increase the absorption of certain minerals such as iron.
Since vitamin D is fat soluble, it's best not to take it on an empty stomach. For maximum absorption, take it with a substantial meal, and preferably one that includes fat-containing foods like nuts, seeds, and eggs.
With a meal: Vitamin D is a fat-soluble vitamin. This means it does not dissolve in water. Your body absorbs Vitamin D better when it is consumed with healthy fats, such as avocados, nuts, eggs, and seeds. Taking your supplement with breakfast or lunch is recommended, or you can even take it with an afternoon snack.
According to health experts at Click Pharmacy, as a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
Vitamin C (ascorbic acid) supplements.
Taking vitamin B-12 with vitamin C might reduce the available amount of vitamin B-12 in your body. To avoid this interaction, take vitamin C two or more hours after taking a vitamin B-12 supplement.
Magnesium assists in the activation of vitamin D, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys.
The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.
Vitamin D can indeed cause hair loss, but it's rare. Although the precise role of vitamin D in hair growth isn't well understood, research shows that vitamin D receptors play an important role in the anagen phase of the hair follicle cycle — the phase in which new hairs grow from the follicle to their full length.
Magnesium assists your body in regulating zinc levels, but high intakes of zinc can be detrimental to magnesium absorption – only abnormally high doses (around 142 mg of zinc per day) will reduce magnesium absorption.
But routinely getting an overload of vitamins and minerals can hurt you. Too much vitamin C or zinc could cause nausea, diarrhea, and stomach cramps. Too much selenium could lead to hair loss, gastrointestinal upset, fatigue, and mild nerve damage.
Can you take vitamin D and magnesium together? Yes. In fact, it's probably best to take both together. Because so many people have low magnesium levels, vitamin D supplements on their own aren't very helpful for a large portion of the population.