An abnormally high vitamin B-12 status is anything over 900 pg/mL. This result may suggest liver or kidney problems, diabetes, or certain forms of leukemia.
Ultimately, this study found that elevated B12 levels may be an important biomarker for cancer. The hypothesis was corroborated in a separate 2020 study, which showed that unexplained high vitamin B12 levels might be linked with the development of “solid” cancers (those with tumors, as in breast cancer) [6].
Chronic myelogenous leukemia (CML)
Vitamin B12 plays a role in the development of red blood cells. A deficiency of this vitamin can cause significant changes in the bone marrow, which can mimic acute leukemia, a serious condition. So, while vitamin B12 deficiency can give rise to a similar clinical picture as leukemia, it does not cause the condition.
Vitamin B12 serum concentrations have been investigated in various types Of leukemia. 2. The concentration in chronic myeloid leukemia is approximately 15 times normal. In chronic lymphatic leukemia it is normal.
An abnormally high vitamin B-12 status is anything over 900 pg/mL. This result may suggest liver or kidney problems, diabetes, or certain forms of leukemia.
What Abnormal Results Mean. Values of less than 160 pg/mL (118 pmol/L) are a possible sign of a vitamin B12 deficiency. People with this deficiency are likely to have or develop symptoms. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms.
Vitamin B12 deficiency is a treatable condition that happens if you are not consuming enough vitamin B12 in your diet or if your body is not absorbing it properly. Vitamin B12 deficiency can cause physical, neurological and psychological symptoms. It can be treated with vitamin B12 medications.
Although it's uncommon, vitamin B12 or folate deficiency (with or without anaemia) can lead to complications, particularly if you've been deficient in vitamin B12 or folate for some time. Potential complications can include: problems with the nervous system. temporary infertility.
There are other ways that lymphoma and its treatment can cause anaemia, including: A shortage of the vitamins and minerals your body uses to make red blood cells (especially iron, folic acid or vitamin B12). This might happen if you are not eating well.
Vitamin B12–deficiency anemia, also known as cobalamin deficiency, is a condition that develops when your body can't make enough healthy red blood cells because it doesn't have enough vitamin B12.
What does it mean if your Vitamin B12 result is too high? The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12. It could also be possibly from your diet if high in animal products such as meat, eggs, and shellfish.
Elevated Vitamin B12 Levels in Autoimmune Lymphoproliferative Syndrome Attributable to Elevated Haptocorrin in Lymphocytes.
Muscle cramps and weakness
If a B12 deficiency is preventing the body from producing enough red blood cells to get oxygen to muscle tissues, you may experience associated symptoms, like sporadic muscle cramps or weakness [3].
Elevated serum B12 levels may also be associated with a functional deficiency of the vitamin. Functional deficiency has been described despite high B12 concentrations and is due to a failure of cellular uptake or intracellular processing, trafficking or utilization.
Some signs of leukemia, like night sweats, fever, fatigue and achiness, resemble flu-like symptoms. Unlike symptoms of the flu, which generally subside as patients get better, leukemia symptoms generally last longer than two weeks, and may include sudden weight loss, bone and joint pain and easy bleeding or bruising.
When is a patient tested for leukemia? "A patient may be tested for leukemia if he or she has unexplained weight loss, night sweats or fatigue, or if he or she bruises or bleeds easily," Dr. Siddon says. "Sometimes routine blood work shows an unexplained elevated number of white blood cells."
Stage I: The patient has lymphocytosis and enlarged lymph nodes. The patient does not have an enlarged liver or spleen, anemia, or low levels of platelets. Stage II: The patient has lymphocytosis and an enlarged spleen and/or liver and may or may not have swollen lymph nodes.
Generally 120-680 pmol/L.
A serum vitamin B12 level between 200 pg/mL and 900 pg/mL is considered normal, but a threshold of 300 to 350 pg/mL is recognized as a marker for a desirable status in the elderly. The laboratory diagnosis is usually based on low serum vitamin B12 levels or elevated serum methylmalonic acid and homocysteine levels.
Vitamin B12 deficiency is common among the elderly. Elderly people are particularly at risk of vitamin B12 deficiency because of the high prevalence of atrophic gastritis-associated food-cobalamin (vitamin B12) malabsorption, and the increasing prevalence of pernicious anaemia with advancing age.
Many cases of leukemia across the globe may be caused by vitamin D deficiency as a result of low sunlight exposure.