Vitamin B12 is needed to form red blood cells and DNA. It is also a key player in the function and development of brain and nerve cells. Vitamin B12 binds to the protein in the foods we eat.
A: Vitamin B-12 is a water-soluble vitamin. Excess amounts of it (no matter how much you take) typically are just cleared by the kidney, so high levels of B-12 can occur if the kidneys aren't working properly. B-12 is stored by the liver, so any liver damage that causes cells to die can increase blood B-12 levels.
Vitamin B12 is an essential nutrient that helps the body create DNA, nourishes the brain and nervous system, and assists with the formation of healthy red blood cells.
The common forms of vitamin B include vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B6 (pyridoxine) and B12 (cyanocobalamin). Except for niacin (when given in high doses), there is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.
How does vitamin B12 intake influence kidney function? B12, in general, is needed by all body organs for functioning since it controls the nervous system. B12 may not be a highly influencing factor for kidney function, but it is undoubtedly important when treating kidney diseases.
All types of anaemia, regardless of the cause, can lead to heart and lung complications as the heart struggles to pump oxygen to the vital organs. Adults with severe anaemia are at risk of developing: an abnormally fast heartbeat (tachycardia)
Autoimmune dysfunction and chronic vitamin B12 deficiency might lead to decreased hepatic detoxification and damage repair, and to progression of chronic liver disease, like liver cirrhosis.
Conclusion: The present study indicates that increased serum vitamin B12 concentrations may play a role in NAFLD risk. NAFLD also has a causal impact on elevated vitamin B12 concentrations in the circulation.
Vitamin B12 for Fatty Liver Disease
The researchers also found that supplementing with vitamin B12 and folic acid increased levels of syntaxin 17 in the liver, restoring its role of digesting fat and protecting against inflammation.
The findings from this research suggest that vitamin B12 and folic acid may have the potential to positively impact liver health, specifically when it comes to individuals with fatty liver disease. These particular nutrients, in the form of supplements, may even hold the possibility of reversing fatty liver disease.
Key points about vitamin B12 deficiency anemia
Without enough red blood cells, your tissues and organs don't get enough oxygen. Without enough oxygen, your body can't work as well. Symptoms include weak muscles, numbness, trouble walking, nausea, weight loss, irritability, fatigue, and increased heart rate.
Your body absorbs only as much as it needs, and any excess passes through your urine. High doses of vitamin B-12, such as those used to treat a deficiency, might cause: Headache. Nausea and vomiting.
This new study hints that two nutrients, folate and vitamin B12, might be especially beneficial to help support liver health and potentially reverse nonalcoholic fatty liver disease. Much more research is needed to confirm these findings.
The Framingham Heart Study found that elevated B12 at baseline was associated with two different markers of impaired kidney function: albuminuria and reduced glomerular filtration.
If you have any of the following health problems, consult your doctor or pharmacist before using this medication: a certain eye disease (Leber's optic neuropathy), a certain blood disorder (polycythemia vera), gout, iron or folic acid deficiency anemia, low potassium blood levels (hypokalemia).
The two exceptions to the lack of harm to the liver by higher doses of vitamins are vitamin A and niacin, both of which can cause distinctive forms of liver injury when taken in high doses.
Exercise and healthy dietary supplements, including micronutrients, are promising methods to manage NAFLD. Vitamins A, B3, B12, D, and E can serve as targets for NAFLD therapy, although some are linked to adverse effects. Vitamin D status and obesity have an inverse relationship.
Our results demonstrate a substantial positive relationship between vitamin B12 and hepatic enzyme serum levels. This correlation may be interpreted as meaning that, with increasing hepatocellular damage, as indicated by elevated hepatic enzymes, serum vitamin B12 also tends to be higher.
Vitamin B12 is stored in excess in the liver, decreasing the likelihood of deficiency. However, in cases in which vitamin B12 cannot be absorbed, for example, due to dietary insufficiency, malabsorption, or lack of intrinsic factor, hepatic stores are depleted, and deficiency ensues.
The current study showed that supplementation with vitamin B12 (1000 µg cyanocobalamin per day) for 12 weeks among patients with NAFLD improved serum levels of homocysteine. Also, the fasting blood glucose and serum levels of MDA were significantly improved in the trial group who received vitamin B12.
Medical research on milk thistle and liver health has led to mixed results. Studies show that silymarin may help ease inflammation and promote cell repair. This may help ease symptoms from liver diseases like jaundice, cirrhosis, liver cancer, and fatty liver disease.