Summary: As many as one in two patients stop taking statins, reduce the dose or take them irregularly because they believe the cholesterol-lowering drugs cause muscle pain and other side-effects.
If you've made lifestyle changes through diet and exercise that have lowered your cholesterol levels, you may not need to continue taking a statin. These changes can help reduce your risk of heart attack, stroke, or blocked arteries while allowing you to take one less medication.
Statin use increased from April 2011 to December 2016 (65–75 years: 38.6% to 43.3%; ≥76 years: 26.5% to 30.0%), as did high intensity statin use (65–75 years: 4.8% to 9.5%; ≥76 years: 2.3% to 4.5%).
Statins can stabilize cholesterol plaque already attached to artery walls, making it less likely to get worse or rupture, causing a heart attack or stroke. "Statins also help remove cholesterol from you blood by causing the liver to express more LDL cholesterol receptors that take cholesterol out of your blood," Dr.
Because many factors are involved, your cholesterol numbers may be considered normal and yet you may still be found to be at an elevated risk for heart problems. As a result, statin medications are now used to lower the risk of heart disease and heart events in most anyone found to be at high risk.
As with all drugs, statins may have adverse effects; these include musculoskeletal symptoms, increased risk of diabetes, and higher rates of hemorrhagic stroke.
Although there are some potential side effects long-term for statins, in most cases, if your doctor has identified you as having high cholesterol and needing a statin, the benefits greatly outweigh the risks. Muscle aches are among the most common complaints.
Do not start a statin in patients ages ≥ 75 years who do not have known vascular disease or type 2 diabetes; start or continue a statin in all patients ages 75 to 84 with type 2 diabetes to prevent cardiovascular events and mortality; and start or continue a statin in patients ages > 75 years who have known vascular ...
Statins should not be taken if you have liver disease or if blood tests suggest that your liver may not be working properly. This is because statins can affect your liver, and this is more likely to cause serious problems if you already have a damaged liver.
Statin drugs have been shown to reduce the risk of cardiovascular disease (CVD) in young and middle-aged adults. With older adults (those 75 and over), the benefits are less clear. But a recent study published in the European Heart Journal suggests that there is in fact a benefit to statin use in this older population.
The average age at which patients started on statins was 62; nearly half (48.5%) of them were women. All had started treatment between 1990 and 2016. Any reduction in cholesterol below 40 per cent after two years of statin treatment was deemed to be a 'suboptimal' response.
Elevated cholesterol levels are not uncommon in the elderly (61% of women aged between 65 and 74 have total cholesterol levels over 6.2 mmol/L [240 mg/dL]).
Statins are effective, accessible, and affordable. However, well-known side effects like muscle pain keep some people from taking them.
If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.
“So everyone over 75 is at high risk.” On the other hand, older patients are more likely to be on multiple medications that can interact with statins. And there's some evidence that this age group may be more prone to statin side effects, such as muscle pain, an increased risk of diabetes, and liver problems.
The American Heart Association guidelines say older people should take statins if they have known cardiovascular disease, low-density lipoprotein (LDL) cholesterol of 190 or over, or are at high risk.
"For years, there was this controversy whether or not older people will benefit from statins, but the controversy was mostly based on the fact that clinical trials did not include many older people," says Dr. Lopez-Jimenez. He says there's a growing body of research that shows statins benefit this age group.
Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake.
Providers prescribe statins for people who: Have high cholesterol (LDL above 190 mg/dL) that exercise and diet changes couldn't reduce. Had a stroke, heart attack or peripheral artery disease. Have diabetes and an LDL of at least 70 mg/dL and are 40 to 75 years old.
In the largest statin survey ever conducted, the National Lipid Association observed that roughly 30% of statin patients reported experiencing muscle pain and weakness and 57% of surveyed patients reported stopping the drug due to side effects[37].
High cholesterol levels are considered: too high: between 5 and 6.4mmol/l. very high: between 6.5 and 7.8mmol/l. extremely high: above 7.8mmol/l.
Bempedoic Acid: A Statin Alternative to Reduce Cholesterol
All of the patients had a history of or were at high risk for getting heart disease.