Metformin and berberine share many features in actions despite different structure and both could be excellent drugs in treating T2DM, obesity, cardiac diseases, tumour, as well as inflammation.
Inositol is superior to metformin in how the body uses insulin. While metformin is a very common treatment for PCOS, it is not the only treatment option. Another insulin sensitizing agent class is inositol. Research has shown that inositol improves the way the body uses insulin to help burn sugar.
The source of metformin is galegine, a natural product produced by the plant Galega officinalis [53,54].
An effective substitute for Metformin is a compound known as berberine or berberine hydrochloride, which is obtained from many plant species, including goldenseal, barberry, Oregon grape, and turmeric.
PhenQ produces excellent weight loss results and is arguably the best Metformin alternative to obtain over the counter or online. For those looking to lose weight without using prescription medication, PhenQ is a premium supplement with a long history of success.
The results: Myo + DCI showed significantly better results in weight reduction, ovulation, and pregnancy rates (46.7% vs. 11.2%) than metformin.
Inositol shows promise in the treatment of metabolic disorders and polycystic ovary syndrome. However, further research is needed to recommend the use of inositol as a treatment. Always talk to your doctor first if you are considering taking inositol to treat a health condition.
and Warnings. When taken by mouth: Berberine is possibly safe for most adults. It's been used safely in doses up to 1.5 grams daily for 6 months. Common side effects include diarrhea, constipation, gas, and upset stomach.
What foods contain berberine? Berberine is found in the roots, leaves, stems, and bark of plants such as barberry, Oregon grape, and tree turmeric. It is uncommon to find these plants at your local supermarket in the United States, which is why berberine is usually taken in supplement form.
As a result, cinnamon seems to be as effective as metformin in increasing the Insulin sensitivity. In line with this study, Maleki et al. showed that HDL and insulin sensitivity were increased by the cinnamon supplementation while LDL, TG, and blood glucose were decreased in patients with PCOS (17).
Making positive lifestyle changes such as eating a well-balanced diet, exercising regularly and getting down to a healthy weight (and maintaining it) are the key to possibly reversing or managing type 2 diabetes.
Liver disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can cause liver damage. Don't use inositol nicotinate if you have liver disease. Sensitivity to niacin: Niacin is released when inositol nicotinate is processed by the body.
Inositol is generally safe to take. However, supplementing inositol at dosages above 12 grams (g) a day may cause mild gastrointestinal symptoms, such as nausea, flatulence, or diarrhea.
Inositol could also help women without polycystic ovary syndrome become pregnant. In addition to women with PCOS, myo-inositol supplements might also benefit women without this condition. One study found that inositol improves the quality of embryos and clinical pregnancy rates in women without PCOS utilizing IVF.
Luckily, there is evidence that inositol canhelp you lose weight in combination with other lifestyle changes such as exercise and diet, and that this combination may work better than exercise and diet alone.
Lower Blood Sugar Levels
A type of inositol, D-chiro-inositol, combined with folic acid also increased insulin sensitivity in people with type 1 diabetes. People treated with inositol and folic acid had lower average blood sugar levels, known as HbA1c, than the people in the control group.
Abstract. Choline and myo-inositol are dietary supplements ingested under the premise that they facilitate the burning of stored fat.
Berberine is a natural plant extract found in the roots, rhizomes, stems, and bark of several plants, including goldenseal, goldthread, Oregon grape, philodendron, tree turmeric, and barberry.
If your diabetes remains hard to manage even after you begin taking metformin, or you cannot tolerate metformin or do not want to take it, that's when a GLP-1RA or SGLT2i might come in. Studies have shown that both medications are safe and effective at lowering blood glucose when compared to a placebo.