When an embryo fails to implant, there can only be two logical reasons: the embryo is not good enough (genetically abnormal), or the endometrium is not “receptive” (doesn't allow the embryo to implant) enough.
Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors.
Embryo transfer is usually cancelled due to a lack of embryos, due to lack of fertilization or arrested development. Another cause is that the endometrium is not in the ideal condition for implantation to occur.
Emergency contraceptives, like Plan B, are drugs and products used to prevent pregnancy or prevent the implantation of a new pregnancy.
Progesterone is what stabilizes the uterine lining and makes it “sticky” enough for an embryo to attach. Without enough progesterone, it can be more difficult for an embryo to successfully implant. Progesterone stabilizes the uterine lining and makes it “sticky” enough for an embryo to attach.
Think lots of fresh fruits, vegetables, good quality proteins, nuts and seeds, healthy fats and whole grains. The key here is blood sugar control to support implantation and early embryo development, so limit the junk and focus on real, nutrient-dense food.
Screen for underlying health conditions – Sometimes underlying health conditions can prevent an embryo from implanting. These can include uterine problems, hormonal issues, thyroid problems, diabetes, and many others. Even a prior infection can cause implantation troubles.
Mental stress can lead to an increased endogenous level of epinephrine. Excessive epinephrine level may interfere with the decidual differentiation of human endometrial stromal cells and thus affect embryo implantation.
Early pregnancy loss can be grouped into two different categories based on when the loss happens. Sometimes the embryo just won't implant, which is still a loss for the patient, though not technically considered a miscarriage.
Possibilities may include obesity, the wrong type of ovarian stimulation, poor injection techniques, and too little ovarian stimulation. Being a poor responder often comes as a result of diminished ovarian reserve (DOR), or low functional ovarian reserve.
They then shed their shells and try to attach to the uterine wall, activating placenta-promoting genes. But after about 2 days, the mother's immune system "rejects" the embryos, causing the birth of a litter still at a very immature developmental stage compared with placental mammals.
Of those fertilised eggs, around 15% will be lost before implantation begins. Of those which begin to implant, only about half will implant successfully.
Blastocysts contain chromosomes. If there are chromosomal abnormalities, such as an extra chromosome or a chromosome that's duplicated or deleted, the blastocyst usually won't implant in your endometrium.
Most fertility specialists believe that in more than 95% of IVF failures it is due to arrest of the embryos. Embryonic arrest is quite often due to chromosomal or other genetic abnormalities in those embryos that made them too “weak” to continue normal development and sustained implantation.
Also, about 1% of implanting embryos will split into identical twins. As a result, even when “only” two embryos are transferred, triplet pregnancy can still occur. The risks of low birth weight and prematurity are not to be taken lightly.
Generally, when implantation occurs, you may experience sensitive breasts and mild abdominal cramping. If you haven't experienced these in the weeks after your embryo transfer, it may be indicative that the implantation has failed. Additionally, you may experience vaginal bleeding.
Current studies show that maternal caffeine exposure not only severely disrupts embryo implantation but also disrupts ongoing midterm fetal growth and development, resulting in pregnancy loss, low birth weight, and impaired brain development in offspring on postnatal day 6 (P6) [35–38,55].
It is within this time frame that an embryo has to “attach” to the uterine wall before it can fully implant, which may take several days. Therefore, for the first one to two days, stay home and chill out. Avoid vigorous activities such as heavy lifting, bending or exercise.
During the two-week wait, it's better to err on the side of caution. Avoid having a drink, smoking, or any other activity that could be harmful to a brand new pregnancy. It's fine to continue exercising if you already have a workout routine, but now might not be the time to take up a new, intense form of exercise.
According to the research, sleeping on one's back improves the odds of a successful outcome. It has increased the success rate by 0.014 percent.