Signs and Symptoms Characteristic lesions are located in the periventricular and juxtacortical regions, in addition to the brainstem, cerebellum, spinal cord, and optic nerve.
MS lesions developed preferentially in the supratentorial brain, particularly the frontal lobe and the sublobar region.
But the brain isn't the only area where lesions can develop — MS can also attack the spinal cord. Because finding these lesions involves more elaborate imaging tests, spinal cord lesions in MS are studied less often, and many people with MS aren't aware of the role these lesions may play in the disease process.
Numbness of the face, body, or extremities (arms and legs) is often the first symptom experienced by those eventually diagnosed as having MS.
Most symptoms develop abruptly, within hours or days. These attacks or relapses of MS typically reach their peak within a few days at most and then resolve slowly over the next several days or weeks so that a typical relapse will be symptomatic for about eight weeks from onset to recovery.
Thus, MS lesions themselves cannot be felt. Instead, they may induce symptoms that result from tissue damage to the nervous system. The symptoms and signs of MS can vary depending on the particular location of the lesion.
About 5 percent of people who are confirmed to have MS do not initially have brain lesions evidenced by MRI. However, the longer a person goes without brain or spinal cord lesions on MRI, the more important it becomes to look for other possible diagnoses.
Feeling fatigued is one of the most common and troublesome symptoms of MS. It's often described as an overwhelming sense of exhaustion that means it can be a struggle to carry out even the simplest activities.
Early MS symptoms may include blurred vision, numbness, dizziness, muscle weakness, and coordination issues. MS is progressive and can worsen over time. Eventually, the disease can do damage directly to the nerves, causing permanent disability.
The early signs and symptoms of MS can be the same for women and men. One of the more obvious first signs of MS is a problem with vision, known as optic neuritis. This is often because it's a more concrete symptom as opposed to vaguer neurological symptoms like numbness and tingling.
Diagnosing MS
More than 90% of people with MS have scar tissue that shows up on an MRI scan. A spinal tap can check for abnormalities in the fluid that bathes the brain and spinal cord. Tests to look at electrical activity of nerves can also help with diagnosis.
Can Lesions Heal Once They Appear? “Absolutely,” says Dr. Hua. “It's not specific to MS, but in any process where there's some sort of brain injury, there will always be healing, as well.
An “average” number of lesions on the initial brain MRI is between 10 and 15. However, even a few lesions are considered significant because even this small number of spots allows us to predict a diagnosis of MS and start treatment.
People from regions near the equator, where there is a great deal of bright sunlight, generally have a much lower risk of MS than people from temperate areas such as the U.S. and Canada. Studies have found that people who smoke are more likely to develop MS and have a more aggressive disease course.
People should consider the diagnosis of MS if they have one or more of these symptoms: vision loss in one or both eyes. acute paralysis in the legs or along one side of the body. acute numbness and tingling in a limb.
MS can appear at any age but most commonly manifests between the ages of 20 and 40. It affects women two to three times as often as men. Almost one million people in the United States have MS, making it one of the most common causes of neurological disability among young adults in North America.
It's most commonly diagnosed in people in their 20s, 30s and 40s although it can develop at any age. It's about 2 to 3 times more common in women than men. MS is one of the most common causes of disability in younger adults.
Although more people are being diagnosed with MS today than in the past, the reasons for this are not clear. Likely contributors include greater awareness of the disease, better access to medical care and improved diagnostic capabilities. There is no definitive evidence that the rate of MS is generally on the increase.
Devic's disease/NMO most often affects only the optic nerve and spinal cord at first. With MS, changes in memory, reasoning, problem solving and depression are also common. Vision loss with MS usually affects one eye at a time, but Devic's disease/NMO may affect both eyes at the same time.
The average risk of developing MS in the United States is roughly 3.5 in 1,000, or less than half of one percent. For first-degree relatives (such as a child or sibling), the risk increases to three or four percent.
Not Uncommon
“MS is diagnosed most commonly in the ages between 20 and 50. It can occur in children and teens, and those older than 50,” said Smith. “But it can go unrecognized for years.”
The term benign MS is sometimes used to describe a version of relapsing remitting MS with very mild or no attacks separated by long periods with no symptoms. 'Benign' means 'something doesn't cause any harm'.
Can I have multiple sclerosis for years and not know it? Yes. MS can go undetected for years. Research has suggested that many patients experience MS-related symptoms and signs several years before receiving a definite diagnosis of the disease.