Despite this, there was no significant difference between the two drugs in how well they decreased the volume of atherosclerotic buildup in the arteries. Both Crestor and Lipitor are generally well tolerated with a similar rate of side effects.
These statins, including atorvastatin (Lipitor®), simvastatin (Zocor®) and fluvastatin (Lescol®), are more likely to cause muscle aches. The hydrophilic statins, including rosuvastatin (Crestor®) and pravastatin (Pravachol®), have to be actively transported and cause fewer muscle aches.
Side effects of Lipitor and Crestor that are similar include constipation, diarrhea, nausea, heartburn/indigestion, headache, and muscle aches or pains. Side effects of Lipitor that are different from Crestor include fatigue or gas.
Conditions treated: Lipitor and Crestor are both used to treat high cholesterol and reduce certain heart risks. However, Crestor is also used to slow the buildup of plaque in the arteries.
Both Lipitor and Crestor are excellent medications to help improve high cholesterol and to decrease your risk of heart attacks and strokes. In studies, Crestor was more effective at lowering total cholesterol levels and raising HDL levels (Jones, 2003).
Public Citizen petitioned the FDA in 2004 and 2005 to recall Crestor. The advocacy organization's health research group documented cases of patients who developed rhabdomyolysis after taking the drug. Rhabdomyolysis is a severe form of muscle damage that can lead to permanent kidney damage, coma and sometimes death.
It's thought that simvastatin (Zocor) may be more likely to cause muscle pain as a side effect than other statins when it's taken at high doses. Change your dose. Lowering your dose may reduce some of your side effects, but it may also reduce some of the cholesterol-lowering benefits your medicine has.
Is muscle pain a side effect of all statins? Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so.
While pravastatin and fluvastatin may be associated with the lowest incidence of myalgia, the LDL-lowering effect is low compared to other statins.
A new study has shown that another drug called Nexletol (bempedoic acid) can help people lower their cholesterol and prevent heart disease without causing the muscle pain that can come with taking statins.
Statins. Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes.
The most common side effects of Crestor include headaches, abdominal pain and nausea. Serious side effects of Crestor may include muscle pain, tenderness and weakness, or myopathy. Crestor may increase the risk of diabetes, liver damage and hemorrhagic stroke.
Of all statins, simvastatin and atorvastatin are responsible for most reported incidents of liver damage, but this is likely just due to the fact that they are prescribed the most. The Spanish Hepatotoxicity Registry identified 858 cases of drug-induce liver injury.
Statin use has been linked to a higher risk of developing diabetes because the medication can fuel mild glucose elevations in predisposed individuals — an effect that can often be countervailed by exercise and losing as little as a few pounds.
Conclusions— As a class, adverse events associated with statin therapy are not common. Statins are not associated with cancer risk but do result in a higher odds of diabetes mellitus. Among individual statins, simvastatin and pravastatin seem safer and more tolerable than other statins.
Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population.
In relation to renal function, atorvastatin was the safest statin as it resulted in the least number of patients at the end of 2 years of treatment with the new onset of microalbuminuria (10.9%) followed by rosuvastatin (14.3%) and then pravastatin (26.6%).
Call your doctor right away if you have unexplained muscle pain or weakness, especially with fever; have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR; feel unusually tired; or have loss of appetite, upper belly pain, dark urine, or yellowing of skin or eyes.
Statins can stabilize cholesterol plaque already attached to artery walls, making it less likely to get worse or rupture, causing a heart attack or stroke. "Statins also help remove cholesterol from you blood by causing the liver to express more LDL cholesterol receptors that take cholesterol out of your blood," Dr.