Hashirama Senju, aka the First Hokage, was the only one who could ever beat Madara Uchiha in life.
During his lifetime there was only one character who could defeat Madara and that happened to be Hashirama. He was so powerful that later in life Madara went on to implant Hashirama's cells in his body to gain more powers which led to his Rinnegan awakening.
1 Naruto Uzumaki
The strongest enemy that Madara fought in the story was, undoubtedly, Naruto Uzumaki. Like Sasuke, Naruto was left in a near-death state by Madara Uchiha.
No Boruto cannot beat Madara alone… Madara is far more powerful than Boruto…..
There isn't a contest. Madara wins. While Saitama is strong, it's unlikely that his strength would be enough to harm Madara. However, even if it was, he has to actually land the punch, and Madara could easily prevent Saitama from getting in punching range and can simply dodge out of the way of any blow Saitama throws.
4) Madara Uchiha
So along with his already overpowered versions of several sharingan attacks, he also had access to Infinite Tsukiyomi. This technique, in addition to any other genjutsu attack, may seem to be the go-to move to defeat Gojo.
The short answer is Goku wins , in practically every scenario and against all the characters in Naruto verse .
1) Madara Uchiha
As a child, Madara was able to awaken his Sharingan with one Tomoe in each eye. His mastery of the Sharingan and jutsu capabilities makes him far stronger than Kakashi.
Despite the power of the Rinnegan as well as the access to five different bodies, Nagato, aka Pain, would be no match for Madara Uchiha. Between Madara's own Rinnegan, his Mangekyo Sharingan, and the Susano'o, Madara has powers that Pain never quite reached.
Itachi would have surpassed Madara Uchiha if things were different for him. He learned every powerful Jutsu at a very young age and had a whole life to hone his skills and strength. However, he died too soon and his true potential never saw the light of day.
Madara then went on to become the Ten-Tails Jinchuriki and reached godly levels of power, only to be struck down by his own ally, Zetsu. After Kaguya's defeat, Madara Uchiha's body was released, and he finally passed away next to his friend, Hashirama Senju.
Madara Uchiha
Sasuke aside, Madara is easily the strongest Uchiha in the land. His boldness knows no limits after we witnessed him directly challenge the God of the Shinobi in order to compare himself directly to the best. After obtaining the power of Rinnegan, he went on to control the Ten-Tailed beast's Jinchuriki.
Madara was much stronger than Obito to begin with, and the fact that his version of the Ten-tails was perfect made him even stronger. When compared to Madara, Obito stands absolutely no chance.
7 Weakness: Madara Is Vulnerable To Taijutsu
After mastering the Ten-Tails, Madara became incredibly resilient to all forms of ninjutsu and genjutsu, with the exception of Sage Mode. However, he was still vulnerable to the physical force of taijutsu, providing a weakness that Might Guy was more than happy to exploit.
Minato's son, Naruto Uzumaki is the guy who stood in Pain's path and defeated him during the Pain arc of the Naruto series.
It is easy to see that Sasuke supplants Madara in every category except for chakra reserves as the latter was the jinchuriki of the Ten-Tails. However, Sasuke is far ahead in all the other categories. Consequently, Sasuke is undoubtedly the strongest Uchiha in Naruto.
10 Could: Itachi Uchiha
Itachi was able to fight against Naruto Uzumaki in his Nine-Tails Chakra Mode, something that Pain could never do. He was also able to incapacitate Nagato Uzumaki, and it is quite easy to see that he could definitely have taken on and defeated Pain in combat.
9 CAN'T DEFEAT: Madara Uchiha
Madara has the ability to bring down meteors and can control the Kyubi with his Sharingan. He nearly killed all of the five Kage by himself. Simply put, a man of his caliber could not be defeated by the likes of Venom.
Madara was powerful enough to defeat the entire shinobi alliance by himself and even defeat the 9 Tailed Beasts. For him, defeating the Akatsuki is nothing more than child's play.
Although the two have never fought, the fact that Tsunade struggled against Madara Uchiha and Sasuke demolished a stronger version of him is enough to point out that he's much stronger.
Itachi Uchiha is the single most powerful character in the Naruto Universe. Masashi Kishimoto named himself Itachi Uchiha. He unlocked his power at a very early age, for example, unlocking his Sharingan at a very early age.
With the Rinnegan, Madara can use the Human Path to rip out Luffy's soul or trap him inside of a worldwide illusion. As Juubi Madara, he can use the Truth Seeking Orbs, which destroys what they touch on a molecular level, making it the perfect weapon to destroy Luffy's rubber body.
MS, EMS, Edo Tensei, Rinnegan and Jinchûriki Madara will win. Luffy simply isn't is his league. EMS or Edo Madara already are even stronger than Kaidô. He has power, experience, intelligence and an insane amount of skills.
Unfortunately no version of Madara (yes, even Sage.) can come close to Vegeta. Vegeta was stated multiple times to be able to destroy the planet using his Garriku-Ho (Galick Gun). Madara, using his Susano'o, is able to casually destroy mountains.