Shibai Otsutsuki is, by far, the strongest character to ever appear in the story and, for him, dealing with someone as strong as Naruto wouldn't be an issue at all. Even if Naruto had not lost Kurama, his powers would still be inferior to Shibai Otsutsuki.
Hashirama Senju, aka the First Hokage, was the only one who could ever beat Madara Uchiha in life.
He is dubbed by most to be the strongest shinobi in history. Sasuke himself admitted this fact. In the end, while Sasuke may not be able to beat Naruto, even with his perceived weakened state in Boruto, the two did become friends again. A combination of powers that are said to be able to destroy the entire world.
It is easy to see that Sasuke supplants Madara in every category except for chakra reserves as the latter was the jinchuriki of the Ten-Tails. However, Sasuke is far ahead in all the other categories. Consequently, Sasuke is undoubtedly the strongest Uchiha in Naruto.
It's safe to assume that Naruto surpassed Kakashi during the Pain arc. He was able to defeat Pain and later he was able to use Sage mode as well. His ability to link up with Kurama and his vast chakra reserve make him an incredibly powerful shinobi.
Madara Uchiha is among the most powerful shinobi to have ever lived, and his power only increased when he attained the power of the Sage of the Six Paths. He was able to fend off both Naruto Uzumaki and Sasuke Uchiha for a time in this form, and Kakashi Hatake would likely be unable to subdue Madara on his own.
Naruto: 10 Powers That Make Kaguya Otsutsuki An Absolute God - IMDb. In the renowned series Naruto created by Masashi Kishimoto, Kaguya Otsutsuki is a character who can be considered to be the main catalyst triggering the various events and conflicts that take place in both the manga and anime.
1) Kaguya Otsutsuki
As an Otsutsuki member, Kaguya is the strongest character in the Narutoverse. However, after consuming the entire Chakra fruit for herself from the God tree, she attained godly feats, making her an unstoppable force in Naruto.
Boruto does not have a powerful tailed beast inside of him. This is a source of power unique to the jinchuriki and Boruto is not one. Without Boruto having that power, Naruto can remain stronger than his son.
Thanks to his Six Paths powers, Naruto is above the level of almost every other character in the series. Itachi, while powerful, isn't even a match for Naruto in his Six Paths Sage Mode, who could fight against the likes of Kaguya Otsutsuki and Momoshiki Otsutsuki.
Although the two have never fought, the fact that Tsunade struggled against Madara Uchiha and Sasuke demolished a stronger version of him is enough to point out that he's much stronger.
But Jiraiya not only fought Pain alone in his territory but almost defeated him as well. However, in front of Itachi's Tsukuyomi and Amaterasu, his strength might not be enough. As a result, Jiraiya is a Naruto character who can never defeat Itachi.
However, if the Boruto two characters went up against each other, Kakashi would win despite losing his Sharingan. Kakashi losing his Sharingan means he cannot copy the ninjutsu that the enemy performs.
Naruto and Sasuke are arguably the most powerful characters by the end of the Naruto Shippuden anime, so it goes without saying that Might Guy would stand no chance against Naruto in his Sage of Six Paths mode, or against Sasuke using his Rinnegan.
11 CAN'T DEFEAT: Kakashi Hatake
Furthermore, Sasuke was able to obtain the Rinnegan Eye and the Eternal Mangekyo, giving him another edge against Kakashi. While Kakashi is a brilliant tactician and generally a powerful warrior, he just wouldn't be able to measure up to Sasuke Uchiha as he is now.
While there's no denying that Itachi is powerful, Madara is simply stronger, whichever way you look at it. With the powers of the 10 Tails and the Six Paths at his disposal, Madara is miles ahead of Itachi, and there's no way the latter can even put up a fight.
The short answer to whether the Uzumaki clan is stronger than the Uchihas would be 'yes. ' However, there is a lot to take away from the fights of both legendary clans, since the original story did not touch upon this particular subject.
In conclusion, Obito Uchiha would defeat Itachi Uchiha when comparing the two characters in their strongest forms. Obito has one of the strongest, if not the strongest, Sage Mode in the series and has enough chakra reserve to beat Itachi.
Naruto beat Pain in the series, and this was canon. However, despite entering Sage Mode, Pain was able to drive him to a corner. Towards the end of the series, Naruto did receive powers from Hagoromo, which put him on a whole new level.