Garou is arguably the most powerful villain Saitama has ever faced, being the first villain to match Saitama's full power and give him a genuine fight. Their battle in the manga marked the first time Saitama fought an opponent with one-hundred percent of his power and still unable to one-punch him.
Lord Boros is the leader of the Dark Matter Thieves and is arguably the series' strongest villain to date. Much like Saitama, Boros suffers an existential crisis after realizing that he has become too strong. Boros is credited with being the strongest opponent Saitama has ever fought.
There's literally nothing Saitama can do against Ryuk, the god of death. As he cannot touch him, he cannot use his signature move, Serious Punch, against Ryuk. Once Saitama's name is written in the notebook, he is gone.
Blast is the overarching protagonist of One Punch Man. He is the S-Class Rank 1 hero of the Hero Association. Other than Saitama he is the strongest known hero of the Hero Association.
Mugen is known to run into trouble due to personality. He doesn't really care about the other person unless they start bothering him in which case he simply beats them up. Saitama will most likely not appreciate being around Mugen and he will definitely try to get away from Mugen as quickly as he can.
1 Genos: The Closest Person To Saitama Is His Apprentice
Saitama first met Genos after he saved the cyborg from trying to self-destruct after being defeated by a monster, Mosquito Girl.
He had almost completed his meal, and Fubuki took her seat next to him. The Caped Baldy ordered some fries for her, leaving Fubuki surprised that he was making a kind gesture towards her. The fanbase thought Fubuki had romantic feelings towards Saitama due to this interaction.
Blue is a teenager of roughly average height and muscular build with light hair that falls over his face in bangs. His eyes have multicolored irises, being light near the center but dark towards the outside, resembling his father Blast.
The big reveal is that when Saitama finally meets him, he will put two and two together and find out that Blast is his dad. Yes, he is supposed to be an elusive character, but especially with the other stuff we know about him, this just makes sense.
However, Garou proves too powerful for Blast, and he uses Gravity Fission Nuclear Fission attack to dominate the S-class hero. Garou now realizes that Saitama wasn't fighting at his full potential. So, to bring out the baldy's real strength, Garou kills Genos by taking out his core.
Saitama takes on God in One-Punch Man: The Fight of Gods, a passion project for one fan artist. In an effort to save the universe, Saitama punches God in the face in the non-canonical One-Punch Man: The Fight of Gods, a fan-made comic based on the popular anime, manga and webcomic.
One of Saitama's most prominent weaknesses is his lack of combat training. He was able to achieve his god-like strength through a strict work-out regimen, comprising 100 sit-ups, squats, and push-ups, followed by a 10-kilometer run.
Given his monstrous strength, one would assume that this character is an S-class hero, but the truth is that he is only a B-class hero in the anime when he defeated Sea King during the first season of the One Punch Man.
God is the overarching antagonist of the Monster Association arc in the manga One Punch Man and possibly the entire series. It is a mysterious entity that desires the eradication of all humanity. However, it chooses to remain hidden for the time being and instead grants powers to others who share its thoughts.
The title protagonist, Saitama (サイタマ), is a bald-headed 25-year-old man who is bored of fighting because he is able to effortlessly defeat enemies with a single punch.
The origin of Saitama's immeasurable power remains mysterious and unclear. Although he tells everyone he got his incredible power through mere physical training, no one believes him at all.
After receiving what seem-to-be a fraction of power from "God", Garou mutated, gained various powerful abilities, and became capable enough to fight against and even force Saitama to get serious before ultimately being defeated.
But there is a bit of a pattern, since every time the series features a build-up to a major fight, Saitama usually ends up finishing the opponent within one or two panels, and such is the nature of One-Punch Man. As of now, Saitama hasn't found anyone strong enough that would push him to the limits.
With Garou killing Genos, Saitama looked highly irritated and angry. He didn't waste a single moment and decided to use one of his killer moves and land a serious punch on Garou.
Genos has the appearance of a 19-year-old boy with a face and hair similar to that of a human.
Fubuki. One-Punch Man Wiki.
Saitama and Tatsumaki's Marriage Life 3&4 + special Translated.
After the Monster Association's downfall, Black Sperm becomes Saitama's pet, alongside Overgrown Rover.