Dean Winchester II, also known as Dean-O 2.0. and Son of Sammy, is a hunter and a member of the Winchester family of hunters. He's the son of
Dean Winchester II is the son of Sam Winchester and an unknown woman, and was named after his deceased uncle Dean Winchester. It is unknown if Dean was also a hunter like his father, however he did have an anti-possession tattoo suggesting Sam at least taught him of the supernatural.
Lisa confirmed to Dean that Ben wasn't his son and his similarities to him was due to her 'type' that she hooked up with that Dean had fallen under.
In the series finale, after Dean dies, Sam leaves the bunker behind for good, taking their dog, Miracle, with him. Over the years, Sam has a family and a son, whom he named after his brother, grows old and dies of natural causes.
Emma Winchester is the daughter of Dean Winchester and Lydia.
Ben is about 11 years old and Dean is acting as his father figure. When a Djinn attacks Dean, Ben and Lisa are moved to Bobby's house for their safety.
Eileen Leahy - Sam's final love (Season 15)
Eileen Leahy (Shoshannah Stern) first showed up in Season 11's “Into The Mystic”, only to be killed a year later (“There's Something About Mary”).
Cassandra Masters is the daughter of Castiel and Meg Masters and the only known Nephalem to exist, which is a hybrid between a union of an angel and demon, even being part human due of Castiel and Meg's human vessels. Cassandra acts as one of the leading main characters with Sam and Dean.
Lydia met Dean Winchester, along with Castiel at a bar. She shared a conversation with the Winchester and then went to her house where the two enjoyed a night together. Unknown to Dean, Lydia was impregnated with his child and in just a couple of hours, Lydia was already nine months pregnant.
Lisa Braeden is a single mother of one, who had a fling with Dean Winchester back in 1999, whilst he was on a hunt in the vicinity. She has a young boy named Ben who shares similarities to Dean, although she has categorically stated that he is not his child.
While trying to cope with his impending death and make the best of his final year, Dean begins to start hunting the freed Demons. Meeting a seemingly helpful demon Ruby, Dean learns that he too may become a demon himself if he burns in Hell too long.
In a 2008 interview, Eric Kripke revealed that Dean is not the father of Ben.
In season six, it is revealed that Frank Delfino is the son of Sam Keating and his sister Hannah. Because Frank is the catalyst behind the car crash that killed Sam in utero, Frank is indirectly responsible for his baby brother's death. Sam, Frank, and Gabriel Maddox are all sons of Annalise's husband, Sam.
Someone, or something, has drawn the Winchesters and archangels to a strange device capable of impregnating anything it touches. Sam and Gabriel end up coming into contact with it, and Sam becomes pregnant.
Adam Millagan is a supporting character in Supernatural. He is the younger half-brother of Sam and Dean Winchester and the son of John Winchester. He appears as a minor character in season 4 and a supporting character in seasons 5 and 15. He also serves as the primary vessel for the Archangel Michael.
Eventually the two comforted each other and slept together, not realizing in a few short months, Meg would be carrying a Nephalem, their unborn child, Cassandra Master. Castiel learned of Meg's pregnancy and did everything in his power to hide her from angels or demons.
Supernatural: Former angel Castiel (Misha Collins) had a very human first on the CW hit drama: He lost his virginity to April (Shannon Lucio)! Alas, it turns out she was a reaper and stabs Cas in the chest, so yeah, no cuddling for those two.
That woman, now vampire, is Jenny – who returns 15 years later in Supernatural's series finale as the leader of the nest of vampires who kill Dean Winchester.
Dean tells Lisa "you knew what you signed up for". Lisa replies, "I did, but I didn't expect Sam to come back". She knew their relationship was "over the moment Sam walked in the door", and tells Dean how weird his and Sam's relationship is. With Sam, Dean can never be happy.
After Cassie's father, a car dealership owner, was killed by the spirit of Cyrus Dorian, Cassie contacted Dean to help her investigate, finally accepting the truth about the supernatural. Despite this, once seeing him again, uneasiness between them remains evident.
Emma was an Amazon conceived by Lydia and Dean during a one-night stand, unbeknownst to the latter. After trying to kill Dean, Sam shot her, killing her instantly.
Live Free or Twihard - Dean is bitten and turns into a vampire.
He became the meat suit for the Archangel Michael…with a twist, of course. It's not the Michael that wanted to go head-to-head with his brother, Lucifer, all those years ago. No, this is the Michael from the apocalypse world.