As far as DC villains female go, Amanda Waller is perhaps the one with the most power and grit. Although her power is not physical, that does not stop some iterations of the character from having great combat abilities. Amanda Waller has ultimate government power.
Wanda Maximoff, later known as Scarlet Witch, is the most powerful female superhero in the Marvel Cinematic Universe. She has the power to singlehandedly tackle Thanos and torment Doctor Strange.
Darth Vader
And so we come to the villain you voted as the best of all time. Darth Vader often appears at the top of these lists, as the character has had more of a lasting impact than the blast that took out Alderaan.
Lesla-Lar: Supergirl's first serious enemy, Lesla-Lar was a Kandorian scientist envious of Supergirl. She impersonated the Maid of Might, planning to use Lex Luthor's assistance to kill Superman and then killing Luthor and taker over the world. Later she attempted to possess Supergirl's body.
Captain Marvel/Carol Danvers ('Captain Marvel')
As brought to life by Brie Larson, Danvers is considered to be Marvel's most notable female hero and one of the most powerful characters in the franchise.
The Deadliest Woman in the Galaxy
Thanks to being trained by Thanos, Gamora knows just about everything there is to know about combat and killing. She is an expert with any weapon, and even once wielded the Godslayer sword.
The High Evolutionary in Guardians of the Galaxy Volume 3 is the most evil villain the MCU has seen in recent years. Chukwudi Iwuji as the High Evolutionary might be the most villainous villain in all of the Marvel Phases we've seen play out on-screen.
1. Thanos (Avengers: Infinity War, Avengers: Endgame)
Darkseid is often considered one of the most powerful villains in the DC Universe and is a force of evil so powerful he tends to be treated as the final threat in other media from the DC Animated Universe to the final season of Smallville.
The Joker. First appearing in Batman #1 in 1940, the Joker has become one of the most recognizable and beloved villains in all of fiction.
The One Above All is the single most powerful entity in the universe. He is omnipotent, omnipresent, omniscient, and all-powerful. His power is infinite and he can both create or destroy the entire multiverse.
A blue whale can generate a maximum force of approximately 60 kilonewtons. Whales can claim the title of the strongest creature on the planet simply due to their enormous size. Although unable to lift, grip, or kick, they do need an enormous amount of force to power their massive bodies through the water.
When counting down the most powerful DC cosmic characters of all time, the number one has to be DC's version of God known as The Presence. While there are numerous Gods in the DC pantheon, mostly from the Greek versions of Zeus and his offspring, the Presence is more powerful than them all.
Plus, Wonder Woman has magic on her side. She wields a mystical sword that cuts electrons off of an atom, and she knows how to use it. Then there is her record of harming Superman in battle. Wonder Woman can take the Man of Steel down if she's serious.
Ursa (Sarah Douglas) is one of the Kryptonian Villains that takes over the world. She appears in both the 1978 film "Superman" and the 1984 film, "Superman II". In "Superman", Ursa is a co-conspirator of General Zod (Terrence Stamp) during his attempt to take control of Krypton.
Catwoman, the very first of the female super villains, is Selina Kyle, but in her first appearance, she was known only as "The Cat," and did not appear in costume.
Elizabeth "Betty" Ross, also known as Red She-Hulk and currently Harpy, is a major character in "The Hulk" series of the wider Marvel Comics franchise.