Before he is able to regenerate fully, Tamayo appears and uses her Blood Demon Art to keep him in place, while using a drug that can turn him into human. Using this opportunity, Gyomei Himejima appears and destroys Muzan's head.
Gyomei used his weapon to hold him back while Sanemi, Giyu, and Tanjiro used their Breathing techniques to attack him. With the collective efforts of every member of the Demon Slayer Corps present there, Muzan turned to dust as sunlight came in contact with his body.
Yoriichi defeated Muzan in an instant, but he had a question for him before eliminating him, which allowed Muzan to escape.
Yoriichi Tsugikuni, the first swordsmen to ever use Breathing Styles, once nearly killed Muzan with Sun-Breathing, and Muzan has been both physically and psychologically scarred ever since.
Don't go! DON'T LEAVE ME HERE! Muzan speaks his final words as he loses control over Tanjiro.
It is revealed that Muzan's true fear of dying and immense desire to live and survive was due to him being born "dead," where his heart would constantly stop in his mother's womb and was assumed stillborn until he fought to breathe before his cremation.
The two known demons who broke free of Muzan's curse are Tamayo and Nezuko. Tamayo was able to break free of the condemnation when Yoriichi fought Muzan, nearly killing him in the process. During this weakened state, Yoriichi let Tamayo go, free her from Muzan, and free her from the curse.
Alucard from Hellsing Ultimate is not your regular bloodsucking vampire. He's one of the anime characters who could potentially defeat Muzan Kibutsuji with a single blow. Alucard is known for his cold, calculating personality, which is matched only by his incredible powers.
Yoriichi Tsugikuni was the first Demon Slayer and also the one who invented Breathing Techniques in the first place. Yoriichi was born with the Demon Slayer mark and prowess in swordsmanship. His powers were beyond comparison as he defeated Muzan once and had him on the verge of death until he managed to escape.
The only reason why Muzan hates Doma is because of his insincerity and lack of emotions. This might sound odd, expecting emotions from a demon, but even a demon has to retain such tendencies to keep things in order.
In the first few arcs of the series, the identity of the demon that killed Tanjiro's family was a mystery. It is later revealed that it was none other than the series' main antagonist, Muzan Kibutsuji.
Sanemi managed to survive the battle against Muzan, if just barely. Unconscious and straddling the edge of death, Sanemi chose not to go to Heaven with his siblings, but to lovingly join his mother in Hell because she'd killed most of her children after she became a demon.
Some of the characters who have faced Yoriichi and survived
This happened due to a treatment that had gone wrong. While he was being treated, Muzan killed the doctor because he was not able to observe any results.
He realized he was running on borrowed time, but still took on Kokushibo and defeated him. Then, Gyomei joined forces with the other Hashira to defeat Muzan. His death scene was one of the series' most heartbreaking. He peacefully died after losing his leg during the fight against Muzan.
The warrior Muzan feared was a swordsman named Yoriichi Tsugikuni. Yoriichi was the only slayer before Tanjiro who came close to killing Muzan, and the flashback of their fight occurred in Chapter 187.
Tanjiro decapitates Akaza with the Hinokami Kagura: Setting Sun Transformation. Akaza was bewildered, wondering how Tanjiro did not have any fighting spirit, comparing this feeling to fighting against a plant. He acknowledges that Tanjiro surpassed his speed.
The only character who was stronger than Muzan was Yoriichi. He almost beat Muzan before splitting his body into 1800 parts in an attempt to escape.
"Based on this analysis, it seems clear that Sukuna has the edge in terms of power and abilities. He is stronger, faster, and more durable than Muzan, and he has a wider range of abilities at his disposal. Additionally, Sukuna's regeneration abilities would make it difficult for Muzan to kill him.
It is revealed that Tamayo's drug had an aging potion mixed in along with the Demon antidote. Due to this, Muzan has aged 9,000 years within the span of three hours.
The Wind Hashira is one of the strongest Hashiras in the Demon Slayer series. He played a significant role in defeating Kokushibo and was able to inflict damage on Muzan. Sanemi's sheer power and speed will be able to overwhelm Nezuko even in her final form.
1 Muzan (Demon Slayer)
Without that antidote, it would have been impossible to kill him. So despite all her strength and humanity, Nezuko would have easily lost to Muzan.
So, in conclusion, her coming from a Sun Breathing user's lineage and not relying on human substance are perhaps the reasons for her immunity. Hence, Muzan was searching for the Blue Spider Lilly, a flower that was a crucial ingredient in the medicine used by the doctor who saved his life.
Since he didn't know anything about the Blue Spider Lily medicine, he needed others to find the plant for him by happenstance. This is the general reason why Muzan turned Nezuko into a demon. More specifically though, was the fact that Nezuko was of Kamado blood.
Akaza was also one of Muzan's favorite demons out of all his subordinates. The reason behind this is Akaza's extreme loyalty to his master. The Upper Rank Three demon was always sent away on special missions, something the Upper Rank 1 and 2 were often denied of.