Azazel aka the Yellow-Eyed Demon (Fredric Lehne) was the thing that killed Sam and Dean's mother; he was the thing that stood over Sam's crib and dripped blood into his mouth, turning him into one of his future soldiers; he was the reason the Devil's Gate opened; and he was the reason, ultimately, that Dean sold his ...
01. Mary Winchester (Samantha Smith) Targeted by Azazel, retired hunter Mary had the distinction of being the first character to meet her maker. The Yellow-Eyed Demon pinned Mary to the ceiling of baby Sam's room, slit her stomach, and eventually set her ablaze.
It is revealed that she was killed because she interrupted the demon as he fed his blood to baby Sam. Sam learns for the first time that he was fed demon blood, and that Mary knew the demon that killed her.
He wishes it didn't happen. Dean is barely holding it together. He doesn't like that Jack is calling Mary's death, “the accident.” But he plays along and says they understand and they forgive Jack.
We find out Sam and Dean's dad John was first killed by Azazel in 'In the Beginning' (season four, episode three) and is resurrected by Azazel when Mary makes a deal to allow the demon entry to her house in ten years.
Before dying, John tells Dean, if he can't save Sam, he'll have to kill him, should he become evil. The fourth season episode "On the Head of a Pin" reveals that the demon Alastair tortured John in Hell for over a century, with John refusing the demon's offer to stop if he himself would torture someone else.
Azazel appears to Sam in a dream, and states that his plan is for the children with special powers to fight amongst themselves until the strongest is left to lead the demon army. He tells Sam that he, with his leadership qualities and hunter training, is his favorite.
Emma was an Amazon conceived by Lydia and Dean during a one-night stand, unbeknownst to the latter. After trying to kill Dean, Sam shot her, killing her instantly.
Not only does Dean die on a routine vampire hunt, passing away slowly in his brother's arms (which coincidentally may be the best scene in the entire final season), but he's briskly whisked away into Heaven solo.
Jack uses his powers to heal Cas because the antidote obtained via the best plan of all time unfortunately doesn't work. When he tries to also heal Dean, though, Cas won't let him; he's confident Dean will heal (because he's Dean, and Dean is Dean) and Jack is being entirely too cavalier about his soul.
When Jack killed Mary Winchester, he sought to redeem himself by creating new angels but it didn't help and he was locked away by the Winchesters. Jack escaped and roamed Earth before he was confronted by the Winchesters who intended to kill him but stopped.
Season 12. Dean is both overjoyed and shocked to see his mother again, while Mary is confused and initially unaware who Dean is, since she remembers him as a 4-year-old boy. Mary attacks him and Dean is forced to reveal to Mary that she has been dead for 33 years, and that he is indeed her son.
Jack subsequently regains his powers after killing Michael and absorbing his grace. However, killing Michael burns away a great deal of Jack's soul, leaving him soulless.
After a soulless Jack kills Nick for trying to resurrect Lucifer, he accidentally kills Mary in a brief fit of rage. Mary is reunited with her husband in Heaven and is now at peace in a shared Heaven with John.
When Sam was six months old, his mother Mary (a retired creature hunter) was engulfed in a massive conflagration by yellow-eyed demon Azazel (one of four Princes of Hell).
Here there is the idea that God's heritage (the created world) is largely under the dominion of evil – i.e., it is "shared with Azazel" (Abr. 20:5), again identifying him with the devil, who was called "the prince of this world" by Jesus. (
Death reveals his true intention behind giving Dean his ring; to teach Dean a lesson. Death tells Dean that messing up the natural order is hard when you're the one that has to clean it up.
Supernatural's Dean and Sam are no strangers to death. In fact, the duo have died — and been resurrected — over an astounding 100 times, proving that you just can't keep a Winchester down.
In the end, Dean (Jensen Ackles) went out the way he always thought he would: Hunting. He was killed in the series finale while taking on a nest of vampires, but his ultimate end would come in the show's final moments, when he was reunited with Sam (Jared Padalecki) in heaven.
Cassandra Masters is the daughter of Castiel and Meg Masters and the only known Nephalem to exist, which is a hybrid between a union of an angel and demon, even being part human due of Castiel and Meg's human vessels. Cassandra acts as one of the leading main characters with Sam and Dean.
When Dean had first met Ben Dean considered the possibility that Ben might actually be his son. Lisa confirmed to Dean that Ben wasn't his son and his similarities to him was due to her 'type' that she hooked up with that Dean had fallen under.
After Dean's death, she was adopted by Ben Warren and Miranda Bailey.
Originally, Dean had tried to get Adam out of hell, too, but Death made him pick between Sam's soul and Adam. Dean naturally chose Sam's soul. If nothing else, it was a nice reminder that Adam had not been completely forgotten by the brothers. (Erm, I know I had.)
Within a moment's notice, Lucifer dropped a major bombshell on Sam — and the entire "SPN" fandom — by admitting HE was the one sending Sam visions of the Cage, not God.