Clexane should not be used in People with conditions that carry a high risk of uncontrolled bleeding, for example the blood clotting disorder haemophilia, a peptic ulcer, a recent stroke caused by bleeding in the brain (haemorrhagic stroke) or a reduced platelet count in the blood (thrombocytopenia).
Do not take Clexane if you have or have had major bleeding disorders, injury to the brain, stomach or bowel problems, or bacterial infections of the heart. Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
Are there any side effects? Less serious side effects include pain, bruising, bleeding, swelling, itch, or rash at the injection site. Serious side effects include allergic reactions, signs of abnormal bleeding such as prolonged bleeding or bruising easily, nausea, gut pain, or numbness.
Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Enoxaparin may cause bleeding problems.
Heparin (applies to Clexane) hypertension
Heparin should be used with extreme caution in patients with uncontrolled or severe hypertension as these conditions may predispose the patient to hemorrhage during heparin administration.
Anticoagulation should be avoided in patients with absolute contraindications, such as in the following conditions: Active bleeding. Coagulopathy. Recent major surgeries.
It can cause a rapid decrease in blood pressure, which may be dangerous to the patient.
Remember: Do not inject yourself within 5 centimetres of your belly button or around existing scars or bruises. Change the place where you inject between the left and right sides of your stomach; depending on the area you were last injected.
The most common adverse reactions were bleeding, anemia, thrombocytopenia, elevation of serum aminotransferase, diarrhea, and nausea.
The approach combines Clexane with the steroid Prednisone. Injections continue until at least 12 weeks gestation. The research suggests a 53% pregnancy rate.
Direct subcutaneous injection should be given into a subcutaneous tissue skinfold of the abdomen or the upper-outer aspect of the thigh. The skinfold should be held throughout the injection. After removal of the needle, do not rub the site. Rather, place firm, even pressure to the site of injection for 1-5 minutes.
IMPORTANT WARNING:
If you experience any of the following symptoms, call your doctor immediately: numbness, tingling, leg weakness or paralysis, and loss of control over your bladder or bowels. Talk to your doctor about the risk of taking enoxaparin. Keep all appointments with your doctor.
Black Box Warning — When spinal puncture or epidural/spinal anesthesia is employed, patients anticoagulated or scheduled to be anticoagulated with low molecular weight heparins or heparinoids are at risk of developing an epidural or spinal hematoma which can result in long-term or permanent paralysis.
Descriptions. Enoxaparin injection is used to prevent deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism.
Are there any alternatives to clexane injections? During pregnancy there is no alternative treatment for a DVT. After your baby is born Warfarin tablets may be an appropriate alternative for you. Compression stockings may be prescribed to reduce your risk of developing a clot but they will not prevent it.
Clexane Multidose Vial should be injected just under the skin on your stomach, but not too near the belly button or any scar tissue (at least 5cm away from these).
If you do not need to discard any medicine from the syringe, do not expel the little air bubble before injecting the medicine. It helps push the medicine into the body so it will not leak out the injection site.
Clexane is given either once or twice daily, depending on the underlying medical condition. Patients with mechanical heart valves are more likely to need an injection both morning and night.
Some people can't take anticoagulants, because they have a higher risk of having a serious problem if bleeding occurs. For example, you may have a higher risk of bleeding if you have uncontrolled high blood pressure, have kidney or liver disease, or drink large amounts of alcohol.
Having surgery
As anticoagulants reduce the ability of your blood to clot, there's a risk you could experience heavy bleeding if any kind of cut (incision) is made during a procedure. You may therefore be advised to stop taking your medicine before surgery.
If a person has a high risk of bleeding, then anticoagulants including DOACs and warfarin, may not be recommended. DOACs are not recommended for people who have a mechanical heart valve. If you have kidney damage, DOACs may not be recommended, as it can increase the risk of bleeding for some people.
Extra care is needed because enoxaparin is a high-alert medicine. High-alert medicines have been proven to be safe and effective. But these medicines can cause serious injury if a mistake happens while taking them. This means that it is very important for you to know about this medicine and take it exactly as directed.
The risk of HITS is higher in women and surgical patients compared with medical patients, and five- to 10-fold higher in patients receiving UHF compared to LMWH. Although rare, LMWH-induced thrombocytopaenia can occur and some cases have been reported in acute coronary syndrome.
Background: The combination of aspirin, clopidogrel, and enoxaparin (combination therapy) is the standard treatment for acute coronary syndrome but is associated with gastrointestinal bleeding.