Antihistamines such as hydroxyzine (Atarax, Vistaril) interfere with the mast cells' release of histamine, helping to relieve bladder inflammation and pain, urinary frequency, and nighttime voiding.
Antihistamines, such as diphenhydramine (Benadryl, others) and loratadine (Claritin, others), which may reduce urinary urgency and frequency and relieve other symptoms.
Histamine contributes to the pain and inflammation in bladder conditions including painful bladder syndrome / interstitial cystitis (PBS/IC). You don't have to have PBS/IC to experience bladder irritation from histamines.
Trouble is, certain antihistamines can relax the bladder, blunting its ability to push out urine.
Nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), to relieve pain. Tricyclic antidepressants, such as amitriptyline or imipramine (Tofranil), to help relax your bladder and block pain.
Though the most widely used antihistamine to treat IC/BPS is hydroxyzine, some people with IC/BPS find relieve from Claritin, Benadryl, and Singulair.
The exact cause of interstitial cystitis isn't known, but it's likely that many factors contribute. For instance, people with interstitial cystitis may also have a defect in the protective lining (epithelium) of the bladder. A leak in the epithelium may allow toxic substances in urine to irritate your bladder wall.
Antihistamines such as hydroxyzine (Atarax, Vistaril) interfere with the mast cells' release of histamine, helping to relieve bladder inflammation and pain, urinary frequency, and nighttime voiding.
Hydroxyzine hydrochloride is an antihistamine that is used for treating allergic and inflammatory skin conditions – it can be used in the treatment of interstitial cystitis/painful bladder syndrome as it blocks the chemicals that can cause inflammation.
Dimethylsulfoxide — Dimethylsulfoxide (DMSO) is a liquid medication that has been approved by the US Food and Drug Administration (FDA) to treat interstitial cystitis/bladder pain syndrome (IC/BPS). DMSO is put into the bladder through a temporary catheter and is held in place for approximately 20 minutes, if possible.
Furthermore, IC has been shown to be associated with autoimmune diseases such as systemic lupus erythematosus, Sjögren's syndrome and autoimmune diseases of the thyroid gland.
This data demonstrates that there is a higher prevalence of IC in patients who use hormones, whether for contraceptive purposes or not, and supports the theory that estrogen contributes to the development of autoimmunity, specifically IC.
Allergies. Another theory is that an allergic component with release of specific inflammatory cells known as mast cells occurs in the bladder and can lead to IC in some people. This inflammatory reaction is similar to people with other allergic conditions such as eczema and seasonal or environmental allergies.
Researchers tested amitriptyline, the TCA most commonly used to treat IC/BPS, in a randomized, prospective, placebo-controlled trial for IC/BPS. The researchers found that symptom scores dropped, and that pain and urinary urgency improved significantly in the amitriptyline group compared with the placebo group.
Coffee, soda, alcohol, tomatoes, hot and spicy foods, chocolate, caffeinated beverages, citrus juices and drinks, MSG, and high-acid foods can trigger IC symptoms or make them worse.
Patients with IC often avoid Vitamin C as it tends to flare symptoms. More sensitive patients avoid multivitamins as it is difficult to find one without vitamin C. Those patients who have their IC more under control can tolerate some specially buffered Vitamin C and benefit from the IC Multi.
In the early phase of IC the symptom flares are intermittent in most patients. Over time symptoms increase and pain cycles may appear and last for 3-14 days.
Tablets or capsules may be used to treat people with BPS (interstitial cystitis). These include: over-the-counter painkillers – such as paracetamol and ibuprofen. medicines for nerve pain – such as amitriptyline, gabapentin and pregabalin.
B6 Mouse Strain: The Best Fit for LPS-Induced Interstitial Cystitis Model.
Interstitial cystitis/bladder pain syndrome (IC/BPS) has several well-known comorbid psychiatric manifestations, including insomnia, anxiety, and depression. We hypothesized that somatoform disorder, which is a psychosomatic disease, can be used as a sensitive psychiatric phenotype of IC/BPS.
Interstitial cystitis is a severely debilitating disease of the urinary bladder. Symptoms of interstitial cystitis include excessive urgency and frequency of urination, suprapubic pain, dyspareunia and chronic pelvic pain. Interstitial cystitis interferes with employment, social relationships and sexual activity.
Stress does not cause IC, but if you have IC, stress can cause a flare. Physical stress and mental stress can lead to flares. Remember, every flare will settle down and worrying about it only prolongs the discomfort. Understanding stress and how to minimize it is the best way to limit the intensity of your flares.
Non-steroidal anti-inflammatory drugs (NSAIDs) Ibuprofen (Advil, Motrin and Nuprin) Ketoprofen (Orudis) Naproxen sodium (Aleve and Anaprox)
Best Probiotics for Cystitis
Both Lactobacillus rhamnosus GR-1® and Lactobacillus reuteri RC-14® can be found in Optibac Probiotics For Women.