The active ingredient in Ozempic is semaglutide, which works by inducing satiety. This feeling of being satisfied or “full”, suppresses appetite. This is why it works for weight loss. Semaglutide also helps the pancreas produce insulin, which is how it helps manage type 2 diabetes.
About a third of people who take Ozempic for weight loss will lose 10% or more of their body weight. Most people should expect to lose at least 5% of their starting body weight when using Ozempic for weight loss.
The prescription drug Ozempic helps people with diabetes control their blood sugar. But its wild popularity is due to a side effect: rapid weight loss.
Ozempic is a once-weekly injectable medication formulated to help adults with type 2 diabetes manage their blood sugar. Although not officially a weight loss drug, research suggests that people who take Ozempic may lose modest amounts of weight while on the medication.
How Long Does It Take To Lose Weight On Ozempic? Patients who start taking Ozempic can start noticing significant weight loss after several weeks. According to clinical trials, adults lost 9 to 12 pounds on average within 56 weeks after starting Ozempic treatment.
So, on average, with the recommended starting Ozempic dose of 0.25 mg, a 500 to 1000 calorie reduced diet, and exercise 3 times a week, you can expect to lose 3-5 pounds in the first month of treatment, which works out to about 3% of body weight for most overweight or obese individuals.
Ideally, you should not take Ozempic if you do not have diabetes, or if you're pregnant, breastfeeding, or planning on becoming pregnant. Ozempic may cause serious (but rare) side effects, including thyroid C-cell tumors and medullary thyroid carcinoma (MTC).
Just as with starting a new medication, stopping one causes a sudden shift in the body. New reporting in The New York Times and The Wall Street Journal suggest that ceasing Ozempic can be especially hard on the body, leading to rapid weight gain and other jarring disruptions.
Some individuals may actually gain more weight after stopping an obesity drug than they initially lost, Conde-Knape added. Studies have similarly shown weight rebound in people who stop taking Ozempic.
If people are unable to eat enough while on the drug, he decreases the dose or tells them to stop taking the medication altogether. No standard nutritional guidelines have yet been established for patients taking Ozempic or other medications that work similarly, like Wegovy and Mounjaro.
This special type of intra-abdominal fat is almost impossible to lose and it does not come off with weight loss, which is why people with T2D who lose weight on drugs like Trulicity, Ozempic, and Mounjaro reduce their subcutaneous fat.
Ozempic® (semaglutide): It's one of several GLP-1 medications that are best known for their ability to help patients with type 2 diabetes control blood sugar—but the drug is also effective in helping those with obesity or overweight improve their metabolic health and lose weight.
Ozempic to ramp up production driven by off-label demand
"There's nothing better than you not only losing weight, but also overall eating much healthier food." For those on the drug, Rubin recommends increasing your intake of lean protein such as chicken, turkey, fish, eggs, beans, soy and low-fat dairy.
Elon Musk and Chelsea Handler are among the few big names who have admitted to using the drug for weight loss, though Handler said she stopped using it after learning it was intended for those with diabetes. But experts say most celebrities who use Ozempic are likely keeping their lips sealed.
The starting Ozempic dosage is usually 0.25 mg once weekly. This dose isn't intended to have an effect on your blood glucose. Instead, it's meant to help your body start adjusting to digestion-related side effects.
Like many drugs, the effects of semaglutide stop when patients go off of it, so some people regain weight. Experts said they consider Ozempic and Wegovy to be lifelong medications.
“Ozempic face” is a term for common side effects of the type 2 diabetes medication semaglutide (Ozempic). It can cause sagging and aging of facial skin. A doctor may recommend lifestyle modifications or facial fillers to treat these effects.
Stars like Chelsea Handler, Kyle Richards and more have spoken about the diet trend. Handler, for her part, admitted during a January 2023 episode of the “Call Her Daddy” podcast that she unknowingly took the medication.
Semaglutide (Ozempic, Wegovy, Rybelsus) can cause side effects that some people are unable to tolerate. Following dosing guidelines can help manage these side effects. Nausea, vomiting, and diarrhea are the most common semaglutide side effects.
In patients with diabetes, one study showed that taking Ozempic at the highest dose of 2 mg led to on average ~15 lbs (6.9 kg) weight loss after 40 weeks.
Results showed that patients lost on average up to 14 lb (6.4 kg), although some people also gained weight. Study 1: Patients using Ozempic 0.5 mg dose lost on average 8 lb (3.6 kg), those using 1 mg dose lost 10 lb (4.5 kg), and those taking placebo (an inactive treatment) lost 3 lb (1.4 kg).
High fat foods or sugary foods
Ozempic can cause nausea and vomiting if taken after eating foods high in fat or sugar. It is recommended that you take Ozempic before meals, rather than after, to minimise any potential side effects from eating high-fat or high-sugar foods.