Public Citizen petitioned the FDA in 2004 and 2005 to recall Crestor. The advocacy organization's health research group documented cases of patients who developed rhabdomyolysis after taking the drug. Rhabdomyolysis is a severe form of muscle damage that can lead to permanent kidney damage, coma and sometimes death.
CRESTOR® (rosuvastatin) may cause serious side effects, including: Muscle pain, tenderness, and weakness (myopathy). Muscle problems, including muscle breakdown, can be serious in some people and rarely cause kidney damage that can lead to death.
Statin Alternatives to Crestor
Lipitor is another high-intensity statin, like Crestor. Other statin alternatives to Crestor include: Altoprev (lovastatin) Lescol XL (fluvastatin)
Patients taking Crestor are eight times more likely to develop rhabdomyolysis, nephropathy, renal failure or proteinuria than patients taking Pravachol, and 6.5 times more likely to develop those complications than patients taking Lipitor, said a study, published today in Circulation, Journal of the American Heart ...
Like other statins, Crestor lowers total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. However, it causes significantly better reductions in total cholesterol at lower doses compared to the other drugs in this class (Jones, 2003).
In relation to renal function, atorvastatin was the safest statin as it resulted in the least number of patients at the end of 2 years of treatment with the new onset of microalbuminuria (10.9%) followed by rosuvastatin (14.3%) and then pravastatin (26.6%).
The most common side effects of Crestor include headaches, abdominal pain and nausea. Serious side effects of Crestor may include muscle pain, tenderness and weakness, or myopathy. Crestor may increase the risk of diabetes, liver damage and hemorrhagic stroke.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so.
Suddenly stopping your statin is dangerous. Data shows that the risk of stroke, heart attack, and death within 4 years of stopping a statin is high.
Bempedoic Acid: A Statin Alternative to Reduce Cholesterol
Statins reduce heart attacks and strokes, which is why they're first-line therapy, but those side effects can be a problem for people. Bempedoic acid is sold under the brand name Nexletol on its own and as a combination drug with ezetimibe called Nexlizet.
A Statin Alternative Lowers Heart Attack Risk by 23 Percent, Drug Trial Shows. People who can't or won't take statin medications to reduce LDL cholesterol may want to talk to their doctor about bempedoic acid (Nexletol).
You should not take rosuvastatin if you are allergic to it, or if you have: liver disease; or. if you are pregnant or breast-feeding.
These statins, including atorvastatin (Lipitor®), simvastatin (Zocor®) and fluvastatin (Lescol®), are more likely to cause muscle aches. The hydrophilic statins, including rosuvastatin (Crestor®) and pravastatin (Pravachol®), have to be actively transported and cause fewer muscle aches.
Statins can stabilize cholesterol plaque already attached to artery walls, making it less likely to get worse or rupture, causing a heart attack or stroke. "Statins also help remove cholesterol from you blood by causing the liver to express more LDL cholesterol receptors that take cholesterol out of your blood," Dr.
While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people. Rarely, they may cause liver damage.
If you quit cold turkey, your body can go into shock. It is not recommended that you stop statins suddenly if you have a history of heart attack or stroke, as it can put you at a higher risk of recurrent heart attack. You should speak with your doctor before stopping the medicine under any circumstance.
Along with diet, CRESTOR lowers bad (LDL) cholesterol and slows plaque buildup in arteries as part of a treatment plan to lower cholesterol to goal. You may see results for lowering your bad cholesterol as soon as 2-4 weeks after starting CRESTOR.
People who did take statins consumed more calories and fat over time, and gained more weight. The study also showed that statin users had a faster increase in body mass index (BMI) than those who didn't use statins.
have liver or kidney problems. are trying to get pregnant, are already pregnant or are breastfeeding. have lung disease. have ever had a muscle disorder (including fibromyalgia), or a close relative has had a muscle disorder.
Conclusion
Rosuvastatin 5 mg has a greater effect on serum LDL-C reduction as compared to atorvastatin 10 mg. However, its effect on reduction of serum total cholesterol, TG, and HDL-C is the same as atorvastatin.
There isn't one best statin to take. No individual statin has been proven to be best at preventing heart attacks and strokes. But there is evidence that rosuvastatin and atorvastatin decrease harmful cholesterol more than other statins. Some people will clearly benefit from taking a statin.
If you have very high cholesterol and are at high risk of heart attacks or strokes, a specialist may prescribe 40mg a day. This dose is not suitable for everyone. high cholesterol – 5mg to 10mg, taken once a day. Your doctor may increase your dose every 4 weeks up to 20mg a day.