Different diseases, such as Cushing syndrome and Addison disease , can lead to either too much or too little production of cortisol. Measuring blood cortisol level can help diagnose these conditions. It is also measured to evaluate how well the pituitary and adrenal glands are working.
Blood samples are usually taken twice during the day--once in the morning when cortisol levels are at their highest, and again around 4 p.m., when levels are much lower. For a cortisol urine test, your provider may ask you to collect all your urine during a 24-hour period.
Addison's disease is caused by damage to the adrenal glands. The adrenal glands sit just above the kidneys. As part of the endocrine system, they make hormones that affect almost every organ and tissue in the body. Damage to these glands results in too little of the hormone cortisol and, often, the hormone aldosterone.
Secondary adrenal insufficiency happens when the pituitary gland fails to produce adequate amounts of ACTH, leading to a lack of cortisol production by the adrenal glands and thus low cortisol levels. Causes of secondary adrenal insufficiency may include: Autoimmune disease. Pituitary tumors or infection.
Common signs and symptoms of excess cortisol include weight gain (especially in the face and abdomen), fatty deposits between the shoulder blades, diabetes, hypertension, hirsutism in women, proximal muscle weakness, and osteoporosis.
Addison's disease can develop if your immune system attacks your adrenal glands and severely damages your adrenal cortex. When 90% of the adrenal cortex is destroyed, your adrenal glands will not be able to produce enough of the steroid hormones cortisol and aldosterone.
High cortisol levels can also cause inflammation of your digestive tract and throw off the balance between the beneficial and harmful bacteria that live in your digestive tract. Stress can also affect the muscles of your intestines, which prevents your bowels from filtering out harmful gut bacteria.
Adding in cardio, such as a brisk walk will help lower your cortisol levels and control your stress. Once you have your stress under control, you can add interval training and sprints two or three times a week to reduce your belly fat.
Adrenal gland tumors or disease.
Problems with the adrenal glands can cause them to make too much cortisol. The most common is a tumor in the outer part of the adrenal gland called an adrenal adenoma. These tumors are not cancer, and only some make too much cortisol.
Proper thyroid function helps to maintain a healthy metabolism, but both high and low cortisol levels can impair the conversion of thyroid hormone from its inactive form to its active from. This can result in a low thyroid situation, causing weight gain and symptoms of poor metabolism.
Symptoms said to be due to adrenal fatigue include tiredness, trouble falling asleep at night or waking up in the morning, salt and sugar craving, and needing stimulants like caffeine to get through the day. These symptoms are common and non-specific, meaning they can be found in many diseases.
Larger changes in cortisol levels, reflecting a healthier circadian rhythm of the HPA axis, were associated with better subjective sleep quality, but not with objective sleep quality. It is well-known that cortisol secretion, the end product of the HPA axis, is associated with the sleep–wake cycle [13].
Cortisol, the primary stress hormone, increases sugars (glucose) in the bloodstream, enhances your brain's use of glucose and increases the availability of substances that repair tissues. Cortisol also curbs functions that would be nonessential or harmful in a fight-or-flight situation.
Lack of cortisol can cause adrenal crisis, a preventable condition that can cause death if treated improperly. Deaths from adrenal crisis can be prevented if patients and their families recognize the condition and are careful to treat it right away. Adrenal crisis is a medical emergency.
Although there's no cure, primary adrenal insufficiency can be managed effectively by taking cortisol and aldosterone replacement hormones, with the goal of stabilizing hormone levels and relieving signs and symptoms.
If you have adrenal insufficiency, your provider will refer you to an endocrinologist — a hormone specialist.
Symptoms of Cushing's syndrome
Weight gain around the abdomen, and obesity. Wasting of the limbs. A 'buffalo' hump of fat high on the back. Round, red and puffy-looking face ('moon face')
People with Cushing's syndrome may see their face get round ("moon face"), they gain weight in unusual ways, bruise easily or feel weak, tired and sad. Women and men may also notice fertility and other problems. CS is most often found in adults between the ages of 20 and 50.
Too little cortisol may be due to a problem in the pituitary gland or the adrenal gland (Addison's disease). The onset of symptoms is often very gradual. Symptoms may include fatigue, dizziness (especially upon standing), weight loss, muscle weakness, mood changes and the darkening of regions of the skin.