Hydroxyzine hydrochloride is an antihistamine that is used for treating allergic and inflammatory skin conditions – it can be used in the treatment of interstitial cystitis/painful bladder syndrome as it blocks the chemicals that can cause inflammation.
Antihistamines such as hydroxyzine (Atarax, Vistaril) interfere with the mast cells' release of histamine, helping to relieve bladder inflammation and pain, urinary frequency, and nighttime voiding.
Antihistamines, such as diphenhydramine (Benadryl, others) and loratadine (Claritin, others), which may reduce urinary urgency and frequency and relieve other symptoms.
The antihistamine (such as Zyrtec®) is used because biopsies in patients with IC show an increased number or Mast cells, which are a particular type of white blood cell that are attracted to the site of injury by histamine. The mast cells further increase the local inflammation and pain.
Antihistamines
“The bladder is a smooth muscle that fills up with urine. When it reaches a certain level and is full, it sends signals to the brain that it's time to urinate,” he explains. Trouble is, certain antihistamines can relax the bladder, blunting its ability to push out urine.
Antihistamines for IC/BPS
Though the most widely used antihistamine to treat IC/BPS is hydroxyzine, some people with IC/BPS find relieve from Claritin, Benadryl, and Singulair.
Oral antihistamines (Diphenhydramine, Benadryl, Zyrtec, Claritin, Allegra and their generics) weaken the bladder contractions. This lessens the bladder's ability to expel the urine.
Nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), to relieve pain. Tricyclic antidepressants, such as amitriptyline or imipramine (Tofranil), to help relax your bladder and block pain.
Things you can do to help BPS (interstitial cystitis)
Things that may help improve your symptoms include: reducing stress – try exercise, warm baths and mindfulness-based meditation techniques. making sure you are hydrated regularly throughout the day.
Dimethylsulfoxide — Dimethylsulfoxide (DMSO) is a liquid medication that has been approved by the US Food and Drug Administration (FDA) to treat interstitial cystitis/bladder pain syndrome (IC/BPS). DMSO is put into the bladder through a temporary catheter and is held in place for approximately 20 minutes, if possible.
Coffee, soda, alcohol, tomatoes, hot and spicy foods, chocolate, caffeinated beverages, citrus juices and drinks, MSG, and high-acid foods can trigger IC symptoms or make them worse.
Medication. Types of oral medication include muscle relaxants such as Oxybutynin which can calm the contractions of the bladder muscle – also used for an overactive bladder. Anti-inflammatories such as Diclofenac can reduce the inflammation and antihistamines such as hydroxyzine can be used.
-Drinking plenty of fluids: This will help to keep the urine diluted and reduce irritation. -Taking over-the-counter pain medication: This can help to relieve pain and inflammation. Tylenol is better than Motrin or Advil. -Using a heating pad: This can help to soothe pain and cramping.
Upon the activation of mast cells, histamine is released; and the binding of histamine to the receptors on bladder wall could induce inflammation and hypersensitivity of the bladder [7, 8].
Allergies. Another theory is that an allergic component with release of specific inflammatory cells known as mast cells occurs in the bladder and can lead to IC in some people. This inflammatory reaction is similar to people with other allergic conditions such as eczema and seasonal or environmental allergies.
Pain is often a later symptom but many patients may never develop it. In the early phase of IC the symptom flares are intermittent in most patients. Over time symptoms increase and pain cycles may appear and last for 3-14 days.
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Interstitial cystitis (IC) is a chronic and painful condition of the bladder. People with IC have a bladder wall that is tender and easily irritated, leading to uncomfortable symptoms. Although IC currently has no cure, the symptoms can be managed to help you feel better and live more comfortably.
Stress does not cause IC, but if you have IC, stress can cause a flare. Physical stress and mental stress can lead to flares. Remember, every flare will settle down and worrying about it only prolongs the discomfort. Understanding stress and how to minimize it is the best way to limit the intensity of your flares.
Bladder instillation for interstitial cystitis (also called a bladder wash or bath), a procedure in which the bladder is filled with a therapeutic solution that is retained in the bladder for varying periods of time, from a few seconds to 15 minutes, before it is drained through a catheter.
Whether you know Charlotte McKinney from Baywatch, Dancing With The Stars, or one of her many ad campaigns, what you probably don't know is that she suffers from a chronic bladder condition called interstitial cystitis.
Urinary retention can also be caused by certain medications. Drugs like antihistamines (Benadryl®), antispasmodics (like Detrol®), opiates (like Vicodin®) and tricyclic antidepressants (like Elavil®) can change the way the bladder muscle works.
Moreover, low magnesium concentrations can lead to bladder spasm and urinary frequency. High extracellular magnesium concentrations reduced the magnitude of the electrically-induced phasic contractions, as well as spontaneous contractions of the human detrusor smooth muscle in vitro.