SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re‑infestation, it is important to treat all dogs and cats within a household with a flea control product.
The appropriate strength tablet(s) should be used according to the dog's weight. For treatment of tick and flea infestations Simparica should be given once every month throughout the flea and/or tick season for optimal control. For treatment of sarcoptic mange, Simparica is given monthly for two consecutive months.
Simparica TRIO should be administered at monthly intervals. It can be given year-round or, at minimum, within one month of the dog's first seasonal exposure to mosquitoes and continued until at least one (1) month after the dog's last seasonal exposure to mosquitoes.
SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). SIMPARICA TRIO can be offered to the dog with or without food.
For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks. Further flea or tick treatment should be continued using a different veterinary medicine with a narrower range of action.
If you forget a month of preventative, make sure to give the next 2 doses on time to "catch up" for that missed month. If you miss several months in a row, you should give your vet a call for advice on when to plan for the next heartworm test and how to get started back on preventatives.
As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
This small, chewable tablet kills fleas and ticks for up to 35 days to help prevent illnesses in your dog and eliminate and prevent home infestations.
You can give it at any time of the day and you can give it with or without food. After you give your dog his Simparica chew the ingredient sarolaner travels in your dog's blood and quickly reaches tissue fluids just under your dog's skin.
Simparica kills adult fleas so fast they don't get a chance to lay eggs and reproduce. Why can I still see fleas on my dog after giving Simparica? Fleas can live in a variety of areas outside of your home as well as on other dogs that your dog may encounter.
If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. Contact your vet if your dog misses a month or more of heartworm prevention—your dog might have become infected with heartworm larvae.
If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.
The laboratory studies demonstrated that Simparica Trio™ is highly effective against the four tick species that commonly infest dogs in Europe within 48 hours of treatment of an existing infestation and within 48 hours of re-infestation for one month following treatment.
You give you pets a once-a-month flea treatment, but you see some fleas before those 30 days are up.
For those of us that don't always remember to give our preventatives on day 30, Simparica's effects will last until day 35 without tapering off, providing continuous protection. This allows owners a 5 day margin of error should they forget to give their preventatives on time.
Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders.
Facts about fleas. Monthly Simparica starts killing fleas fast* (before they can lay eggs), and it goes strong for 35 days. Simparica provides much-needed, fast relief for dogs with fleas and dogs with flea allergies.
Simparica Trio is a highly effective and convenient medication for preventing flea, tick, and heartworm infestations in dogs. It offers long-lasting protection and is generally safe for most dogs.
Moxidectin is readily and rapidly absorbed systemically following oral dosing, reaching maximum concentrations in plasma within 2.4 hours (tmax) after administration and with 66.9% bioavailability.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
Number of Tablets Administered
SIMPARICA should be administered at monthly intervals. Flea Treatment and Prevention: Treatment with SIMPARICA may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with SIMPARICA can continue the entire year without interruption.
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
Results: Simparica Trio was generally well tolerated. Emesis occurred at low frequency in all groups including control. Abnormal stool occurred occasionally in the 1× and 3× groups throughout the 3-month study.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.