Passive transfer of Sjogren's syndrome IgG produces the pathophysiology of overactive bladder. Arthritis Rheum.
Vaginal dryness. Problems urinating, including pain, urinating more than usual, getting up at night often to urinate and needing to urinate suddenly.
If you have Sjogren's syndrome, you are also more likely to have a condition called painful bladder syndrome, or interstitial cystitis. This condition causes signs and symptoms similar to those of a urinary tract infection — urinary frequency, urgency and pain — without evidence of infection.
Interstitial cystitis (IC) is an autoimmune related condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. It is far more common in women than in men. The symptoms vary from person to person. Some people may have pain without urgency or frequency.
Incontinence can happen for many reasons, including urinary tract infections, vaginal infection or irritation, or constipation. Some medications can cause bladder control problems that last a short time. When incontinence lasts longer, it may be due to: Weak bladder or pelvic floor muscles.
Involuntary bladder contractions
Several conditions may contribute to signs and symptoms of overactive bladder, including: Neurological disorders, such as stroke and multiple sclerosis. Diabetes. Urinary tract infections that can cause symptoms similar to those of an overactive bladder.
Avoid foods that dry your mouth
You should also avoid spices and acidic foods such as citrus, as these can irritate a dry, sore mouth. You should also avoid sugary foods that can contribute to rapid tooth decay, which is already increased by lower saliva production in Sjogren's syndrome.
The disorder can affect the nervous system, muscles, joints, kidneys, lungs, blood vessels, liver, and pancreas. Sjögren's syndrome is a long-lasting disorder that affects females more often than men.
Sjogren's syndrome is a chronic autoimmune disorder in which the body's own immune system attacks the glands that produce tears and saliva. Foods that help are omega-3 fatty acids, organic meat, whole fruits and vegetables. Bad foods include trans fat, high glycemic, red meat, dairy, and artificial sweeteners.
In most people with Sjögren syndrome, dry eyes and dry mouth are the primary features of the disorder, and general health and life expectancy are largely unaffected.
Symptoms can be mild, moderate or severe, and the progression is often unpredictable. Women are most commonly affected by Sjogren's syndrome. There is no cure, but it can be managed effectively. In rare cases, organs such as the liver and kidneys may be involved, which can increase the severity of the condition.
Hydroxychloroquine (Plaquenil), a drug designed to treat malaria, is often helpful in treating Sjogren's syndrome. Drugs that suppress the immune system, such as methotrexate (Trexall), also might be prescribed.
Global cognitive impairment in Sjögren's
Most patients experience “brain fog” symptoms, which manifest as memory lapses, forgetfulness, mental confusion, and difficulties in concentrating, organizing, or anticipating future events.
These and previous studies suggest a model for pSS that separates the disease into several stages: 1) initial injury to the submandibular and lacrimal glands via an environmental insult and LTα; 2) amplification of local injury via the production of type 1 IFN; injury to the parotid glands, lungs, and kidneys is seen; ...
Sjögren's syndrome can also cause swollen or painful joints, muscle pain or weakness, dry skin, rashes, brain fog (poor concentration or memory), numbness and tingling sensations in the arms and legs due to nerve involvement, heartburn, kidney problems and swollen lymph nodes.
Specific Tests for Sjögren's Syndrome
Your doctor may recommend some or all of the following tests: Blood and urine tests, to look for the presence of antibodies common in Sjögren's syndrome. The results of an ANA (antinuclear antibody) test will determine if you have an autoimmune disorder.
Studies indicate that Sjogren's patients experience more physical fatigue than mental fatigue. These patients also report intense daytime sleepiness, an indicator of physical exhaustion. Some who suffer may experience severe symptoms, while others have mild symptoms.
Avoid medicines that are known to cause dry eyes. These include antihistamines, diuretics, and some antidepressants. Talk with your doctor if you take any of these medicines. Sometimes the benefits of a medicine outweigh the risks.
Falk: What kinds of factors can make Sjogren's worse? What is the effect, for example, of stress? Jonas: Well, like all autoimmune diseases, patients who feel stressed or are under unusual stress will often have exacerbation of their symptoms. Learning to manage that stress in your life is very important.
Causes of urinary incontinence
Stress incontinence is usually the result of the weakening of or damage to the muscles used to prevent urination, such as the pelvic floor muscles and the urethral sphincter. Urge incontinence is usually the result of overactivity of the detrusor muscles, which control the bladder.
Urge incontinence.
You have a sudden, intense urge to urinate followed by an involuntary loss of urine. You may need to urinate often, including throughout the night. Urge incontinence may be caused by a minor condition, such as infection, or a more severe condition such as a neurological disorder or diabetes.
Urge Incontinence is the inability to hold urine long enough to reach the bathroom. This sudden, uncontrollable urge to urinate is often found in people with other conditions, such as diabetes, stroke, dementia, Parkinson's disease and multiple sclerosis.