But beyond blood levels of 21 nanograms per milliliter of 25-Hydroxyvitamin D — considered the low end of the normal range for vitamin D — any additional increase in vitamin D was associated with an increase in CRP, a factor linked to stiffening of the blood vessels and an increased risk of cardiovascular problems.
Vitamin D deficiency has been associated with increased arterial calcification across a number of studies (57–60), and with the development of coronary artery calcification (61).
Vitamin D also affects blood extravasation at ruptured atherosclerotic plaque, which is a key element of acute coronary syndrome [17].
High doses of vitamin D can raise blood levels of calcium (hypercalcemia), which can damage the heart, kidneys, and blood vessels.
The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.
Some side effects of taking too much vitamin D include weakness, dry mouth, nausea, vomiting, and others. Taking vitamin D for long periods of time in doses higher than 4000 IU (100 mcg) daily is possibly unsafe and may cause very high levels of calcium in the blood.
But how do you flush vitamin D out of your system – and can you even do that? Yes, by ensuring you consume plenty of water. This will encourage urination, allowing your body to shed the excess vitamin D and calcium more quickly. Prescription diuretics like furosemide can also be helpful.
Kunutsor et al suggested that supplementation with vitamin D significantly reduced diastolic blood pressure (DBP) by 1.31 mm Hg in participants with preexisting cardiometabolic conditions (16).
There is no simple answer as to the amount of time it takes vitamin D to leave the body. However, with the knowledge that calcidiol provides the best indication of vitamin D levels, it can be asserted that in a time period of 15 days, your body will deplete half of its supply of serum vitamin D.
Optimal Vitamin K2 intake is crucial to avoid the calcium plaque buildup of atherosclerosis, thus keeping the risk and rate of calcification as low as possible.
Vitamin D and cholesterol: What to know. The connection, if any, between vitamin D and cholesterol is unclear. Some research suggests that vitamin D supplements may improve cholesterol levels. However, others indicate that vitamin D has no effect on low-density lipoprotein (LDL) cholesterol.
Yes, getting too much vitamin D can be harmful. Very high levels of vitamin D in your blood (greater than 375 nmol/L or 150 ng/mL) can cause nausea, vomiting, muscle weakness, confusion, pain, loss of appetite, dehydration, excessive urination and thirst, and kidney stones.
The high levels of calcium in your blood caused by vitamin D-3 can begin to form deposits in the walls of your heart and the lining of your blood vessels -- a process called calcification. Calcium deposits in your arteries put you at increased risk of heart disease, according to the Harvard School of Public Health.
If you've been prescribed high-dose vitamin D, work closely with your doctor to monitor your blood levels. It can take three months or more to bring them back up, but once they're good, you can stop the high doses and return to a lower vitamin D supplement for maintenance.
Safety and side effects
However, taking too much vitamin D in the form of supplements can be harmful. Children age 9 years and older, adults, and pregnant and breastfeeding women who take more than 4,000 IU a day of vitamin D might experience: Nausea and vomiting. Poor appetite and weight loss.
Extremely high vitamin D levels are harmful and can cause nausea, vomiting, confusion, excessive thirst and kidney stones. Vitamin D supplements can interact with certain medications, so check with your doctor before starting one.
vitamin D is an emerging risk factor of AF, and is implicated in the pathophysiology of atrial fibrillation. It has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system.
Growing evidence has demonstrated that vitamin D has a role in sleep regulation [12]. Specifically, vitamin D deficiency (VDD) can increase risk of sleep disorders and is associated with sleep difficulties, shorter sleep duration, and nocturnal awakenings in children and adults [13,14,15].
Though there have been many studies done on vitamin D and cholesterol, there's not enough evidence to say for certain if vitamin D helps lower cholesterol. A 2012 study published in Arteriosclerosis, Thrombosis, and Vascular Biology found that supplementing with vitamin D did nothing to lower participants' cholesterol.
The administration of doses higher than 100,000 IU of vitamin D is considered a megadose.
Taking too many vitamin D supplements over a long period of time can cause too much calcium to build up in the body (hypercalcaemia). This can weaken the bones and damage the kidneys and the heart. If you choose to take vitamin D supplements, 10 micrograms a day will be enough for most people.
What's more, taking too much vitamin D can also negatively impact our health as well as our joint pain because our body simply can't cope! If toxic levels of vitamin D build up in the body it can interfere with your body's absorption of calcium.