Studies have demonstrated that immune-activation may be a risk factor for ASD. A lack of vitamin D may alter the immune responses of patients with ASD, and vitamin D may prevent ASD-related behavior dilemmas induced by immune activation (Nakamura et al., 2010).
Theoretically, vitamin D can affect neurodevelopment in children with ASD through its anti-inflammatory properties, stimulating the production of neurotrophins, decreasing the risk of seizures, and regulating glutathione and serotonin levels.
The present study revealed that Vitamin D deficiency was higher in autism children compared to healthy children.
Maternal VD deficiency has been associated with an increased risk of ASD development in infants.
It's not clear precisely how prenatal vitamins might influence autism risk. It's also unclear which nutrient in the supplements is most beneficial. Some studies have linked a lack of folic acid, iron or vitamin D to autism.
A study published in the Journal of Child Psychology and Psychiatry and Allied Disciplines found that children with ASD who supplemented with Vitamin D3 showed improvement in signs and symptoms related to ASD.
Autism is not caused by malnutrition or food-related challenges, but, for many people, there is a connection between autism and food. Research suggests that food-related challenges have a significant impact on many people who are diagnosed on the autism spectrum.
Associations between biomarkers and ASD
Higher early pregnancy total folate levels were associated with an increased probability of having a child with ASD (OR per 1 SD increase: 1.70, 95% CI 1.22–2.37, P = 0.002).
The Boston Medical Center cohort study of 1257 mother-child pairs found that moderate self-reported maternal prenatal multivitamin use was protective against ASD, but both low (≤2 times per week) and high (>5 times per week) supplement use was associated with an increased risk of ASD.
Does The Father Or Mother Carry The Autism Gene? Autism was always thought to have a maternal inheritance component, however, research suggests that the rarer variants associated with the disorder are usually inherited from the father.
There are many different factors that have been identified that may make a child more likely to have ASD, including environmental, biologic, and genetic factors.
Advances in diagnostic capabilities and greater understanding and awareness of autism spectrum disorder seem to be largely driving the increase, the Rutgers researchers said. But there's probably more to the story: Genetic factors, and perhaps some environmental ones, too, might also be contributing to the trend.
As all studies show that autistic children are low in vitamin D, getting a 25-hydroxyvitamin D blood test to start is usually unnecessary. The first step is simply to give your child 50 IU of vitamin D3 per pound of body weight per day. Liquid vitamin D is available from several sources.
In terms of prevention, a recent small study showed vitamin D supplementation during pregnancy (5000 IU/day) and during infancy and early childhood (1000 IU/day) significantly reduced the expected incidence of autism in mothers who already had one autistic child from 20% to 5%.
– Children with autism may well need higher doses of vitamin B6 than healthy typical peers, for many reasons: Picky diets that lack vitamins, gut inflammation that impedes absorption of B vitamins, or gut microbial infections that eat up B vitamins before your child can absorb them.
High levels of stress during pregnancy may also be connected to autism in children. This connection appears to have the most impact when the parent experiences stress between weeks 25 and 28 of pregnancy.
The signs and symptoms of pediatric B 12 deficiency frequently mimic those of autism spectrum disorders. Both autistic and brain-injured B 12- deficient children have obsessive-compulsive behaviors and difficulty with speech, language, writing, and comprehension. B 12 deficiency can also cause aloofness and withdrawal.
Two such factors that have been associated with a significant proportion of ASD risk are prenatal stress exposure and maternal immune dysregulation. Maternal stress susceptibility appears to interact with prenatal stress exposure to affect offspring neurodevelopment.
The strongest direct evidence of foods linked to autism involves wheat and dairy, and the specific proteins they contain – namely, gluten and casein. These are difficult to digest and, especially if introduced too early in life, may result in an allergy.
If you or a loved one has ASD, paying close attention to the foods being consumed is particularly important. For our patients with autism, we often recommend an elimination diet—eliminating gluten, dairy, sugar, corn, soy, and other categories of potentially allergenic foods for one month.
Some more recommended food items that help autism symptoms include: Prebiotic-rich foods (apples, asparagus, leeks, garlic, onions, bananas, and chicory root)
Researchers found Vitamin B6 with Magnesium has the potential effects to alleviate the core symptoms of autism. A possible association higher doses of vitamin B6-Magnesium supplementation may reduce biochemical abnormalities e.g. reduction of urinary excretion of homovanillic acid and improve neurobehavioral symptoms.
We have previously shown that dietary zinc supplementation for 6 weeks post-weaning can prevent ASD-associated behavioural deficits and adjust the structure and function of glutamatergic cortico-striatal synapses in Shank3 deficient mice [45].
Research has shown that Methyl B12, also known as methylcobalamin, can help relieve symptoms of autism. In the body, B12 assists with detoxification because it is a critical factor of the methylation pathway that helps the body make the powerful antioxidant, glutathione.