For those on antidepressants but still depressed, many will also experience highly unpleasant side effects from the medications. Side effects can include weight gain, fatigue, sexual dysfunction, changes in personality, nausea, insomnia, and constipation.
When first starting antidepressants, you may suddenly find that you don't feel like yourself anymore. Though your depression symptoms may have improved, the overwhelming waves of gloom can sometimes be replaced by an emotional inertness in which are neither able to cry nor share a real belly laugh.
When you're benefiting from antidepressants, you should feel: A mood that is less depressed, less irritable, happier, and more content. Excitement for and pleasure in everyday activities and events. An ability to regulate your eating patterns without eating too much or too little.
Most antidepressants boost mood and reduce depression symptoms by elevating serotonin levels in the brain. Although this is beneficial for someone who's depressed, for someone who does not have depression, taking antidepressant medication can cause serotonin to build up in the body, resulting in serotonin syndrome.
Nearly half of patients on all types of monoaminergic antidepressants report emotional blunting,6 and it is associated with serotonin reuptake inhibitor (SSRI) therapy as follows: among 161 patients, 46% reported a narrowed range of affect, 21% reported an inability to cry, and 19% reported apathy.
In terms of how they make a person feel, antidepressants may have a number of positive effects. “The person taking the antidepressant has increased energy and is calmer,” Dr. McGee says. “They have improved motivation and their sleep and appetite are better regulated.
For most people, antidepressants are the main cause of emotional blunting. In most cases, feelings of numbness go away when you stop taking the antidepressant that is causing you to feel this way.
SSRIs and SNRIs
Common side effects of selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs) can include: feeling agitated, shaky or anxious. feeling and being sick.
In time, the brain readjusts and people should experience a return to their normal state. If depressive symptoms do arise and gradually worsen, it's best to consult a psychiatrist or doctor, if they don't improve within a few weeks or if they become severe.
One of the widely-reported side effects of SSRIs is 'blunting', where patients report feeling emotionally dull and no longer finding things as pleasurable as they used to. Between 40-60% of patients taking SSRIs are believed to experience this side effect.
It's usually recommended that a course of antidepressants continues for at least 6 months after you feel better, to prevent your condition recurring when you stop. Some people with recurrent illness are advised to carry on taking medicine indefinitely.
Generally, people see improvement after taking their antidepressants for three months. If you've been on antidepressants for three months and don't see any improvements in your symptoms or mood, then it's possible your antidepressant dose is too low.
Antidepressants may take a while to kick in. You may feel some depression symptoms improve within the first couple weeks, but it can often take 4 to 8 weeks to feel the full effects of your medication. If you've taken your antidepressant for at least 4 weeks with no improvement, let your healthcare provider know.
SSRIs are usually the first choice medicine for depression because they generally have fewer side effects than most other types of antidepressant.
There's a paradoxical period when a person first starts an antidepressant: they may actually begin to feel worse before feeling better. The underlying cause of this phenomenon is a bit of a mystery, but a new study from researchers at Otto-von-Guericke University in Germany explains why this might occur.
In the case of SSRIs, SNRIs, and related medications, the effects of taking antidepressants when not depressed can include developing a condition known as serotonin syndrome. Symptoms of this condition include the following: Confusion. Agitation.
Psychotherapy boosts the placebo effect and is "significantly more effective than medication" for all levels of depression, he says. Antidepressants should only be used "as a last resort and only for the most severely depressed".
Safety of daily doses above 20 mg has not been demonstrated. Usual dosage is 10 mg once daily. Depending on individual patient response, the dose may be increased to a maximum of 20 mg daily. Usually 2-4 weeks are necessary to obtain antidepressant response.
Generally speaking, SSRIs and SNRIs are well-tolerated by most people. They also have good evidence supporting their long-term safety. Older antidepressants, like TCAs and MAOIs, tend to cause more side effects.
During long-term SSRI therapy, the most troubling adverse effects are sexual dysfunction, weight gain, and sleep disturbance.
As the name denotes, SSRIs target serotonin, the chemical in the brain commonly dubbed the "happy" hormone. One of the common side effects of this type of antidepressant is a numb feeling. The patient may not feel pleasure as much as before, just like they won't feel as depressed.