Vitamin D supplement may have moderate or no effect on the dosage requirement or side effects of pravastatin, rosuvastatin and pitavastatin. Since vitamin D has mild HMG-CoA reductase activity, it will work synergistically with all statins.
The conclusion of the study is that vitamin D supplementation lowers atorvastatin and active metabolite concentrations yet has synergistic effects on cholesterol concentrations.
Each statin may affect vitamin D concentrations differently. Smaller, short-term studies have shown that more lipophilic statins (simvastatin and lovastatin) can cause increases in various metabolites of vitamin D, while less lipophilic statins (pravastatin) provide no improvement in vitamin D [26], [27], [28].
No interactions were found between atorvastatin and Vitamin D3.
Vitamin D levels and statin effectiveness
In one additional study,9 supplemental vitamin D (800 IU/day) enhanced the effect of atorvastatin therapy on total and LDL cholesterol (P < 0.005).
Try taking it alongside breakfast or with a bedtime snack — as long as it doesn't interfere with your sleep. The key is to find what works for you and stick with it to ensure you're meeting your vitamin D needs. Taking vitamin D with a meal can increase its absorption, but studies on specific timing are limited.
Coenzyme Q10 (CoQ10), a nutrient produced by the body and used for cellular energy, is often touted as being vital if you're taking statin drugs to lower cholesterol. Proponents of CoQ10 say it helps reduce muscle pain, which can be a side effect of statin use, and is an important energy source that the body needs.
Digoxin (Lanoxin).
Avoid taking high doses of vitamin D with this heart medication. High doses of vitamin D can cause hypercalcemia, which increases the risk of fatal heart problems with digoxin.
One 2012 study found that vitamin D supplements have no cholesterol-lowering effects, at least in the short term. In fact, the researchers found that the supplements were actually associated with an increase in LDL.
This is a general list of medications that you should be aware of: Antacids containing magnesium or aluminum hydroxide may decrease the concentration of some statins in the body. This may be prevented by taking your statin dose and antacid dose at least two hours apart.
Results. We have found a significant association between deficient and insufficient vitamin D status and statin-associated muscle symptoms (SAMS). Vitamin D deficiency (<30 nmol/L) presents 77% (95% C.I. 71.6% to 81.7%) sensitivity and 63.4% (95% C.I.
Too much vitamin D can cause calcium to accumulate in your blood, which can damage your heart, blood vessels, and kidneys.
There are quite a few differences between vitamin D and vitamin D3, but the main difference between them is that vitamin D is a fat-soluble vitamin that regulates calcium and phosphorous levels in the body, whereas the vitamin D3 is the natural form of vitamin D produced by the body from sunlight.
Results of the study confirm that Vitamin D supplementation has a role in reducing blood pressure in hypertensive patients and that it should be supplemented with the antihypertensive drugs.
Some people may be able to take fish oil alongside statins. However, EPA and DHA have different effects on LDL. Some studies suggest that combining statins with DHA may increase LDL, which can be a problem for people who are taking statins to lower their LDL levels. EPA has no effect or a slight lowering effect on LDL.
Supplements that should be avoided include red yeast rice, garlic, sustained-release niacin, no flush niacin, and niacinamide. These supplements have no data to support their use in lowering cholesterol levels or have been associated with liver damage. Remember, if you have Questions, Consult Your Pharmacist.
Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
Is there a benefit to taking vitamin D at night? There's been some buzz suggesting a link between supplementing with vitamin D before bedtime and the ability to drift off to dreamland. Some studies have shown that vitamin D is connected to the production of melatonin, which regulates circadian rhythm and drives sleep.
Research suggests vitamin D is involved in your body's production of melatonin, a hormone that helps regulate your circadian rhythms and can benefit your overall sleep quality. This means vitamin D might actually improve your sleep quality.
Mayo Clinic recommends that adults get at least the RDA of 600 IU. However, 1,000 to 2,000 IU per day of vitamin D from a supplement is generally safe, should help people achieve an adequate blood level of vitamin D, and may have additional health benefits.
Interactions between your drugs
No interactions were found between Crestor and Vitamin D3.