Doflamingo is strong enough to beat most pirates, but he was defeated by Monkey D. Luffy, and there are several other pirates who can beat him as well.
The battle finally ends after a duration of eight episodes.
Luffy stops Doflamingo, and the two clash using Haoshoku Haki. During the battle, Trebol remembers how he found a young Doflamingo and gave him the power to kill anyone he wanted. Doflamingo uses his powers to heal himself and attack Law. Luffy stops Doflamingo, and the two clash using Haoshoku Haki.
Gear Fourth debuted during the Dressrosa arc of One Piece, in chapter 784 of the manga and episode 726 of the anime. This form was used by Luffy to finally defeat Doflamingo and free Dressrosa from his control.
Kaido is one of the best fights that fans have seen in One Piece over the years, if not the best. The fight is, undoubtedly, the most difficult one that Luffy has fought so far. Kaido managed to defeat Luffy three times. For the first time, Luffy faced defeat against him Kuri and was thrown in prison.
1. Kaidou. With his immense physical strength and supernatural abilities, Kaidou is one of the most potent villains Luffy ever faced. Kaidou is also known as the "Strongest Creature," and he's one of the Four Emperors ruling the New World.
Zoro could also take anything doflamingo could dish out. Since he not only took a combined attack from big mom and kaido but also afterwards took multiple attacks from king.So I conclude Zoro wins mid difficulty.
Weaknesses. Despite these advantages Luffy is not immortal. Though immune to lightning, he can be damaged by other elements such as fire or ice, attacks involving cutting or stabbing and Haki-infused attacks.
After the time skip, Luffy grows more powerful and receives a bounty of 500,000,000 Berries, after defeating a third Warlord, Donquixote Doflamingo.
Shortest fight: 4 chapters; Longest fight: 33 chapters; Average: 10.6 12.2 chapters. In terms of actual fights, "Luffy vs. Commander Dogtooths" has more fighting scenes than "Luffy vs. God-Eneru" -"Luffy vs.
Luffy fought several enemies. Yes, he triumphed many times, but at other times, he suffered humiliating defeats. Here are 5 Times Luffy emerged victoriously, and 5 times he suffered a bitter defeat.
1 WON'T SURPASS: DONQUIXOTE DOFLAMINGO
It is pretty obvious that when Doflamingo could not stand up to the power of Gear 4th Luffy, there's no chance of him surpassing someone like Garp in terms of strength.
5 Can't Defeat: Doflamingo
These strings are known to be very durable and can cut through almost anything. Thanks to his Devil Fruit, he has become a strong pirate, without a doubt, however, he can't defeat a Yonko.
During the Dressrosa Arc, Sanji tried to fight against Doflamingo, but he didn't stand a chance. After just a few exchange of blows, the Warlord easily defeated him and was about to take his life.
4 Monkey D. Luffy
In the Wano Country arc, Luffy faced the toughest challenge yet as he went up against Kaido, who held the title of the "Strongest Creature in the World."
Buggy is the captain of the Buggy Pirates and one of the Four Emperors of the Sea. A person who has not met Buggy can easily be fooled by his titles, but those who have know that he is one of the weakest characters in the series.
Nami fought Ulti in the Wano Country arc and the two clashed on a few occasions. Although Nami successfully landed a couple of blows on her, it wasn't until she got her hand on Zeus that she finally defeated her.
Luffy falls off Onigashima defeated.
Mihawk, without a doubt. He is called the strongest swordsman for a reason.
Conis and the rest of Skypiea witnessed Luffy completely destabilize Enel's attack. She then witnessed Luffy finally defeat Enel by punching the god straight into the golden bell.
Luffy's greatest power-up to date is, undoubtedly, Conqueror's Haki coating. During his fight against Kaido, Luffy observed Kaido coating his weapon in Conqueror's Haki. After this realization hit him, he was able to use a crude version of this technique himself and could coat his fists in Conqueror's Haki.
Dracule Mihawk is Zoro's biggest rival, being the man who holds the title of the World's Strongest Swordsman. Mihawk is extremely skilled with the blade and his swordplay is described as very aesthetic. He is also extremely good at using Haki given that he taught its usage to Zoro.