Conclusion: Statins lower blood pressure by cholesterol-independent mechanisms, and the reduction is larger in individuals with higher blood pressure and those with low HDL-C.
Statins are the most widely prescribed and effective medication for reducing low density lipoprotein cholesterol. Statins may also lower resting blood pressure (BP); however, results are inconsistent.
Systolic blood pressure was significantly lower in patients on statin than in those on placebo or control hypolipidemic drug (mean difference: −1.9 mm Hg; 95% CI: −3.8 to −0.1).
Statins block an enzyme the liver needs to make cholesterol. This causes the liver to remove cholesterol from the blood. While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people. Rarely, they may cause liver damage.
Statins can stabilize cholesterol plaque already attached to artery walls, making it less likely to get worse or rupture, causing a heart attack or stroke. "Statins also help remove cholesterol from you blood by causing the liver to express more LDL cholesterol receptors that take cholesterol out of your blood," Dr.
Statin use has been linked to a higher risk of developing diabetes because the medication can fuel mild glucose elevations in predisposed individuals — an effect that can often be countervailed by exercise and losing as little as a few pounds.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so.
feeling sick. feeling unusually tired or physically weak. digestive system problems, such as constipation, diarrhoea, indigestion or farting. muscle pain.
Statins should be taken with caution if you're at an increased risk of developing a rare side effect called myopathy, which is where the tissues of your muscles become damaged and painful. Severe myopathy (rhabdomyolysis) can lead to kidney damage. Things that can increase this risk include: being over 70 years old.
Grapefruit juice can affect some statins and increase your risk of side effects. Your doctor may advise you to avoid it or to only consume it in small quantities. There are no known interactions between statins and alcohol.
Our study reported that both 5 mg and 10 mg rosuvastatin significantly decreases blood cholesterol, triglycerides, and LDL levels.
Taking daily doses of two blood pressure drugs (fixed dose candesartan and hydrochlorothiazide) along with a cholesterol-lowering drug (low-dose rosuvastatin), proved to be the most effective, cutting first-time strokes by 44 percent among patients at intermediate risk for heart disease.
The usual dose for adults is between 10mg and 80mg a day. Your dose depends on the reason why you're taking it, your cholesterol levels, and what other medicines you're taking.
In experimental studies, statins have been shown to lower blood pressure through increased nitric oxide bioavailability and improved arterial compliance. The clinical significance of this effect remains poorly documented.
Since statins can cause muscle damage, they could theoretically also harm the heart--which is, essentially, a big muscle--although there is no evidence that this is the case.
Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.
Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake.
Although there are some potential side effects long-term for statins, in most cases, if your doctor has identified you as having high cholesterol and needing a statin, the benefits greatly outweigh the risks. Muscle aches are among the most common complaints.
Statins are effective, accessible, and affordable. However, well-known side effects like muscle pain keep some people from taking them.
Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
There's no debate that individuals with LDL levels above 190 should be on a cholesterol-lowering medicine, but according to a 2022 study, less than half of such individuals in their 20s and 30s are prescribed a statin.
Ezetimibe. Ezetimibe is a tablet that lowers cholesterol. It may be prescribed if statins cannot be taken, or alongside a statin for extra cholesterol-lowering.
If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.