That's why many HCPs and researchers have started to support the use of Vitamin B12 for depression and antidepressant withdrawals. In fact, many studies show that Vitamin B12 could be one of the major factors contributing to depression in the first place.
B12 acts as a cofactor in synthesis of neurotransmitters such as serotonin and dopamine, thus B12 deficiency affects mood, emotions and sleeping and can lead to psychiatric disorders.
B12 deficiency and low normal B12 levels are common and may be associated with depression and the inadequate response to antidepressant treatment in patients with depression. Vitamin B12 supplementation with antidepressants has significantly improved depressive symptoms in our group.
Vitamin B12 is considered an important brain and nervous system micronutrient and is often used for anxiety. It helps to ensure normal function for your nerves, which can help combat physical symptoms of anxiety.
Vitamin B-12 and other B vitamins play a role in producing brain chemicals that affect mood and other brain functions. Low levels of B-12 and other B vitamins such as vitamin B-6 and folate may be linked to depression.
Once you begin treating your vitamin B12 deficiency, it can take up to six to 12 months to fully recover. It is also common to not experience any improvement during the first few months of treatment. If you can, it's a good idea to address what's causing the deficiency.
Very high daily doses of vitamin B12, ranging between 1000 and 2000 mcg, may effectively restore B12 levels within the body and positively impact depression symptoms. Even doses as low as 100 mcg are potent enough to positively impact cognition in adults with depressive symptoms.
Vitamin B12 deficiency can have distressing neuropsychiatric symptoms. It can have an etiological role in clinical presentations like depression, anxiety, psychosis, dementia, and delirium, requiring screening of at-risk populations.
Effects of Vitamin B12 on Depressive Symptoms
Higher intakes of both Vitamins B12 and B6 reduced depressive symptoms over time. Vitamin B12 levels were reported to be correlated with melancholic depressive symptoms more than non-melancholic.
Ask your doctor about the risks of taking St. John's wort, garcinia cambogia, L-tryptophan (or 5-HTP) and SAMe (S-adenosyl-methionine) supplements with your antidepressant. Consumer Labs says they can increase your risk of experiencing serotonin syndrome.
A lack of B12 can mess with your mental health and eventually can lead to depression or anxiety. One theory why: Low B12 may affect the production of mood-regulating neurotransmitters like serotonin and dopamine, the same brain chemicals impacted in depression that's not related to B12.
Several different B vitamins (including B6, B9, and B12) are believed to be essential for serotonin production and release.
To avoid brain fog from vitamin B12 deficiency, doctors recommend that adults get around 2.4 micrograms per day.
Vitamin B-3 and Vitamin B-9 can help people with depression because B vitamins help the brain manage moods. Vitamin D, melatonin and St. John's Wort are recommended for seasonal depression. Omega-3 fatty acids, magnesium and vitamin C may also help with depression.
Some studies have found promising effects of magnesium supplementation in the treatment of depression. A 2017 study found that magnesium supplements improved symptoms of depression in adults. This study included 112 individuals who were diagnosed with depression and had current mild-to-moderate symptoms.
Folic acid and vitamin B12 are involved in the synthesis of serotonin and other neurotransmitters. Vitamin B12 deficiency has been found in many patients who have depression or decreased attention, concentration, and memory.
Thus if you're otherwise healthy but still continue to feel tired after taking a B-12 supplement, it could be a sign of a mild allergic reaction. If a rash, difficulty breathing or swelling coincides with taking your dose of B-12, get to the doctor right away.
B12 supplements are usually safe. For adults, doctors recommend 2.4 micrograms a day. If you take more than what you need, your body passes the rest out through your pee. Still, high doses could have some side effects, like dizziness, headache, anxiety, nausea, and vomiting.
When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, higher doses have been found to be safe. Your body absorbs only as much as it needs, and any excess passes through your urine.