Afterwards researchers tested how well blood flowed through the arteries of people in the study. The results were encouraging. The CoQ10 supplement improved blood vessel health by about 42%, so the researchers thought this meant that the risk of heart disease was lowered by 13%.
Several clinical studies involving small numbers of people suggest that CoQ10 may lower blood pressure. However, it may take 4 to 12 weeks to see any change.
Recent research links low blood levels of CoQ10 with low levels of heart-protective “good” cholesterol which in turn may further increase risk for heart disease. Cholesterol-lowering statins may also reduce blood levels of CoQ10.
CoQ10 has been shown to improve symptoms of congestive heart failure. Although findings are mixed, CoQ10 might help reduce blood pressure. Some research also suggests that when combined with other nutrients, CoQ10 might aid recovery in people who've had bypass and heart valve surgeries.
A 12-week study in 50 people with diabetes found that those who received 100 mg of CoQ10 per day had significant reductions in blood sugar, markers of oxidative stress and insulin resistance, compared to the control group ( 27 ). Doses of 100–300 mg of CoQ10 per day appear to improve diabetes symptoms ( 28 ).
If you eat sources of saturated fat, like beef, switching to foods with omega-3 fatty acids, like fatty fish, can help lower your heart disease risk. CoQ10 may offer benefits if you already struggle with cardiovascular disease risk or you've had a heart attack.
In some cases, doses may be gradually increased to 3000 mg per day. For heart failure and fluid build up in the body (congestive heart failure or CHF): 30 mg once daily, or up to 300 mg per day divided into two or three doses for up to 2 years. Also, 2 mg/kg daily for up to one year has been used.
Drug Interactions and Additive Effects
On the other hand, some studies have shown that CoQ10 has done the complete opposite to Vitamin K Antagonists and actually enhanced the anti-blood-clotting effect, which leads to excessive bleeding.
Risks. People with chronic diseases such as heart failure, liver problems, or diabetes should be wary of using this supplement. CoQ10 may lower blood sugar levels and blood pressure.
Answer: Studies with CoQ10 have not shown serious adverse effects at moderate doses even when taken for several years — although it may be best to divide the dose over the course of the day.
Safety. No serious side effects of CoQ10 have been reported. Mild side effects such as insomnia or digestive upsets may occur. CoQ10 may interact with the anticoagulant (blood thinner) warfarin and the diabetes drug insulin, and it may not be compatible with some types of cancer treatment.
Other neurological abnormalities that can occur in primary coenzyme Q10 deficiency include seizures, intellectual disability, poor muscle tone (hypotonia), involuntary muscle contractions (dystonia), progressive muscle stiffness (spasticity), abnormal eye movements (nystagmus), vision loss caused by degeneration ( ...
There's no standard guideline for the best time to take CoQ10. However, the general rec is to take CoQ10 in the morning with a meal, due to its potential energizing effects. * But like all supplements, CoQ10 isn't one-size-fits-all—so it's possible that a later-in-the-day dose might work for you.
CoQ10 supplementation is associated with increased energy levels. As with other supplements that boost energy levels, CoQ10 users have reported side effects such as slight stomach upset, headaches, feeling jittery or “wired,” and experiencing mild insomnia.
The findings showed that taking CoQ10 by patients with CAD significantly decreased total-cholesterol (SMD -1.07; 95% CI, − 1.94, − 0.21, P = 0.01) and increased HDL-cholesterol levels (SMD 1.30; 95% CI, 0.20, 2.41, P = 0.02).
CoQ10 has been shown to help improve heart health and blood sugar regulation, assist in the prevention and treatment of cancer and reduce the frequency of migraines. It could also reduce the oxidative damage that leads to muscle fatigue, skin damage and brain and lung diseases.
In addition to reducing the risk of cardiovascular problems in patients with liver disease, CoQ10 supplementation may also benefit the disease process within the liver by reducing inflammation and oxidative stress.
Coenzyme Q10 has no known severe, serious, or moderate interactions with other drugs.
Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease.
If you have a heart-related condition, CoQ10 may help due to its antioxidant properties. It may also improve energy production in cells and prevent blood clots.
Answer: CoQ10 can be taken at the same time as statin medication.
Many people take CoQ10 for hypertension, cardiovascular health, or both. A non‐Cochrane review concluded that CoQ10 reduced blood pressure (Rosenfeldt 2007).
Answer: Yes, it is possible that CoQ10 is making it harder for you to fall asleep. Fortunately, there are ways to minimize this effect. Learn more in the Concerns and Cautions section of the CoQ10 and Ubiquinol Supplements Review.
No interactions were found between CoQ10 and Omega 3-6-9 Complex. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Research indicates that supplementing with CoQ10 or magnesium may provide palpitation relief in some individuals. One study investigating the effects of CoQ10 on heart failure found that 50 mg/day for 4 weeks led to a reduction in heart palpitations in participants.