Hypomagnesemia associates with inflammation and risk of diabetes and hypertension, which may contribute to kidney function decline.
Magnesium supplements can cause excessive accumulation of magnesium in the blood, especially with patients who have chronic kidney disease. Accumulation of magnesium in the blood can cause muscle weakness, but does not damage the kidney directly.
Every organ in the body, especially the heart, muscles, and kidneys, needs the mineral magnesium. It also contributes to the makeup of teeth and bones.
The connection between magnesium and the kidney is manifold. More than being regulated by intestinal absorption, magnesium homeostasis is governed by reabsorption of magnesium from primary urine in the kidney. Of about 2,400 mg magnesium that is being ultra-filtrated daily, 95-99% must be reabsorbed by the nephrons.
Magnesium deficiency can cause a wide variety of features including hypocalcaemia, hypokalaemia and cardiac and neurological manifestations. Chronic low magnesium state has been associated with a number of chronic diseases including diabetes, hypertension, coronary heart disease, and osteoporosis.
The use of chemicals, such as fluoride and chlorine, bind to magnesium, making the water supply low in the mineral, as well. Common substances — such as sugar and caffeine — deplete the body's magnesium levels.
Magnesium status is closely linked with liver function. Liver diseases have a significant effect on body magnesium content, and magnesium levels in turn influence these disease processes.
Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease.
Magnesium supplementation can not only preserve liver function, but also slow the progression of liver disease, and reduce the mortality associated.
Chronic magnesium deficiency is often associated with normal serum magnesium despite deficiency in cells and in bone; the response to oral supplementation is slow and may take up to 40 weeks to reach a steady state.
High doses of some vitamins can be harmful, particularly for people with kidney diseases. For example, excessive intake of vitamin D supplements can lead to high levels of calcium in the blood, which can damage the kidneys.
People with diabetes, intestinal disease, heart disease or kidney disease should not take magnesium before speaking with their health care provider. Overdose. Signs of a magnesium overdose can include nausea, diarrhea, low blood pressure, muscle weakness, and fatigue. At very high doses, magnesium can be fatal.
Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.
The benefits of magnesium supplementation in healthy individuals aren't clear, but Dr. Nassar says that taking a magnesium supplement every day likely isn't unsafe for most people. Just be sure you're not taking too much magnesium. The maximum dietary allowance for most adults is around 400 mg or less.
Zinc is considered an essential trace element for humans, and zinc deficiency has been linked to adverse outcomes in kidney disease.
"The people at highest risk for low magnesium are those with diarrhea and other forms of malabsorption," like Crohn's disease and celiac disease, says Dr.
Antibiotics: Taking magnesium supplements may reduce the absorption of quinolone antibiotics, tetracycline antibiotics, and nitrofurantoin (Macrodandin). Magnesium should be taken 1 hour before or 2 hours after taking these medications. Quinolone and tetracycline antibiotics include: Ciprofloxacin (Cipro)
The body needs magnesium to maintain the health of muscles, including the heart. Research has found that magnesium plays an important role in heart health. A 2018 review reports that magnesium deficiency can increase a person's risk of cardiovascular problems. This is partly due to its roles on a cellular level.